{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:40:41Z","timestamp":1773211241063,"version":"3.50.1"},"reference-count":14,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2018,8,6]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A stent is often necessary for the treatment of stroke. In such cases,it is essential for the patient to have antiplatelet therapy. There are several methods of antiaggregation, such as oral loading doses of aspirin and clopidogrel, intravenous aspirin, or intravenous glycoprotein IIb\/IIIa receptor antagonists, such as abciximab. The aim of this study was to evaluate the incidence of symptomatic intracerebral hematoma (sICH) associated with our antiplatelet protocol: intravenous abciximab bolus at half the dose (0125\u2009mg\/kg) at the time of the stenting procedure; oral aspirin (150\u2009mg) and clopidogrel (75\u2009mg) daily added the next day after CT shows no significant hematoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Retrospective review of our database of endovascular management of large acute vessel occlusion treated with intravenous abciximab between January 2015 and March 2018. Demographics data, material, drugs, and complications were registered. Fisher tests were used to compare the incidence of sICH in the literature where abciximab 0.25\u2009mg\/kg plus maintenance doses are often administrated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intravenous abciximab was administered to 99 patients. No sICH was observed. According to the European Cooperative Acute Stroke Study Scale, there were 8 cases of hemorrhagic infarction 1, 5 cases of hemorrhagic infarction 2, 4 cases of parenchymal hemorrhage 1, and no cases of parenchymal hemorrhage 2. A comparison between sICH with conventional antiplatelet doses based on the literature showed a statistically significant difference favoring our protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the endovascular treatment of acute ischemic stroke, a bolus dose of 0125\u2009mg\/kg of abciximab with no maintenance doses, followed by 150\u2009mg of aspirin and 75\u2009mg of clopidogrel orally the next day, is safe and effective.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2018-014163","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T21:30:39Z","timestamp":1535491839000},"page":"147-152","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Half bolus dose of intravenous abciximab is safe and effective in the setting of acute stroke endovascular treatment"],"prefix":"10.1136","volume":"11","author":[{"given":"Fernando","family":"Delgado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Oteros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Jimenez-Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Bravo Rey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Dolores","family":"Bautista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Valverde Moyano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"2024052304335430000_11.2.147.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"2024052304335430000_11.2.147.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"2024052304335430000_11.2.147.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"2024052304335430000_11.2.147.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"2024052304335430000_11.2.147.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"2024052304335430000_11.2.147.6","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020072"},{"key":"2024052304335430000_11.2.147.7","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.rx.2017.01.003","article-title":"Intracranial stents in the endovascular treatment of acute ischemic stroke","volume":"59","author":"Delgado Acosta","year":"2017","journal-title":"Radiologia"},{"key":"2024052304335430000_11.2.147.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-014-1353-z"},{"key":"2024052304335430000_11.2.147.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08020-9"},{"key":"2024052304335430000_11.2.147.10","first-page":"CD005208","article-title":"Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke","volume":"3","author":"Ciccone","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"2024052304335430000_11.2.147.11","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"2024052304335430000_11.2.147.12","article-title":"The safety and efficacy of abciximab in acute ischemic stroke: results of the Abciximab in Emergent Stroke Treatment Trial","volume":"52","author":"Adams","year":"2002","journal-title":"Ann\u00a0 Neurol"},{"key":"2024052304335430000_11.2.147.13","doi-asserted-by":"crossref","unstructured":"Forbrig R , Lockau H , Flottmann F , et al . Intracranial rescue stent angioplasty after stent-retriever thrombectomy: multicenter experience. Clin Neuroradiol 2018.doi:10.1007\/s00062-018-0690-4","DOI":"10.1007\/s00062-018-0690-4"},{"key":"2024052304335430000_11.2.147.14","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jns.2018.02.034","article-title":"Emergent carotid artery stenting in atherosclerotic disease of the internal carotid artery with tandem intracranial occlusion","volume":"387","author":"Rodrigues","year":"2018","journal-title":"J Neurol Sci"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2018-014163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T12:09:59Z","timestamp":1716466199000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2018-014163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,28]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,1,21]]},"published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1136\/neurintsurg-2018-014163"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2018-014163","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,28]]}}}