{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:03:34Z","timestamp":1782259414574,"version":"3.54.5"},"reference-count":26,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2017,10,5]]},"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Studies comparing endovascular stroke treatment using mechanical thrombectomy (MT) with or without prior IV tissue plasminogen activator (tPa) have included only 30% of internal carotid artery terminus occlusions (ICA-O), a known predictor of recanalization failure with IV tPa.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To carry out a retrospective multicenter analysis of prospectively collected data of consecutive patients to investigate the impact of intravenous thrombolysis on ICA-O by comparing patients treated with MT alone or bridging therapy (BT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Material and methods<\/jats:title>\n                  <jats:p>Patients with ICA-O treated with MT alone or BT were retrospectively examined and compared. Demographic data, vascular risk factors, treatment modalities, complications, technical and clinical outcomes were recorded. A propensity score (PS) analysis was used to compare modified Rankin Scale (mRS) score at 3 months and intracerebral hemorrhage (ICH) between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>141 consecutive patients (60% BT\/40%\u2009MT) were included between January 2014 and June 2016. Baseline characteristics did not differ between the groups. There was no significant difference in the rate of Thrombolysis in Cerebral Infarction 2b\/3, distal emboli, and median number of passes between the groups. There was a significant difference between BT and MT groups in the median time between imaging and groin puncture (median 97\u2009min vs 75, p=0.007), the rate of ICH (44% vs 27%, p=0.05), but not for symptomatic ICH (18% vs 13%, p=0.49). With PS, there was a trend towards a higher rate of ICH (OR=2.3, 95% CI 0.9 to 5.9, p=0.09) in the BT group compared with the MT alone group, with no difference in mRS score \u22642 at 3 months (OR=1.6, 95% CI 0.7 to 3.7, p=0.29).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There was no significant difference in clinical outcomes between patients receiving bridging therapy versus direct thrombectomy. Bridging therapy delayed time to groin puncture and increased ICH rate.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2017-013398","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T20:40:43Z","timestamp":1510864843000},"page":"625-628","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Is bridging therapy still required in stroke due to carotid artery terminus occlusions?"],"prefix":"10.1136","volume":"10","author":[{"given":"Romain","family":"Bourcier","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Louis","family":"Alexandre","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Eug\u00e8ne","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital of Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Delasalle-Guyomarch","sequence":"additional","affiliation":[{"name":"Centre d\u2019investigation clinique Thorax, l\u2019Institut du Thorax, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Guillon","sequence":"additional","affiliation":[{"name":"Stroke Unit, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0642-3955","authenticated-orcid":false,"given":"Basile","family":"Kerleroux","sequence":"additional","affiliation":[{"name":"University Hospital of Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Saleme","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-7753","authenticated-orcid":false,"given":"Gaultier","family":"Marnat","sequence":"additional","affiliation":[{"name":"Interventional and Diagnostic Neuroradiology, Bordeaux University Hospital, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy","family":"Boucebci","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital of Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Mirza","sequence":"additional","affiliation":[{"name":"Neuravi Ltd, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Ferr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital of Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9473-9644","authenticated-orcid":false,"given":"Chrysanthi","family":"Papagiannaki","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology, CHU Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Desal","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital of Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"2025092912180658000_10.7.625.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"2025092912180658000_10.7.625.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.01.007"},{"key":"2025092912180658000_10.7.625.3","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-012236"},{"key":"2025092912180658000_10.7.625.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.01.008"},{"key":"2025092912180658000_10.7.625.5","doi-asserted-by":"crossref","unstructured":"Rai AT , Boo S , Buseman C , et al . 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