{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:47:55Z","timestamp":1783334875457,"version":"3.54.6"},"reference-count":28,"publisher":"BMJ","issue":"9","funder":[{"name":"National Key Research and Development","award":["2016YFC1301703"],"award-info":[{"award-number":["2016YFC1301703"]}]},{"name":"Beijing Municipal Commission of Science and Technology","award":["Z201100005520020"],"award-info":[{"award-number":["Z201100005520020"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2020,9,14]]},"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Drug-coated balloon (DCB) is a potential treatment for patients with low restenosis risk in vertebral artery origin stenosis (VAOS). However, the clinical data of long-term outcome are limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the safety and efficacy of a DCB in patients with severe VAOS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective, non-randomized, single-center pilot study enrolled 30 patients with severe VAOS treated with DCB between 2017 and 2018. The first 20 patients were treated with a balloon-to-vessel ratio of predilation (pBVR)\uff1c0.8 (small-size balloon predilation) and the following 10 patients were treated with a pBVR 0.8\u20131.0 (large-size balloon predilation). Primary safety endpoints included 30-day death, stroke, and transient ischemic attack (TIA). The main efficacy outcome was restenosis at 6 months, defined as a peak systolic velocity &gt;140 cm\/s measured by Doppler ultrasound. Long-term outcomes, including TIAs, stroke, death, and modified Rankin Scale score, were followed up to 2 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Technical success (&lt;50% residual stenosis) was achieved in 26 patients (mean age 66.2\u00b17.0; seven women). Four patients received bailout stenting and were excluded. Ultrasound confirmed restenosis at 6 months in 10 (38.5%) of 26, which was significantly less frequent in LSBP (LSBP vs SSBP=10% vs 56.3%, p&lt;0.05). No adverse events occurred within 30 days of treatment. 19 patients were followed up for 2 years, with two deaths due to cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This pilot study suggests that DCB is a safe approach for VAOS. The relatively low restenosis rate indicates the its potential long-term efficacy for VAOS. Future randomized controlled trials to confirm its efficacy are warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2020-016723","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T17:21:48Z","timestamp":1602868908000},"page":"827-830","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Drug-coated balloon for vertebral artery origin stenosis: a pilot study"],"prefix":"10.1136","volume":"13","author":[{"given":"Yabing","family":"Wang","sequence":"first","affiliation":[{"name":"China International Neuroscience Institute (China-INI), Beijing, China"},{"name":"Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 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