{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:04:55Z","timestamp":1780085095192,"version":"3.54.0"},"reference-count":28,"publisher":"BMJ","issue":"10","funder":[{"name":"Discipline Climbing Scheme","award":["2019YXK023"],"award-info":[{"award-number":["2019YXK023"]}]},{"name":"Discipline Climbing Scheme","award":["2019YXK030"],"award-info":[{"award-number":["2019YXK030"]}]},{"name":"National Research and Development Project of Key Chronic Diseases","award":["2016YFC1300700"],"award-info":[{"award-number":["2016YFC1300700"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2021,10,15]]},"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate predictors of unfavorable outcome in stent-assisted coiling for symptomatic unruptured intracranial spontaneous vertebral artery dissecting aneurysms (uis-VADAs) based on 608 reconstructed lesions in 30 medical centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 608 patients (male:female=479:129; mean age, 53.26\u00b110.26 years) with 608 symptomatic uis-VADAs underwent reconstructive treatments using stent(s) with coils between January 2009 and December 2015. Treatments and predictors of unfavorable outcomes were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mainly, three methods were used to treat patients with uis-VADAs, including routine single-stent in 208 patients (such as Enterprise and others), new low-profile LVIS single stent in 107 patients, and multiple stents in 293 patients. During the median 66 months of clinical follow-up, 14 patients died, and 16 of the remaining 594 survivors had unfavorable outcomes (modified Rankin Scale score 3\u20135). The overall mortality rate was 2.3% (14\/608), and the unfavorable outcome (mRS score 3\u20136) rate was 4.9% (30\/608). Multivariate logistic regression analysis indicated that preprocedural ischemic infarctions (OR=3.78; 95% CI 1.52 to 9.40; p&lt;0.01), diabetes mellitus (OR=3.74; 95%\u2009CI 1.31 to 10.68; p=0.01), and procedural complications (OR=14.18; 95%\u2009CI 5.47 to 36.80; p&lt;0.01) were predictors of unfavorable outcome in the reconstructed VADAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This multicenter study indicated that preprocedural ischemic infarctions, diabetes mellitus, and procedural complications were related to unfavorable clinical outcomes in the reconstructed uis-VADAs.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2021-017619","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T18:32:30Z","timestamp":1636482750000},"page":"1008-1013","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Predictors of unfavorable outcome in stent-assisted 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