{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:21:48Z","timestamp":1791044508389,"version":"4.1.0"},"reference-count":25,"publisher":"BMJ","issue":"1","funder":[{"name":"Medtrinic"},{"name":"Cure4Stroke foundation"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2018,4,26]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the rate of neointimal development and thrombus formation of surface-modified flow diverters in single antiplatelet therapy (SAPT) using optical coherence tomography (OCT) in a porcine model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We divided 10 experimental pigs into two groups. One group (n=6) received dual antiplatelet therapy (DAPT) and the other group (n=4) received SAPT. Four stents (two per carotid artery) were implanted in both groups. The stents used were the Pipeline Flex embolization device (PED Flex), Pipeline Flex with Shield technology (PED Shield), and the Solitaire AB stent. All animals underwent weekly angiography and OCT. The OCT data were analyzed using the following measurements: neointimal ratio ((stent \u2013 lumen area)\/stent area), stent-coverage ratio (number of stent struts covered by neointima\/total\u2009stent struts), and the presence or absence of thrombus formation per 1\u2009mm cross-section.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>PED Flex and Shield in the SAPT group had higher neointimal ratios than in the DAPT group (P&lt;0.001, respectively). In the DAPT group, the speed of endothelial growth on day 7 in the PED Shield group was higher than that in the PED Flex group (P&lt;0.001). In the SAPT group, PED Flex demonstrated significantly more thrombus formation on day 7 than PED Shield (P&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The PED Shield stent showed faster endothelial growth than the other devices and comparable neointimal volume. There was significantly less thrombus formation on PED Shield than PED Flex when using SAPT in a porcine model.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2018-013935","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T12:20:22Z","timestamp":1527337222000},"page":"74-79","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Preliminary outcomes of single antiplatelet therapy for surface-modified flow diverters in an animal model: analysis of neointimal development and thrombus formation using OCT"],"prefix":"10.1136","volume":"11","author":[{"given":"Yoshikazu","family":"Matsuda","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Rush University Medical Center, Chicago, Illinois, USA"},{"name":"Department of Neurosurgery, Wakayama Medical University, Wakayama City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Kyu","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Rush University Medical Center, Chicago, Illinois, USA"},{"name":"Department of Neurosurgery, Incheon St Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonho","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Rush University Medical Center, Chicago, Illinois, USA"},{"name":"Department of Neurosurgery, Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Michael","family":"Wainwright","sequence":"additional","affiliation":[{"name":"Neurovascular R&D, Medtronic, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrius","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,5,26]]},"reference":[{"key":"2025092913354624000_11.1.74.1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4111"},{"key":"2025092913354624000_11.1.74.2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.5.0959"},{"key":"2025092913354624000_11.1.74.3","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2719"},{"key":"2025092913354624000_11.1.74.4","doi-asserted-by":"crossref","first-page":"M853","DOI":"10.1097\/00002480-199407000-00118","article-title":"Biocompatible surfaces using methacryloylphosphorylcholine laurylmethacrylate copolymer","volume":"40","author":"Campbell","year":"1994","journal-title":"Asaio J"},{"key":"2025092913354624000_11.1.74.5","doi-asserted-by":"publisher","DOI":"10.1007\/s100169900013"},{"key":"2025092913354624000_11.1.74.6","doi-asserted-by":"publisher","DOI":"10.1080\/14017439850139843"},{"key":"2025092913354624000_11.1.74.7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1615\/JLongTermEffMedImplants.v12.i4.20","article-title":"Phosphorylcholine-coated stents","volume":"12","author":"Lewis","year":"2002","journal-title":"J Long Term Eff Med Implants"},{"key":"2025092913354624000_11.1.74.8","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.3.338"},{"key":"2025092913354624000_11.1.74.9","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013175"},{"key":"2025092913354624000_11.1.74.10","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012612"},{"key":"2025092913354624000_11.1.74.11","doi-asserted-by":"crossref","unstructured":"Chiu AHY , Ramesh R , Wenderoth J , et al . 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