{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:49:45Z","timestamp":1792802985204,"version":"4.5.0"},"reference-count":29,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS105853"],"award-info":[{"award-number":["R01 NS105853"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["13\/RC\/2073"],"award-info":[{"award-number":["13\/RC\/2073"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2020,11,20]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic strokes are associated with shorter clot lengths and lower clot burden than non-cardioembolic clots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report the relationship between stroke etiology, extracted clot area, and histological composition at each procedural pass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>As part of the multi-institutional RESTORE Registry, the Martius Scarlett Blue stained histological composition and extracted clot area of 612 per-pass clots retrieved from 441 patients during mechanical thrombectomy procedures were quantified. Correlations with clinical and procedural details were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clot composition varied significantly with procedural passes; clots retrieved in earlier passes had higher red blood cell content (H4=11.644, p=0.020) and larger extracted clot area (H4=10.730, p=0.030). Later passes were associated with significantly higher fibrin (H4=12.935, p=0.012) and platelets\/other (H4=15.977, p=0.003) content and smaller extracted clot area. Large artery atherosclerotic (LAA) clots were significantly larger in the extracted clot area and more red blood cell-rich than other etiologies in passes 1\u20133. Cardioembolic and cryptogenic clots had similar histological composition and extracted clot area across all procedural passes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LAA clots are larger and associated with a large red blood cell-rich extracted clot area, suggesting soft thrombus material. Cardioembolic clots are smaller in the extracted clot area, consistent in composition and area across passes, and have higher fibrin and platelets\/other content than LAA clots, making them stiffer clots. The per-pass histological composition and extracted clot area of cryptogenic clots are similar to those of cardioembolic clots, suggesting similar formation mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/neurintsurg-2020-016966","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T17:34:36Z","timestamp":1607535276000},"page":"1111-1116","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6634-092X","authenticated-orcid":false,"given":"Se\u00e1n","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"Department of Physiology, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3656-2908","authenticated-orcid":false,"given":"Rosanna","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Physiology, National University of Ireland Galway, Galway, Ireland"},{"name":"C\u00daRAM - SFI Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-3784","authenticated-orcid":false,"given":"Oana Madalina","family":"Mereuta","sequence":"additional","affiliation":[{"name":"Department of Physiology, National University of Ireland Galway, Galway, Ireland"},{"name":"C\u00daRAM - SFI Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duaa","family":"Jabrah","sequence":"additional","affiliation":[{"name":"Department of Physiology, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaobi","family":"Okolo","sequence":"additional","affiliation":[{"name":"Department of Physiology, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Physiology, National University of Ireland Galway, Galway, Ireland"},{"name":"C\u00daRAM - SFI Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Molina Gil","sequence":"additional","affiliation":[{"name":"Department of Physiology, National University of Ireland Galway, Galway, Ireland"},{"name":"C\u00daRAM - SFI Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Pandit","sequence":"additional","affiliation":[{"name":"C\u00daRAM - SFI Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Cerenovus, Galway Neuro Technology Centre, Johnson and Johnson Medical Devices, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gilvarry","sequence":"additional","affiliation":[{"name":"Cerenovus, Galway Neuro Technology Centre, Johnson and Johnson Medical Devices, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Dunker","sequence":"additional","affiliation":[{"name":"Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"},{"name":"Department of Radiology, University of Gothenburg Institute of Clinical Sciences, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Nordanstig","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"},{"name":"Department of Clinical Neuroscience, University of Gothenburg Institute of Neuroscience and Physiology, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Ceder","sequence":"additional","affiliation":[{"name":"Department of Interventional and Diagnostic Neuroradiology, Sahlgrenska University Hospital, G\u00f6teborg, 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