{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:25:55Z","timestamp":1762017955940,"version":"3.44.0"},"reference-count":22,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2016,10,12]]},"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The benefits of mechanical thrombectomy for emergent large vessel occlusion (ELVO) have been established. Combined mechanical\/aspiration (Solumbra) and a direct aspiration as a first pass technique (ADAPT) are valid procedures requiring an intermediate catheter for clot suction. Recently, SOFIA (Soft torqueable catheter Optimized For Intracranial Access) was developed as a single lumen flexible catheter with coil and braid reinforcement, but its suitability for mechanical thrombectomy had not been evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To describe our initial experience with SOFIA in acute stroke intervention and evaluate its efficacy and safety.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients with ELVO undergoing endovascular stroke intervention with SOFIA were identified. Demographic, presentation, treatment, and complication data were recorded. Primary outcome was Thrombolysis in Cerebral Infarction (TICI) 2b\/3 revascularization rate and the number of passes required. Secondary outcomes included complication rates and discharge National Institute of Health Stroke Scale (NIHSS) score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>33 patients with a mean age of 72\u2005years were treated for ELVO with SOFIA and IV tissue plasminogen activator was administered in 67%. Vessel occlusion involved the internal carotid artery (15.2%), M1 (48.5%), and M2 (24.2%) segments, and posterior circulation (12.1%). Median presentation NIHSS score was 14 (IQR 11\u201319) and discharge NIHSS 4 (IQR 2\u201314). The Solumbra technique represented 94% of treatments and ADAPT 3%. The TICI 2b\/3 revascularization rate was 94%, including 48.5% TICI 3 with an average of 1.6 passes. The symptomatic reperfusion hemorrhage rate was 6%. Procedural complications occurred in four patients, but were unrelated to SOFIA. Mortality was 21%, secondary to failed revascularization, hemorrhagic transformation, and baseline medical condition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Mechanical and aspiration thrombectomy with SOFIA is safe and effective with high revascularization rates. Its trackability, stability, and luminal size make SOFIA suitable for stroke intervention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2016-012750","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T22:33:38Z","timestamp":1477607618000},"page":"1103-1106","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Initial experience with SOFIA as an intermediate catheter in mechanical thrombectomy for acute ischemic stroke"],"prefix":"10.1136","volume":"9","author":[{"given":"Johnny H Y","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Stanford University Hospital, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huy M","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interventional Neuroradiology Division, Stanford University Hospital, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A","family":"Telischak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interventional Neuroradiology Division, Stanford University Hospital, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne M","family":"Moraff","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford University Hospital, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L","family":"Dodd","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford University Hospital, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P","family":"Marks","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interventional Neuroradiology Division, Stanford University Hospital, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya M","family":"Ingle","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interventional Neuroradiology Division, Stanford University Hospital, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1055-8000","authenticated-orcid":false,"given":"Jeremy J","family":"Heit","sequence":"additional","affiliation":[{"name":"Department of Radiology, Interventional Neuroradiology Division, Stanford University Hospital, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"2025092910462400000_9.11.1103.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000152"},{"key":"2025092910462400000_9.11.1103.2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12383"},{"key":"2025092910462400000_9.11.1103.3","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.561787"},{"key":"2025092910462400000_9.11.1103.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"2025092910462400000_9.11.1103.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"2025092910462400000_9.11.1103.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"2025092910462400000_9.11.1103.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"2025092910462400000_9.11.1103.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"2025092910462400000_9.11.1103.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"2025092910462400000_9.11.1103.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15692-4"},{"key":"2025092910462400000_9.11.1103.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"2025092910462400000_9.11.1103.12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1649"},{"key":"2025092910462400000_9.11.1103.13","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70066-3"},{"key":"2025092910462400000_9.11.1103.14","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007935"},{"key":"2025092910462400000_9.11.1103.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2014.11.002"},{"key":"2025092910462400000_9.11.1103.16","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011491"},{"key":"2025092910462400000_9.11.1103.17","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-012122"},{"key":"2025092910462400000_9.11.1103.18","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2013-010713"},{"key":"2025092910462400000_9.11.1103.19","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-011801"},{"key":"2025092910462400000_9.11.1103.20","doi-asserted-by":"publisher","DOI":"10.1177\/1591019916632370"},{"key":"2025092910462400000_9.11.1103.21","doi-asserted-by":"crossref","unstructured":"Stampfl S , Pfaff J , Herweh C , et al . Combined proximal balloon occlusion and distal aspiration: a new approach to prevent distal embolization during neurothrombectomy. J Neurointerv Surg Published Online First: 7 Apr 2016. doi: 10.1136\/neurintsurg-2015-012208","DOI":"10.1136\/neurintsurg-2015-012208"},{"key":"2025092910462400000_9.11.1103.22","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22338"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2016-012750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T17:46:35Z","timestamp":1759167995000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2016-012750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":22,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,10,13]]},"published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1136\/neurintsurg-2016-012750"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2016-012750","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"type":"print","value":"1759-8478"},{"type":"electronic","value":"1759-8486"}],"subject":[],"published":{"date-parts":[[2016,10,27]]}}}