{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:58:01Z","timestamp":1791021481843,"version":"4.1.0"},"reference-count":24,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2019,1,9]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the cumulative incidence of restenosis and stroke after stenting for cervical carotid artery stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed PubMed, ScienceDirect, and Scopus and included all studies reporting restenosis after stenting. The cumulative incidence of restenosis at 6 and 12 months was calculated. We also estimated the cumulative incidence of ipsilateral stroke within 30 days after stenting. Random effect meta-analysis and meta-regression were performed using relevant study level covariates. Sources of heterogeneity were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 7765 records, 40 studies were selected. 15 943 patients and 16 337 carotid arteries were considered. The overall pooled cumulative incidence of restenosis &gt;50% at 12 months was 5.7% (95% CI 3.8% to 8.6%), &gt;70% at 12 months was 5.2% (95% CI 3.3% to 8.2%), &gt;50% at 6 months was 3.9% (95% CI 2.2% to 6.8%), and ipsilateral stroke within 30 days after stenting was 1.6% (95% CI 1.0% to 2.5%) without association with the use of an embolic protection device. We did not identify any relevant source of heterogeneity of the cumulative incidence of restenosis &gt;50% at 12 months. Mean age explained 80.9% (R<jats:sup>2<\/jats:sup>=80.9%, p=0.01) of heterogeneities of restenosis &gt;70% at 12 months. The presence of hostile neck explained 53.9% (R<jats:sup>2<\/jats:sup>=53.9%, p=0.03) of heterogeneities of restenosis &gt;50% at 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta-analysis showed a low cumulative rate of restenosis at 12 months and ipsilateral stroke within 30 days after stenting. Older patients and those with hostile neck present a lower risk of in-stent restenosis. The use of an embolic protection device was not associated with a lower risk of stroke.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2018-014534","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T22:19:30Z","timestamp":1548973170000},"page":"916-923","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Cumulative incidence of restenosis in the endovascular treatment of extracranial carotid artery stenosis: a meta-analysis"],"prefix":"10.1136","volume":"11","author":[{"given":"Pierre","family":"Clavel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Saleme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charbel","family":"Mounayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-3375","authenticated-orcid":false,"given":"Aymeric","family":"Rouchaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"2024052304430092000_11.9.916.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.9.1751"},{"key":"2024052304430092000_11.9.916.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912321"},{"key":"2024052304430092000_11.9.916.3","doi-asserted-by":"crossref","unstructured":"Borenstein M , Hedges L , Higgins J , et al . 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