{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:11:46Z","timestamp":1793167906360,"version":"4.5.0"},"reference-count":18,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2021,1,15]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The benefit of complete reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 3) over near-complete reperfusion (\u226590%, mTICI 2c) remains unclear. The goal of this study is to compare clinical outcomes between mechanical thrombectomy (MT)-treated stroke patients with mTICI 2c versus 3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a retrospective study from the Stroke Thrombectomy and Aneurysm Registry (STAR) comprising 33 centers. Adults with anterior circulation arterial vessel occlusion who underwent MT yielding mTICI 2c or mTICI 3 reperfusion were included. Patients were categorized based on reperfusion grade achieved. Primary outcome was modified Rankin Scale (mRS) 0\u20132 at 90 days. Secondary outcomes were mRS scores at discharge and 90 days, National Institutes of Health Stroke Scale score at discharge, procedure-related complications, and symptomatic intracerebral hemorrhage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The unmatched mTICI 2c and mTICI 3 cohorts comprised 519 and 1923 patients, respectively. There was no difference in primary (42.4% vs 45.1%; p=0.264) or secondary outcomes between the unmatched cohorts. Reperfusion status (mTICI 2c vs 3) was also not predictive of the primary outcome in non-imputed and imputed multivariable models. The matched cohorts each comprised 191 patients. Primary (39.8% vs 47.6%; p=0.122) and secondary outcomes were also similar between the matched cohorts, except the 90-day mRS which was lower in the matched mTICI 3 cohort (p=0.049). There were increased odds of the primary outcome with mTICI 3 in patients with baseline mRS \u22652 (36% vs 7.7%; p=0.011; p<jats:sub>interaction<\/jats:sub>=0.014) and a history of stroke (42.3% vs 15.4%; p=0.027; p<jats:sub>interaction<\/jats:sub>=0.041).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Complete and near-complete reperfusion after MT appear to confer comparable outcomes in patients with acute stroke.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2020-017193","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T11:08:25Z","timestamp":1613560105000},"page":"111-116","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Is a picture-perfect thrombectomy necessary in acute ischemic stroke?"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-9273","authenticated-orcid":false,"given":"Ching-Jen","family":"Chen","sequence":"first","affiliation":[{"name":"Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-6359","authenticated-orcid":false,"given":"Reda","family":"Chalhoub","sequence":"additional","affiliation":[{"name":"Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2627-446X","authenticated-orcid":false,"given":"Dale","family":"Ding","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeyan S","family":"Kumar","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Ironside","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6491-5443","authenticated-orcid":false,"given":"Ryan T","family":"Kellogg","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford B","family":"Worrall","sequence":"additional","affiliation":[{"name":"Neurology, University of Virginia Health System, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M","family":"Southerland","sequence":"additional","affiliation":[{"name":"Neurology, University of Virginia Health System, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1544-4910","authenticated-orcid":false,"given":"Pascal","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Neurological Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-2728","authenticated-orcid":false,"given":"Stacey Q","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Neurosurgery, Wake Forest School of Medicine, Winston Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-1613","authenticated-orcid":false,"given":"Adam S","family":"Arthur","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Goyal","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA"},{"name":"Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Fragata","sequence":"additional","affiliation":[{"name":"Neuroradiology, Centro Hospitalar de Lisboa Central, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-8878","authenticated-orcid":false,"given":"Ilko","family":"Maier","sequence":"additional","affiliation":[{"name":"Neurology, University Medicine Goettingen, Goettingen, NS, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Matouk","sequence":"additional","affiliation":[{"name":"Neurosurgery, Yale University, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1152-8826","authenticated-orcid":false,"given":"Jonathan A","family":"Grossberg","sequence":"additional","affiliation":[{"name":"Neurosurgery and Radiology, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6649-4128","authenticated-orcid":false,"given":"Peter","family":"Kan","sequence":"additional","affiliation":[{"name":"Neurosurgery, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-8781","authenticated-orcid":false,"given":"Clemens M","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Neurosurgery, Geisinger Health System, Wilkes-Barre, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Webster","family":"Crowley","sequence":"additional","affiliation":[{"name":"Neurosurgery, Rush University, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0978-074X","authenticated-orcid":false,"given":"William J","family":"Ares","sequence":"additional","affiliation":[{"name":"Neurosurgery, NorthShore University HealthSystem, Evanston, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S","family":"Ogilvy","sequence":"additional","affiliation":[{"name":"Neurosurgery, BIDMC, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-4805","authenticated-orcid":false,"given":"Ansaar T","family":"Rai","sequence":"additional","affiliation":[{"name":"Neurointerventional Radiology, West Virginia University, Morgantown, West Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-3347","authenticated-orcid":false,"given":"Michael R","family":"Levitt","sequence":"additional","affiliation":[{"name":"Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Mokin","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of South Florida, Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldo R","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of South Florida, Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R","family":"Mascitelli","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J","family":"Yoo","sequence":"additional","affiliation":[{"name":"Neurointerventional Radiology, Texas Stroke Institute, Plano, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Williamson","sequence":"additional","affiliation":[{"name":"Neurosurgery, Baptist Medical Center Jacksonville, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Walker","family":"Grande","sequence":"additional","affiliation":[{"name":"Neurosurgery, Radiology and Neurology, University of Minnesota, Mendota Heights, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-2161","authenticated-orcid":false,"given":"Roberto Javier","family":"Crosa","sequence":"additional","affiliation":[{"name":"Endovascular Neurosurgery, M\u00e9dica Uruguaya, Montevideo, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Webb","sequence":"additional","affiliation":[{"name":"Neurosurgery, Bon Secours, Greenville, South Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios N","family":"Psychogios","sequence":"additional","affiliation":[{"name":"Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M","family":"Starke","sequence":"additional","affiliation":[{"name":"Neurological Surgery, University of Miami, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro M","family":"Spiotta","sequence":"additional","affiliation":[{"name":"Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min S","family":"Park","sequence":"additional","affiliation":[{"name":"Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"2025092911245055000_14.2.111.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000258112.14918.24"},{"key":"2025092911245055000_14.2.111.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"2025092911245055000_14.2.111.3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002176"},{"key":"2025092911245055000_14.2.111.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61299-9"},{"key":"2025092911245055000_14.2.111.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61384-1"},{"key":"2025092911245055000_14.2.111.6","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1161\/STROKEAHA.119.028891","article-title":"2B, 2C, or 3: what should be the angiographic target for endovascular treatment in ischemic 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Multiple imputation for nonresponse in surveys. New York: John Wiley & Sons, Wiley Series in Probability and Statistics, 1987.","DOI":"10.1002\/9780470316696"},{"key":"2025092911245055000_14.2.111.17","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017182"},{"key":"2025092911245055000_14.2.111.18","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022031"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2020-017193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T18:25:01Z","timestamp":1759170301000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2020-017193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,16]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,1,18]]},"published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1136\/neurintsurg-2020-017193"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2020-017193","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,16]]}}}