{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:26:49Z","timestamp":1790965609391,"version":"4.1.0"},"reference-count":7,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2016,1,29]]},"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Brain capillary vascular malformations (CVMs) are known to occur with relatively high frequency in hereditary hemorrhagic telangiectasia (HHT) patients. These lesions are thought to have a benign natural history but this has not been systematically studied. The purpose of our study was to examine the natural history of CVMs in a consecutive series of HHT patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Consecutive patients with untreated CVMs receiving serial imaging were included. Baseline data including demographics, HHT gene mutations, and Curacao diagnostic criteria were collected. The primary outcome was rupture on follow-up. A secondary outcome was new focal neurological deficit or seizure related to the lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>22 patients with 42 CVMs were included. Mean age was 45.9\u00b116.9\u2005years. 18 patients (81.8%) were women and 4 (18.2%) were men. 19 patients (86.4%) had definite HHT and 3 patients (13.6%) had probable HHT. Mean follow-up was 4.6\u00b13.7\u2005years. There were a total of 100.2 patient years of follow-up and 222.5 lesion years. No lesions ruptured on follow-up and no patient had focal neurological deficits or seizures related to the lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study found that CVMs in HHT patients have a benign natural history as no patients had hemorrhage or other symptoms related to these lesions. These findings should be confirmed in additional multicenter longitudinal studies.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2015-012252","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T03:59:21Z","timestamp":1456545561000},"page":"26-28","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Natural history of brain capillary vascular malformations in hereditary hemorrhagic telangiectasia patients"],"prefix":"10.1136","volume":"9","author":[{"given":"Waleed","family":"Brinjikji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek N","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lanzino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent R","family":"Thielen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"2024052303054759000_9.1.26.1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4210"},{"key":"2024052303054759000_9.1.26.2","unstructured":"Yang W , Liu A , Hung A , et al . Lower risk of intracranial arteriovenous malformation hemorrhage in patients with hereditary hemorrhagic telangiectasia. Neurosurgery 2015. [Epub ahead of print]."},{"key":"2024052303054759000_9.1.26.3","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007367"},{"key":"2024052303054759000_9.1.26.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-006-6009-x"},{"key":"2024052303054759000_9.1.26.5","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.92.5.0779"},{"key":"2024052303054759000_9.1.26.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-005-1390-8"},{"key":"2024052303054759000_9.1.26.7","first-page":"1016","article-title":"Angiographic and clinical characteristics of patients with cerebral arteriovenous malformations associated with hereditary hemorrhagic telangiectasia","volume":"21","author":"Matsubara","year":"2000","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2015-012252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T11:26:27Z","timestamp":1716463587000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2015-012252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,26]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,14]]},"published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1136\/neurintsurg-2015-012252"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2015-012252","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,26]]}}}