{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:40:44Z","timestamp":1759178444524,"version":"3.44.0"},"reference-count":29,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2016,3,18]]},"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Time to reperfusion following endovascular treatment (ET) predicts outcomes after acute ischemic stroke (AIS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess the time\u2013outcome relationship within reperfusion grades in the North American Solitaire Acute Stroke registry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We identified patients given ET for anterior circulation ischemic stroke within 8\u2005h from onset and in whom reperfusion was achieved. Together with clinical and outcome data, site-adjudicated modified Thrombolysis in Cerebral Ischemia (TICI) was recorded. We assessed the impact of time to reperfusion (onset to procedure completion time) on good outcome (modified Rankin Scale 0\u20132 at 3\u2005months) in patients who achieved TICI 2 or higher reperfusion in multivariable models. We further assessed this relationship within strata of reperfusion grades. A p&lt;0.05 was considered significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Independent predictors of good outcome at 3\u2005months among those achieving TICI \u22652a reperfusion (n=188) were initial National Institutes of Health Stroke Scale score (adjusted OR=0.90, 95% CI 0.85 to 0.95), symptomatic hemorrhage (adj. OR=0.16, 95% CI 0.05 to 0.60), TICI grade (TICI 3: adj. OR=11.52, 95% CI 3.34 to 39.77; TICI 2b: adj. OR=5.14, 95% CI 1.61 to 16.39), and time to reperfusion per 30\u2005min interval (adj. OR=0.91, 95% CI 0.82 to 0.99). There was an interaction between final TICI grade and 30\u2005min time to reperfusion intervals (p=0.001) such that the effect of time was strongest in TICI 2a patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Time to reperfusion was a strong predictor of outcome following ET for AIS. However, the effect varied by TICI grade such that its greatest effect was in those achieving TICI 2a reperfusion.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2016-012288","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T23:13:09Z","timestamp":1460502789000},"page":"366-369","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Complete reperfusion mitigates influence of treatment time on outcomes after acute stroke"],"prefix":"10.1136","volume":"9","author":[{"given":"Shyam","family":"Prabhakaran","sequence":"first","affiliation":[{"name":"Northwestern University, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia C","family":"Castonguay","sequence":"additional","affiliation":[{"name":"University of Texas, MD Anderson, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Wellstar Neurosurgery Kennestone Hospital, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Huan J","family":"Sun","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coleman O","family":"Martin","sequence":"additional","affiliation":[{"name":"Saint Luke's Kansas City, Kansas City, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Holloway","sequence":"additional","affiliation":[{"name":"Saint Luke's Kansas City, Kansas City, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils H","family":"Mueller-Kronast","sequence":"additional","affiliation":[{"name":"Delray Medical Center, Delray Beach, Florida, 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Village, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hormozd","family":"Bozorgchami","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University, Portland, Oregon, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Xavier","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansaar","family":"Rai","sequence":"additional","affiliation":[{"name":"West Virginia University Hospital, Morgantown, West Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Froehler","sequence":"additional","affiliation":[{"name":"West Virginia University Hospital, Morgantown, West Virginia, USA"},{"name":"Vanderbilt University Medical Center, Nashville, Tennessee, 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