{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:54:23Z","timestamp":1790488463499,"version":"4.1.0"},"reference-count":17,"publisher":"BMJ","issue":"11","funder":[{"DOI":"10.13039\/501100004571","name":"Minist\u00e8re des Affaires Sociales et de la Sant\u00e9","doi-asserted-by":"publisher","award":["PHRCI-15-076"],"award-info":[{"award-number":["PHRCI-15-076"]}],"id":[{"id":"10.13039\/501100004571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2021,10,15]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Half of the patients with large vessel occlusion (LVO)-related acute ischemic stroke (AIS) who undergo endovascular reperfusion are dead or dependent at 3 months. We hypothesize that in addition to established prognostic factors, baseline imaging profile predicts outcome among reperfusers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive patients receiving endovascular treatment (EVT) within 6\u2009hours after onset with Thrombolysis In Cerebral Infarction (TICI) 2b, 2c and 3 revascularization were included. Poor outcome was defined by a modified Rankin scale (mRS) 3\u20136 at 90 days. No mismatch (NoMM) profile was defined as a mismatch (MM) ratio \u22641.2 and\/or a volume &lt;10\u2009mL on pretreatment imaging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>187 patients were included, and 81 (43%) had a poor outcome. Median delay from stroke onset to the end of EVT was 259\u2009min (IQR 209\u2013340). After multivariable logistic regression analysis, older age (OR 1.26, 95% CI 1.06 to 1.5; p=0.01), higher National Institutes of Health Stroke Scale (NIHSS) (OR 1.15, 95% CI 1.06 to 1.25; p&lt;0.0001), internal carotid artery (ICA) occlusion (OR 3.02, 95% CI 1.2 to 8.0; p=0.021), and NoMM (OR 4.87, 95% CI 1.09 to 22.8; p=0.004) were associated with poor outcome. In addition, post-EVT hemorrhage (OR 3.64, 95% CI 1.5 to 9.1; p=0.04) was also associated with poor outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The absence of a penumbra defined by a NoMM profile on baseline imaging appears to be an independent predictor of poor outcome after reperfusion. Strategies aiming to preserve the penumbra may be encouraged to improve these patients\u2019 outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2021-017946","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T13:20:54Z","timestamp":1636377654000},"page":"1051-1055","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["What predicts poor outcome after successful thrombectomy in early time window?"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-2276","authenticated-orcid":false,"given":"Jean-Marc","family":"Olivot","sequence":"first","affiliation":[{"name":"Neurology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France"},{"name":"Toulouse Neuro Imaging Center, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1055-8000","authenticated-orcid":false,"given":"Jeremy J","family":"Heit","sequence":"additional","affiliation":[{"name":"Radiology, Neuroadiology and Neurointervention Division, Stanford University, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Mazighi","sequence":"additional","affiliation":[{"name":"Fondation Ophtalmologique Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Raposo","sequence":"additional","affiliation":[{"name":"Neurology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France"},{"name":"Toulouse Neuro Imaging Center, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Fran\u00e7ois","family":"Albucher","sequence":"additional","affiliation":[{"name":"Neurology, Centre Hospitalier 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EXPRESS: temporary application of lower body positive pressure improves intracranial velocities in symptomatic acute carotid occlusion or tight stenosis: a pilot study. 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