{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:20:12Z","timestamp":1790328012457,"version":"4.1.0"},"reference-count":24,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2019,10,28]]},"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                  <jats:title>\u200bBackground and purpose<\/jats:title>\n                  <jats:p>Intracranial aneurysms are a frequently occurring disease, with an estimated prevalence of 2\u20135% in the general population. They usually remain silent until rupture occurs, with a mortality rate of 35\u201350%\u2009and a high rate of morbidity, including long-term disability. However, preventative treatments have their own risk of complications and morbi-mortality rates, including stroke and hemorrhage. ECG-gated four-dimensional CT angiography (4D-CTA) allows the acquisition of time-resolved three-dimensional reconstructions. The aim of our study was to evaluate different intracranial aneurysm metrics over the cardiac cycle using ECG-gated 4D-CTA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>\u200bMaterials and methods<\/jats:title>\n                  <jats:p>ECG-gated 4D-CTA datasets were acquired in patients presenting with intracranial aneurysms. Seven aneurysm metrics, including aneurysm height, aneurysm length, ostium width, aspect ratio, ostium area, volume, and volume-to-ostium ratio, were analysed over different cardiac phases. Intra-reader agreement, inter-reader agreement, and inter-cycle agreement were calculated through the intraclass correlation coefficient.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>\u200bResults<\/jats:title>\n                  <jats:p>Twenty-one aneurysms from 11 patients were considered for inclusion. Post-processing failed for three aneurysms, and 18 aneurysms were finally analysed. There was good intra-reader agreement for each metric (ICC &gt;0.9). Agreements among three consecutive cardiac cycles were calculated for six aneurysms and were especially good for the volume metric (ICC &gt;0.9). Volume variation appears to be the most relevant metric and seems especially perceptible for aneurysms larger than 5\u2009mm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>\u200bConclusions<\/jats:title>\n                  <jats:p>Quantification of aneurysm volume changes during the cardiac cycle seems quantitatively possible and reproducible, especially for aneurysms larger than 5\u2009mm. Further studies need to be conducted to validate this parameter for intracranial aneurysm assessment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2019-015336","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T17:15:41Z","timestamp":1573146941000},"page":"632-636","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Volume variation may be a relevant metric in the study of aneurysm pulsatility: a study using ECG-gated 4D-CTA (PULSAN)"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct03535181","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9903-9567","authenticated-orcid":false,"given":"Brieg","family":"Dissaux","sequence":"first","affiliation":[{"name":"Neuroradiology Department, CHRU de la Cavale Blanche, Brest, France"},{"name":"Groupement d'Etude de la Thrombose en Bretagne Occidentale - 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New French diagnostic reference levels: let\u2019s take stock of our daily practices! J Neuroradiol 2019. 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