{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:16:35Z","timestamp":1782270995653,"version":"3.54.5"},"reference-count":33,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2019,5,3]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Acute basilar artery occlusion (BAO) is a devastating disease with a high rate of mortality and morbidity, and early recanalization is crucial to achieve a good prognosis. The best treatment strategy for BAO combined with a proximal stenosis (tandem occlusion) is not yet clear. Our study aimed to evaluate whether and how vertebrobasilar tandem occlusions can be treated effectively and safely compared with isolated BAO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Fifty-two patients with acute vertebrobasilar occlusive stroke treated with mechanical thrombectomy were identified in a prospective database from March 2010 to September 2016. We retrospectively analysed the clinical, technical, and functional outcomes of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 52 patients, 15 presented with a tandem occlusion, 14 with a single intracranial occlusion due to an underlying stenosis, and 23 with a single embolic BAO. Successful recanalization was achieved in all of the patients with tandem occlusions (modified Thrombolysis in Cranial Infarction 2b\/3) and in 35 of 37 patients with a single BAO (with and without stenosis). A favourable outcome was achieved (modified Rankin Scale \u22642) in 8 of the 15 patients with a tandem occlusion compared with 4 of the 14 patients with a single BAO with underlying stenosis and 5 of the 23 patients with isolated embolic BAO (p=0.18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We suggest that endovascular treatment of vertebrobasilar tandem occlusions is safe and feasible, with a high rate of good outcome.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2019-014825","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T21:55:02Z","timestamp":1558475702000},"page":"25-29","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Endovascular treatment of tandem occlusions in vertebrobasilar stroke: technical aspects and outcome compared with isolated basilar artery occlusion"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5609-0998","authenticated-orcid":false,"given":"Eike I","family":"Piechowiak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kaesmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Zibold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6167-3343","authenticated-orcid":false,"given":"Tomas","family":"Dobrocky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal J","family":"Mosimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Bellwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam R","family":"Heldner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gralla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Mordasini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"2024111103201055000_12.1.25.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"2024111103201055000_12.1.25.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"2024111103201055000_12.1.25.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"2024111103201055000_12.1.25.4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00330-016-4338-y","article-title":"Stent-retriever thrombectomy for acute anterior ischemic stroke with tandem occlusion: a systematic review and meta-analysis","volume":"27","author":"Sivan-Hoffmann","year":"2017","journal-title":"Eur Radiol"},{"key":"2024111103201055000_12.1.25.5","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3168"},{"key":"2024111103201055000_12.1.25.6","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1001\/jamaneurol.2016.1408","article-title":"Safety and outcome of intra-arterial treatment for basilar artery occlusion","volume":"73","author":"van Houwelingen","year":"2016","journal-title":"JAMA Neurol"},{"key":"2024111103201055000_12.1.25.7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-310250"},{"key":"2024111103201055000_12.1.25.8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10143-015-0693-4","article-title":"Intra-arterial revascularization therapy for basilar artery occlusion-a systematic review and analysis","volume":"39","author":"Mak","year":"2016","journal-title":"Neurosurg Rev"},{"key":"2024111103201055000_12.1.25.9","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-012089"},{"key":"2024111103201055000_12.1.25.10","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.pjnns.2017.07.012","article-title":"Treatment of acute basilar artery occlusion: systematic review and meta-analysis","volume":"51","author":"Wyszomirski","year":"2017","journal-title":"Neurol Neurochir Pol"},{"key":"2024111103201055000_12.1.25.11","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70229-0"},{"key":"2024111103201055000_12.1.25.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.7.1389"},{"key":"2024111103201055000_12.1.25.13","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000057744.96295.9F"},{"key":"2024111103201055000_12.1.25.14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s00415-014-7583-5","article-title":"Vertebral artery stenosis in the Basilar Artery International Cooperation Study (BASICS): prevalence and outcome","volume":"262","author":"Compter","year":"2015","journal-title":"J Neurol"},{"key":"2024111103201055000_12.1.25.15","doi-asserted-by":"publisher","DOI":"10.15274\/INR-2014-10022"},{"key":"2024111103201055000_12.1.25.16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jocn.2016.05.005","article-title":"Emergent revascularization of acute tandem vertebrobasilar occlusions: Endovascular approaches and technical considerations-Confirming the role of vertebral artery ostium stenosis as a cause of vertebrobasilar stroke","volume":"34","author":"Cohen","year":"2016","journal-title":"J Clin Neurosci"},{"key":"2024111103201055000_12.1.25.17","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2013-010719"},{"key":"2024111103201055000_12.1.25.18","doi-asserted-by":"crossref","unstructured":"Siebert E , Bohner G , Zweynert S , et al . Revascularization techniques for acute basilar artery occlusion: technical considerations and outcome in the setting of severe posterior circulation steno-occlusive disease. Clin Neuroradiol 2018.doi:10.1007\/s00062-018-0683-3","DOI":"10.1007\/s00062-018-0683-3"},{"key":"2024111103201055000_12.1.25.19","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2017-000125"},{"key":"2024111103201055000_12.1.25.20","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001972"},{"key":"2024111103201055000_12.1.25.21","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4529"},{"key":"2024111103201055000_12.1.25.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08020-9"},{"key":"2024111103201055000_12.1.25.23","first-page":"545","article-title":"[Occlusion of the basilar artery. A review with 17 personal cases (author\u2019s transl)]","volume":"137","author":"Labauge","year":"1981","journal-title":"Rev Neurol"},{"key":"2024111103201055000_12.1.25.24","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.526566"},{"key":"2024111103201055000_12.1.25.25","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012797"},{"key":"2024111103201055000_12.1.25.26","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012634"},{"key":"2024111103201055000_12.1.25.27","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.608976"},{"key":"2024111103201055000_12.1.25.28","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013707"},{"key":"2024111103201055000_12.1.25.29","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-014-1465-5"},{"key":"2024111103201055000_12.1.25.30","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015150575"},{"key":"2024111103201055000_12.1.25.31","doi-asserted-by":"publisher","DOI":"10.3171\/2008.11.JNS081035"},{"key":"2024111103201055000_12.1.25.32","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824e8f40"},{"key":"2024111103201055000_12.1.25.33","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4844"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2019-014825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T11:21:20Z","timestamp":1731324080000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2019-014825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,21]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12,20]]},"published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1136\/neurintsurg-2019-014825"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2019-014825","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,21]]}}}