{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:07:24Z","timestamp":1783775244354,"version":"3.55.0"},"reference-count":28,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K20001"],"award-info":[{"award-number":["16K20001"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25861267"],"award-info":[{"award-number":["25861267"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2016,6,15]]},"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Increased platelet reactivity after carotid artery stenting (CAS) may cause thromboembolic complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aimed to investigate the incidence of increased platelet reactivity after CAS and to determine the factors related to it.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients who underwent CAS were recruited prospectively. They received pre-procedural antiplatelet therapy comprising some combination of aspirin (100\u2005mg\/day), clopidogrel (75\u2005mg\/day), and\/or cilostazol (200\u2005mg\/day) for a minimum of 7\u2005days. ADP- and collagen-induced platelet aggregation were measured before and 4\u2005days after CAS. Changes in platelet reactivity were reported as changes in the categorized platelet reactivity grade based on the effective dose 50%. Clinical characteristics of patients with and without increased platelet reactivity were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 38 consecutive patients who underwent CAS, 18 (47%) exhibited increased platelet reactivity. Diabetes mellitus (OR 15.0; 95% CI 2.1 to 106.5; p=0.007) and carotid artery plaques exhibiting high-intensity signals (HIS) on time-of-flight MR angiography (TOF-MRA) (OR 25.2; 95% CI 2.0 to 316.2; p=0.013) were independently associated with increased platelet reactivity in a multivariate analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Increased platelet reactivity occurred in nearly half of the studied patients subjected to CAS and was independently associated with diabetes mellitus and carotid artery plaques exhibiting HIS on TOF-MRA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2016-012419","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T23:24:39Z","timestamp":1467415479000},"page":"106-110","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Diabetes mellitus and carotid artery plaques exhibiting high-intensity signals on MR angiography are related to increased platelet reactivity after carotid artery stenting"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-8049","authenticated-orcid":false,"given":"Masanori","family":"Tsujimoto","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouji","family":"Kokuzawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Iwama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"2025092913062752000_9.1.106.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108153250701"},{"key":"2025092913062752000_9.1.106.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520420037035"},{"key":"2025092913062752000_9.1.106.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09292-1"},{"key":"2025092913062752000_9.1.106.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040127"},{"key":"2025092913062752000_9.1.106.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912321"},{"key":"2025092913062752000_9.1.106.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69122-8"},{"key":"2025092913062752000_9.1.106.7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70195-9"},{"key":"2025092913062752000_9.1.106.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60239-5"},{"key":"2025092913062752000_9.1.106.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61009-4"},{"key":"2025092913062752000_9.1.106.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2005.01.012"},{"key":"2025092913062752000_9.1.106.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.021"},{"key":"2025092913062752000_9.1.106.12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000351686","article-title":"Antiplatelet therapy for carotid artery stenting","volume":"1","author":"Enomoto","year":"2013","journal-title":"Interv Neurol"},{"key":"2025092913062752000_9.1.106.13","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0818"},{"key":"2025092913062752000_9.1.106.14","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000341904.39691.2F"},{"key":"2025092913062752000_9.1.106.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.06.004"},{"key":"2025092913062752000_9.1.106.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.101"},{"key":"2025092913062752000_9.1.106.17","doi-asserted-by":"publisher","DOI":"10.5469\/neuroint.2012.7.1.23"},{"key":"2025092913062752000_9.1.106.18","doi-asserted-by":"publisher","DOI":"10.3171\/2014.6.JNS132448"},{"key":"2025092913062752000_9.1.106.19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1160\/TH08-01-0056","article-title":"Clinical implications of aspirin resistance","volume":"100","author":"Zimmermann","year":"2008","journal-title":"Thromb Haemost"},{"key":"2025092913062752000_9.1.106.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03610.x"},{"key":"2025092913062752000_9.1.106.21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0049-3848(92)90220-5","article-title":"Dose-response aggregometry\u2014contribution to the precise platelet function evaluation","volume":"65","author":"Jancinov\u00e1","year":"1992","journal-title":"Thromb Res"},{"key":"2025092913062752000_9.1.106.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02413-3"},{"key":"2025092913062752000_9.1.106.23","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.615708"},{"key":"2025092913062752000_9.1.106.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00191-X"},{"key":"2025092913062752000_9.1.106.25","doi-asserted-by":"publisher","DOI":"10.1583\/06-2036.1"},{"key":"2025092913062752000_9.1.106.26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00836.x"},{"key":"2025092913062752000_9.1.106.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(03)00316-1"},{"key":"2025092913062752000_9.1.106.28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/00015458.2006.11679909","article-title":"Timing of complications during carotid artery stenting. How can they be predicted?","volume":"106","author":"Parlani","year":"2006","journal-title":"Acta Chir Belg"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2016-012419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:06:35Z","timestamp":1759176395000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2016-012419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,1]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,14]]},"published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1136\/neurintsurg-2016-012419"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2016-012419","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,1]]}}}