{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:42:30Z","timestamp":1778254950968,"version":"3.51.4"},"reference-count":23,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2018,11,14]]},"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Age, neurologic deficits, core volume (CV), and clinical core or radiographic mismatch are considered in selection for endovascular therapy (ET) in anterior circulation emergent large vessel occlusion (aELVO). Semiquantitative CV estimation by Alberta Stroke Programme Early CT Score (CT ASPECTS) and quantitative CV estimation by CT perfusion (CTP) are both used in selection paradigms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the prognostic value of CTP CV with CT ASPECTS in aELVO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients in an institutional endovascular registry who had aELVO, pre-ET National Institutes of Health Stroke Scale (NIHSS) score, non-contrast CT head and CTP imaging, and prospectively collected 3-month modified Rankin Scale (mRS) score were included. Age- and NIHSS-adjusted models, including either CT ASPECTS or CTP volumes (relative cerebral blood flow &lt;30% of normal tissue, total hypoperfusion, and radiographic mismatch), were compared using receiver operator characteristic analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 508 patients with aELVO (60.8% M1 middle cerebral artery, 34% internal carotid artery, mean age 64.1\u00b115.3 years, median baseline NIHSS score 16 (12\u201320), median baseline CT ASPECTS 8 (7\u20139), mean CV 16.7\u00b124.8\u2009mL). Age, pre-ET NIHSS, CT ASPECTS, CV, hypoperfusion, and perfusion imaging mismatch volumes were predictors of good outcome (mRS score 0\u20132). There were no differences in prognostic accuracies between reference (age, baseline NIHSS, CT ASPECTS; area under the curve (AUC)=0.76) and additional models incorporating combinations of age, NIHSS, and CTP metrics including CV, total hypoperfusion or mismatch volume (AUCs 0.72\u20130.75). Predicted outcomes from CT ASPECTS or CTP CV-based models had excellent agreement (R<jats:sup>2<\/jats:sup>=0.84, p&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Incorporating CTP measures of core or penumbral volume, instead of CT ASPECTS, did not improve prognostication of 3-month outcomes, suggesting prognostic equivalence of CT ASPECTS and CTP CV.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2018-014461","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T15:55:19Z","timestamp":1544198119000},"page":"670-674","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Prognostic importance of CT ASPECTS and CT perfusion measures of infarction in anterior emergent large vessel occlusions"],"prefix":"10.1136","volume":"11","author":[{"given":"Syed Ali","family":"Raza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara M","family":"Barreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel M","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R","family":"Frankel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo C","family":"Haussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul G","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-1500","authenticated-orcid":false,"given":"Srikant","family":"Rangaraju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"2024052304412588000_11.7.670.1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-013792"},{"key":"2024052304412588000_11.7.670.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"2024052304412588000_11.7.670.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"2024052304412588000_11.7.670.4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1706442","article-title":"Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct","volume":"378","author":"Nogueira","year":"2018","journal-title":"N Engl J Med"},{"key":"2024052304412588000_11.7.670.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"2024052304412588000_11.7.670.6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000486539","article-title":"A review of pre-intervention prognostic scores for early prognostication and patient selection in endovascular management of large vessel occlusion stroke","volume":"7","author":"Raza","year":"2018","journal-title":"Interv Neurol"},{"key":"2024052304412588000_11.7.670.7","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011351"},{"key":"2024052304412588000_11.7.670.8","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/1747493016677984","article-title":"Pittsburgh response to endovascular therapy score as a pre-treatment prognostic tool: external validation in Trevo2","volume":"12","author":"Ali Raza","year":"2017","journal-title":"Int J 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therapy","volume":"44","author":"Bouslama","year":"2017","journal-title":"Cerebrovasc Dis"},{"key":"2024052304412588000_11.7.670.17","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.618355"},{"key":"2024052304412588000_11.7.670.18","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"2024052304412588000_11.7.670.19","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1212\/WNL.0000000000004028","article-title":"Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core 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