{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:14:27Z","timestamp":1792858467475,"version":"4.5.0"},"reference-count":19,"publisher":"BMJ","issue":"9","funder":[{"name":"Neuroavi"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2017,12,7]]},"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite advances in revascularization tools for large vessel occlusion presenting as acute ischemic stroke, a significant subset of clots remain recalcitrant to current strategies. We assessed the effectiveness of a novel thrombectomy device that was specifically designed to retrieve resistant fibrin rich clots, the geometric clot extractor (GCE; Neuravi, Galway, Ireland), in an in vitro cerebrovascular occlusion stroke model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After introducing fibrin rich clot analogues into the middle cerebral artery of the model, we compared the rates of recanalization between GCE and Solitaire flow restoration stent retriever (SR; Medtronic, Minneapolis, Minnesota, USA; control group) cases. A maximum of three passes of each device was allowed. If the SR failed to recanalize the vessel after three passes, one pass of the GCE was allowed (rescue cases).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In a total of 26 thrombectomy cases (13 GCE, 13\u2009SR), successful recanalization (Thrombolysis in Cerebral Infarction score of 2b or 3) was achieved 100% of the time in the GCE cases with an average of 2.13 passes per case. This rate was significantly higher compared with the Solitaire recanalization rate (7.7%, P&lt;0.0001) with an average of three passes per case. After SR failure (in 92% of cases), successful one pass GCE rescue recanalization was achieved 66% of the time (P&lt;0.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Application of the GCE in this experimental stroke model to retrieve typically recalcitrant fibrin rich clots resulted in higher successful recanalization rates than the SR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/neurintsurg-2017-013507","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T20:35:14Z","timestamp":1516394114000},"page":"907-910","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["What to do about fibrin rich \u2018tough clots\u2019? Comparing the Solitaire stent retriever with a novel geometric clot extractor in an in vitro stroke model"],"prefix":"10.1136","volume":"10","author":[{"given":"Vernard S","family":"Fennell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetadri Vasan","family":"Setlur Nagesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M","family":"Meess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhys H","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Springer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan H","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"2024052303583038000_10.9.907.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"2024052303583038000_10.9.907.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"2024052303583038000_10.9.907.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"2024052303583038000_10.9.907.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"2024052303583038000_10.9.907.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"2024052303583038000_10.9.907.6","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2842"},{"key":"2024052303583038000_10.9.907.7","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012308"},{"key":"2024052303583038000_10.9.907.8","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.605576"},{"key":"2024052303583038000_10.9.907.9","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011148"},{"key":"2024052303583038000_10.9.907.10","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4149"},{"key":"2024052303583038000_10.9.907.11","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011617"},{"key":"2024052303583038000_10.9.907.12","first-page":"90380M","article-title":"Challenges and limitations of patient-specific vascular phantom fabrication using 3D Polyjet printing","volume":"9038","author":"Ionita","year":"2014","journal-title":"Proc SPIE Int Soc Opt Eng"},{"key":"2024052303583038000_10.9.907.13","first-page":"363","article-title":"Blood-flow volume quantification in internal carotid and vertebral arteries: comparison of 3 different ultrasound techniques with phase-contrast MR imaging","volume":"27","author":"Oktar","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024052303583038000_10.9.907.14","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000278"},{"key":"2024052303583038000_10.9.907.15","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012360"},{"key":"2024052303583038000_10.9.907.16","first-page":"830","article-title":"Mechanical thrombectomy in stroke","volume":"112","author":"Fiehler","year":"2015","journal-title":"Dtsch Arztebl Int"},{"key":"2024052303583038000_10.9.907.17","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4222"},{"key":"2024052303583038000_10.9.907.18","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000230307.03438.94"},{"key":"2024052303583038000_10.9.907.19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/403726","article-title":"Predictors of a good outcome after endovascular stroke treatment with stent retrievers","volume":"2015","author":"Ozdemir","year":"2015","journal-title":"Scientific World Journal"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2017-013507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T07:50:48Z","timestamp":1716450648000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2017-013507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,19]]},"references-count":19,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,8,20]]},"published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1136\/neurintsurg-2017-013507"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2017-013507","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,19]]}}}