{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:42:01Z","timestamp":1784155321300,"version":"3.55.0"},"reference-count":28,"publisher":"BMJ","issue":"4","funder":[{"name":"Microvention Terumo Inc"},{"name":"Newcastle University Biomedical Research Centre"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Study was a PROBE design phase II randomized controlled trial (RCT).\n                            We assessed trial feasibility and technical efficacy and safety of two\n                            novel thrombectomy devices \u2013 ERIC (a retriever device) and SOFIA (a\n                            distal access catheter) \u2013 used alone or in combination depending on\n                            operator preference.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Four UK neuroscience centers enrolled adults with proximal large\n                            artery occlusion (LAO) stroke on imaging where arterial puncture was\n                            achievable within 5.5 hours (8.5 hours for posterior circulation) of\n                            symptom onset; National Institutes of Health Stroke Scale (NIHSS) \u22656\n                            with limited ischemic change on CT imaging. Randomization was 2:1 into\n                            intervention arm (ERIC and\/or SOFIA). Patients and core lab were blinded\n                            to allocation. Primary outcome was independent core lab adjudication of\n                            reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI)\n                            scale). Secondary outcomes were modified Rankin score (mRS) at 90 and\n                            365 days (independence and shift analysis), 30-day mortality,\n                            symptomatic intracranial hemorrhage (sICH), procedural complications and\n                            NIHSS change.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Sixty-six patients were enrolled. TICI 2B\/3 reperfusion was achieved\n                            in 72% in intervention compared with 90% in control arm on intention to\n                            treat (ITT) analysis (P=0.2) and 78% compared with 86% on per protocol\n                            analysis (P=0.7). Functional independence at 90 days was 40%\n                            (intervention) compared with 43% (control) on ITT analysis (P=1.0). sICH\n                            rates were low at 0% and 5%, respectively (P=0.3). The 30-day mortality\n                            was 9% intervention compared with 14% control (P=0.7).<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>Study indicated feasibility of a phase II RCT trial approach for\n                            assessing new thrombectomy devices. In a broad LAO stroke population\n                            ERIC and SOFIA were not statistically different from control devices.\n                            Larger trials are needed.<\/jats:p>\n                    <\/jats:sec>","DOI":"10.1136\/neurintsurg-2020-016038","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T16:59:21Z","timestamp":1615827561000},"page":"311-318","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of stroke thrombectomy including patients where IV\n                        thrombolysis is contraindicated or has failed: a randomized trial of two\n                        novel thrombectomy devices"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"isrctn15698516","registry":"10.18810\/isrctn"}],"author":[{"given":"Philip M","family":"White","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Gregson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1663-6658","authenticated-orcid":false,"given":"Elena Adela","family":"Cora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogish","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Simister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Lakey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Maiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"2021031502450557000_13.4.311.1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.592535"},{"key":"2021031502450557000_13.4.311.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60584-5"},{"key":"2021031502450557000_13.4.311.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"2021031502450557000_13.4.311.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13647"},{"key":"2021031502450557000_13.4.311.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"2021031502450557000_13.4.311.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"2021031502450557000_13.4.311.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"2021031502450557000_13.4.311.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"2021031502450557000_13.4.311.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"2021031502450557000_13.4.311.10","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30177-6"},{"key":"2021031502450557000_13.4.311.11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314117"},{"key":"2021031502450557000_13.4.311.12","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013372"},{"key":"2021031502450557000_13.4.311.13","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012379"},{"key":"2021031502450557000_13.4.311.14","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5201"},{"key":"2021031502450557000_13.4.311.15","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-011801"},{"key":"2021031502450557000_13.4.311.16","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4463"},{"key":"2021031502450557000_13.4.311.17","unstructured":"Sentinel stroke national audit programme clinical\n                            audit April 2013-March, 2018. Available:\n                            https:\/\/www.strokeaudit.org\/Documents\/National\/Clinical\/Apr2017Mar2018\/Apr2017Mar2018-AnnualReport.aspx\n                            [Accessed 30 Aug 2019]."},{"key":"2021031502450557000_13.4.311.18","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.674622"},{"key":"2021031502450557000_13.4.311.19","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002015"},{"key":"2021031502450557000_13.4.311.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60149-4"},{"key":"2021031502450557000_13.4.311.21","doi-asserted-by":"publisher","DOI":"10.1002\/sim.721"},{"key":"2021031502450557000_13.4.311.22","doi-asserted-by":"publisher","DOI":"10.1177\/2396987317733343"},{"key":"2021031502450557000_13.4.311.23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.16623"},{"key":"2021031502450557000_13.4.311.24","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1001\/jamaneurol.2017.4474","article-title":"Effect of general anesthesia and conscious sedation during endovascular therapy on infarct growth and clinical outcomes in acute ischemic stroke: a randomized clinical trial","volume":"75","author":"Simonsen","year":"2018","journal-title":"JAMA Neurol"},{"key":"2021031502450557000_13.4.311.25","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016554"},{"key":"2021031502450557000_13.4.311.26","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30407-6"},{"key":"2021031502450557000_13.4.311.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30297-1"},{"key":"2021031502450557000_13.4.311.28","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1161\/STROKEAHA.119.024858","article-title":"ERASER: a thrombectomy study with predictive analytics end point","volume":"50","author":"Fiehler","year":"2019","journal-title":"Stroke"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2020-016038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T16:59:38Z","timestamp":1615827578000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2020-016038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,14]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,3,15]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/neurintsurg-2020-016038"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2020-016038","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,14]]}}}