{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:36:44Z","timestamp":1778819804080,"version":"3.51.4"},"reference-count":12,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2017,6,11]]},"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The revascularization of carotid stenosis can increase ipsilateral cerebral blood flow (CBF). Occasionally, elevated CBF is also evident on the contralateral side, but this phenomenon is poorly understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To analyze retrospectively the relationship between a contralateral CBF increase and several clinical and radiologic features.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>We retrospectively analyzed 40 patients with unilateral cervical carotid stenosis treated by carotid artery stenting (CAS). Using <jats:sup>123<\/jats:sup>I-iodamphetamine single-photon emission computed tomography (SPECT); we compared pre- and postoperative hemispheric CBF on both sides. We investigated the influence of the following five factors on the increase of the contralateral hemispheric CBF: stenosis grade (\u226550%\u2009or &lt;50%, according to the North American Symptomatic Carotid Endarterectomy Trial criteria); age; the presence of anterior and posterior communicating arteries; postoperative hyperperfusion on the stenotic side; and the presence of cerebral steal phenomenon during preoperative acetazolamide-challenge SPECT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Following unilateral CAS, mean hemispheric CBF increased significantly on both sides: from 33.4\u00b15.6 (mean \u00b1 SD) to 38.7\u00b17.8\u2009mL\/min on the operated side (paired t test, p&lt;0.001) and f35.4\u00b15.4\u2009to 39.2\u00b17.2\u2009mL\/min on the contralateral side (p&lt;0.001). In a general linear model, stenosis grade (\u226550%) alone was significantly correlated with the increase of the CBF on the contralateral side (p=0.03).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Revascularization by CAS for unilateral carotid stenosis can increase hemispheric CBF on both sides. Increase of the contralateral CBF is correlated with stenosis grade (\u226550%).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2017-013193","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T21:00:33Z","timestamp":1499893233000},"page":"351-354","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Carotid stenting for unilateral stenosis can increase contralateral hemispheric cerebral blood flow"],"prefix":"10.1136","volume":"10","author":[{"given":"Akiyo","family":"Sadato","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Fujita Health University, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nishichita General Hospital, Chita, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoharu","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Fujita Health University, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Fujita Health University, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Toyama","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fujita Health University, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Strokology, Fujita Health University, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Fujita Health University, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"2025092912305045000_10.4.351.1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3250"},{"key":"2025092912305045000_10.4.351.2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600260"},{"key":"2025092912305045000_10.4.351.3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/15910199060120S136","article-title":"Cerebral blood flow\u00a0change before and after carotid angioplasty and stenting (CAS) in cases with contralateral carotid artery occlusion","volume":"12","author":"Kataoka","year":"2006","journal-title":"Interv 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reduction in unilateral stroke: evidence for transhemispheric diaschisis","volume":"18","author":"Lagr\u00e8ze","year":"1987","journal-title":"Stroke"},{"key":"2025092912305045000_10.4.351.11","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000013"},{"key":"2025092912305045000_10.4.351.12","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2930"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2017-013193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:30:57Z","timestamp":1759174257000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2017-013193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,12]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,3,19]]},"published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1136\/neurintsurg-2017-013193"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2017-013193","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,12]]}}}