{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:21:14Z","timestamp":1785007274070,"version":"3.55.0"},"reference-count":28,"publisher":"BMJ","issue":"3","funder":[{"name":"Scientific Research Fund of Sichuan Provincial People\u2019s Hospital","award":["2020LY05"],"award-info":[{"award-number":["2020LY05"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2021,4,3]]},"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>To investigate the prevalence of small ruptured saccular intracranial aneurysms (sIA) in a Chinese cohort and to identify factors associated with rupture status of sIAs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive patients with confirmed sIAs by DSA from January 2015 to July 2019 were included. Demographic and aneurysmal features, including maximal diameter, location, irregularity (lobulated or with blebs), and aspect ratio (AR, defined as height divided by neck width) were recorded and analyzed. Mixed effect logistic regression was used in multivariate analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We analyzed 1514 sIAs in a Chinese cohort of 1216 patients, including 651 ruptured and 863 unruptured sIAs. Median aneurysm size was 5.7\u2009mm for ruptured aneurysms, with 66.1% &lt;7\u2009mm in maximal diameter, and 40.2% measuring &lt;5\u2009mm. The median PHASES score of ruptured sIAs was 5. In multivariate analysis, male sex, hypertension, locations other than the internal carotid artery, irregularity (lobulated or with blebs), and higher AR were independently associated with rupture status (OR for irregularity, 2.88, 95% CI 2.20 to 3.77, p&lt;0.001; OR for AR, 1.12, 95% CI 1.01 to 1.24, p=0.036). However, maximal diameter was not significantly associated with rupture status (p=0.72).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this cohort, ruptured sIAs were frequently smaller than 7 mm. Shape related features, such as irregularity and higher AR, were associated with the ruptured status of sIAs, irrespective of diameter. PHASES seems to be inadequate in sIA risk stratification. Shape related parameters may be further investigated in prospective studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2021-017452","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T13:56:21Z","timestamp":1619013381000},"page":"252-256","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Shape related features of intracranial aneurysm are associated with rupture status in a large Chinese cohort"],"prefix":"10.1136","volume":"14","author":[{"given":"Yuting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9223-6640","authenticated-orcid":false,"given":"Ajay","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7798-8158","authenticated-orcid":false,"given":"Mahmud","family":"Mossa-Basha","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington School of Medicine, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington School of Medicine, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"2025092912405880000_14.3.252.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052760"},{"key":"2025092912405880000_14.3.252.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70015-8"},{"key":"2025092912405880000_14.3.252.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.08.033"},{"key":"2025092912405880000_14.3.252.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70263-1"},{"key":"2025092912405880000_14.3.252.5","doi-asserted-by":"publisher","DOI":"10.3171\/2012.3.JNS111221"},{"key":"2025092912405880000_14.3.252.6","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2016.0910.003"},{"key":"2025092912405880000_14.3.252.7","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718817227"},{"key":"2025092912405880000_14.3.252.8","unstructured":"Qinghai Huang PY , Chinese Neurosurgery Society . 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