{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:16:49Z","timestamp":1775686609623,"version":"3.50.1"},"reference-count":15,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2019,12,22]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Advanced Thrombectomy System (ANCD) provides a new funnel component designed to reduce clot fragmentation and facilitate retrieval in patients with stroke by locally restricting flow, allowing distal aspiration in combination with a stent retriever (SR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the preclinical efficacy and safety of the ANCD in a swine clot model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Soft and firm clots were implanted in the lingual and cervical arteries of 11 swine to obtain Thrombolysis in Cerebral Infarction (TICI) 0 blood flow. Mechanical thrombectomy was performed with either a balloon guide catheter+Solitaire 2 stent retriever (BGC+SR, n=13) or ANCD+SR (n=13). TICI flow was evaluated and successful revascularization was defined as TICI 3 (normal perfusion). To characterize safety, a total of 3 passes were performed in each vessel independent of recanalization. Tissues were explanted for histopathological analysis after 3 and 30 days, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>First pass reperfusion rates were ANCD+SR: 69% and BGC+SR: 46%. Reperfusion increased after the third pass in both groups (ANCD+SR: 100%, vs BGC+SR: 77%). Recanalization was achieved after an average of 1.4 and 1.9 passes in ANCD+SR\u2009and BGC+SR (p=0.095), respectively. Vessel injury was comparable in both groups; endothelial loss at 3 days was the most common injury seen (ANCD+SR: 1.78\u00b11.22; BGC+SR: 2.03\u00b11.20; p=0.73), while other histopathological markers were absent or minimal. Tissues downstream from targeted vessels also showed absence or minimal lesions across both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results in a swine clot model support the high efficacy of the ANCD+SR without causing clinically significant vessel injury potentially related to the new funnel component.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2019-015548","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T22:26:48Z","timestamp":1579559208000},"page":"1008-1013","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Preclinical evaluation of the ANCD thrombectomy device: safety and efficacy in a swine clot model"],"prefix":"10.1136","volume":"12","author":[{"given":"Sonia","family":"Sanchez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Ducore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommy","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Cognard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ribo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Villanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u00f1aki","family":"Galve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"2024111103251082000_12.10.1008.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"2024111103251082000_12.10.1008.2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/neurintsurg-2018-014127","article-title":"eTICI reperfusion: defining success in endovascular stroke therapy","volume":"11","author":"Liebeskind","year":"2018","journal-title":"J Neurointerv Surg"},{"key":"2024111103251082000_12.10.1008.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13647"},{"key":"2024111103251082000_12.10.1008.4","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1161\/STROKEAHA.119.025088","article-title":"When to stop","volume":"50","author":"Garc\u00eda-Tornel","year":"2019","journal-title":"Stroke"},{"key":"2024111103251082000_12.10.1008.5","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020315"},{"key":"2024111103251082000_12.10.1008.6","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-012218"},{"key":"2024111103251082000_12.10.1008.7","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-014856"},{"key":"2024111103251082000_12.10.1008.8","unstructured":"United States Code . Animal welfare act. title 7 agriculture. Chapter 54 transportation, sale, and handling of certain animals; sections 2131 \u2013 2159. Available: http:\/\/www.gpo.gov\/fdsys\/pkg\/USCODE-2012-title7\/html\/USCODE-2012-title7-chap54.htm [Accessed 24 Jan 2014]."},{"key":"2024111103251082000_12.10.1008.9","unstructured":"Code of Federal Regulations . Animal Welfare Regulations. Title 9 \u2013 Animals and Animal Products. Chapter 1 - Animal and Plant Health Inspection Service, Department of Agriculture. Subchapter A - Animal Welfare; Parts 1, 2, and 3. 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