{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:35:52Z","timestamp":1787240152368,"version":"build-2736575974"},"reference-count":27,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2015,10,26]]},"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CT angiography (CTA) is increasingly used for the detection, characterization, and follow-up of intracranial aneurysms. A lower threshold to request a CT angiogram may render a patient population that differs from previous studies primarily evaluated with conventional angiography. Our objective was to broaden our knowledge of the factors associated with aneurysm rupture and patient mortality in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All CTA studies performed over a 10-year period at a large neurovascular referral center were reviewed for the presence of an intracranial aneurysm. Patient demographics, mortality, CTA indication, aneurysm location, size, and rupture status were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>2927 patients with aneurysms were identified among 29\u2005003 CTAs. 17% of the aneurysms were ruptured at the time of imaging, 24% of aneurysms were incidentally identified, and multiple aneurysms were identified in 34% of patients. Aneurysms most commonly arose from the supraclinoid internal carotid artery (22%), the middle cerebral artery (18%), and the anterior communicating artery (13%). Male sex, age &lt;50\u2005years, aneurysms &gt;6\u2005mm, and aneurysms arising from the anterior communicating artery, posterior communicating artery, or the posterior circulation were independent predictors of aneurysm rupture. Independent mortality predictors included male sex, posterior circulation aneurysms, intraventricular hemorrhage, and intraparenchymal hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicate that aneurysms detected on CTA that arise from the anterior communicating artery, posterior communicating artery, or the posterior circulation, measure &gt;6\u2005mm in size, occur in men, and in patients aged &lt;50\u2005years are associated with rupture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/neurintsurg-2015-012082","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T23:08:37Z","timestamp":1447110517000},"page":"1168-1172","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Detection and characterization of intracranial aneurysms: a 10-year multidetector CT angiography experience in a large center"],"prefix":"10.1136","volume":"8","author":[{"given":"Jeremy J","family":"Heit","sequence":"first","affiliation":[{"name":"Interventional Neuroradiology Division, Department of Radiology, Stanford University Hospital, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Gilberto","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sabbag","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Bart","family":"Brouwers","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Radiology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar Gerardo","family":"Ordonez Rubiano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Infantil Universitario de San Jose, Bogota, Bogota, Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela W","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Neurointerventional Radiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier M","family":"Romero","sequence":"additional","affiliation":[{"name":"Neuroradiology Division, 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