{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:51:40Z","timestamp":1790617900959,"version":"4.1.0"},"reference-count":29,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2020,2,15]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hemodynamic alterations post-embolization of intracranial arteriovenous malformations (AVMs) may cause delayed edema\/hemorrhage in brain parenchyma adjacent to the lesion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To quantify and compare cerebral perfusion changes in the peri-AVM territory pre- and post-embolization using color-coded quantitative digital subtraction angiography (q-DSA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Pediatric intracranial AVM embolization procedures performed over a 5\u2009year period were included. DSA images of all patients were retrospectively assessed using <jats:italic>syngo<\/jats:italic> iFlow. Regions of interest (ROI) were selected on anteroposterior and lateral q-DSA views: three in the peri-AVM region; two in parenchyma distant from the AVM. Time-to-peak (TTP) contrast enhancement of ROIs and \u2206TTP (TTP at the selected ROI minus TTP at either the ipsilateral internal carotid\/vertebral artery) were measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Result<\/jats:title>\n                  <jats:p>19 pediatric patients with 19 AVMs (9 males\/10 females, mean age 12\u2009years) underwent intracranial AVM embolization: 15\/19 AVMs were supplied by the anterior circulation and 4\/19 by the posterior circulation. Blood flow was significantly slower post-embolization in the draining vein (19\/19) (p&lt;0.01), and the venous sinus outflow (17\/19) (p&lt;0.01), by mean difference of 2.01\u00b11.31\u2009s and 1.74\u00b12.04\u2009s. There was significantly increased peri-AVM parenchymal perfusion post-embolization (\u2206TTP=2.20\u00b10.48\u2009s) compared with pre-embolization (\u2206TTP=2.52\u00b10.42\u2009s), by an average \u2206TTP of 0.33\u00b10.53\u2009s (p=0.014). In contrast, there was no perfusion difference (\u2206TTP=0.03\u00b10.20\u2009s, p=0.8) between pre- and post-embolization in the distant parenchyma. The size of the AVM was not correlated with change in peri-nidal parenchymal perfusion (r=\u22120.136, p=0.579).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study demonstrates more rapid perfusion in the peri-nidal brain parenchyma post-embolization of the AVM, which supports the theory that increased perfusion in normal tissue surrounding the AVM after embolization may underlie some post-procedural complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2019-015776","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T17:16:02Z","timestamp":1584551762000},"page":"902-905","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Association of intracranial arteriovenous malformation embolization with more rapid rate of perfusion in the peri-nidal region on 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