{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:42:54Z","timestamp":1791434574623,"version":"4.3.3"},"reference-count":26,"publisher":"BMJ","issue":"6","funder":[{"name":"Sequent"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2017,9,15]]},"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Flow disruption with the WEB is an innovative endovascular approach for treatment of wide-neck bifurcation aneurysms. Initial studies have shown a low complication rate with good efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report clinical and anatomical results of the WEB treatment in the cumulative population of three Good Clinical Practice (GCP) studies: WEBCAST (WEB Clinical Assessment of Intrasaccular Aneurysm), French Observatory, and WEBCAST-2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>WEBCAST, French Observatory, and WEBCAST-2 are single-arm, prospective, multicenter, GCP studies dedicated to the evaluation of WEB treatment. Clinical data were independently evaluated. Postoperative and 1-year aneurysm occlusion was independently evaluated using the 3-grade scale: complete occlusion, neck remnant, and aneurysm remnant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cumulative population comprised 168 patients with 169 aneurysms, including 112 female subjects (66.7%). The patients' ages ranged between 27 and 77 years (mean 55.5\u00b110.2 years). Aneurysm locations were middle cerebral artery in 86\/169 aneurysms (50.9%), anterior communicating artery in 36\/169 (21.3%), basilar artery in 30\/169 (17.8%), and internal carotid artery terminus in 17\/169 (10.1%). The aneurysm was ruptured in 14\/169 (8.3%). There was no mortality at 1\u2009month and procedure\/device-related morbidity was 1.2% (2\/168). At 1\u2009year, complete aneurysm occlusion was observed in 81\/153 aneurysms (52.9%), neck remnant in 40\/153 aneurysms (26.1%), and aneurysm remnant in 32\/153 aneurysms (20.9%). Re-treatment was carried out in 6.9%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This series is at the moment the largest prospective, multicenter, GCP series of patients with aneurysms treated with WEB. It shows the high safety and good mid-term efficacy of this treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      French Observatory: Unique identifier (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT18069\" ext-link-type=\"clintrialgov\">NCT18069<\/jats:ext-link>\n                      ); WEBCAST and WEBCAST-2: Unique identifier (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT01778322\" ext-link-type=\"clintrialgov\">NCT01778322<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/neurintsurg-2017-013448","type":"journal-article","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T20:10:13Z","timestamp":1506802213000},"page":"553-559","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":199,"title":["Safety and efficacy of aneurysm treatment with WEB in the cumulative population of three prospective, multicenter series"],"prefix":"10.1136","volume":"10","clinical-trial-number":[{"clinical-trial-number":"nct18069","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct01778322","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Laurent","family":"Pierot","sequence":"first","affiliation":[{"name":"H\u00f4pital Maison-Blanche, Universit\u00e9 Reims-Champagne-Ardenne, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Moret","sequence":"additional","affiliation":[{"name":"H\u00f4pital 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