{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:31:20Z","timestamp":1792816280921,"version":"4.5.0"},"reference-count":25,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2021,8,30]]},"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Non-ischemic cerebral enhancing (NICE) lesions are exceptionally rare following aneurysm endovascular therapy (EVT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the presenting features and longitudinal follow-up of patients with NICE lesions following aneurysm EVT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients included in a retrospective national multicentre inception cohort were analysed. NICE lesions were defined, using MRI, as delayed onset punctate, nodular or annular foci enhancements with peri-lesion edema, distributed in the vascular territory of the aneurysm EVT, with no other confounding disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From a pool of 58 815 aneurysm endovascular treatment procedures during the study sampling period (2006\u20132019), 21\/37 centres identified 31 patients with 32 aneurysms of the anterior circulation who developed NICE lesions (mean age 45\u00b110 years). Mean delay to diagnosis was 5\u00b19 months, with onset occurring a month or less after the index EVT procedure in 10 out of 31 patients (32%). NICE lesions were symptomatic at time of onset in 23 of 31 patients (74%). After a mean follow-up of 25\u00b126 months, 25 patients (81%) were asymptomatic or minimally symptomatic without disability (modified Rankin Scale (mRS) score 0\u20131) at last follow-up while 4 (13%) presented with mild disability (mRS score 2). Clinical follow-up data were unavailable for two patients. Follow-up MRI (available in 27 patients; mean time interval after onset of 22\u00b122 months) demonstrated persistent enhancement in 71% of cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The clinical spectrum of NICE lesions following aneurysm EVT therapy spans a wide range of neurological symptoms. Clinical course is most commonly benign, although persistent long-term enhancement is frequent.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2021-017992","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T13:33:00Z","timestamp":1632144780000},"page":"925-930","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Non-ischemic cerebral enhancing lesions after intracranial aneurysm endovascular repair: a retrospective French national registry"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-8431","authenticated-orcid":false,"given":"Eimad","family":"Shotar","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Antoine","family":"Labeyrie","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Lariboisi\u00e8re Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Biondi","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology and Endovascular Therapy, Besan\u00e7on University Hospital, Besancon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Velasco","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Department, Poitiers University Hospital, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-7976","authenticated-orcid":false,"given":"Guillaume","family":"Saliou","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Vaud, Switzerland"},{"name":"Faculty of Medicine, UNIL, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Boulouis","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Bretonneau Hospital, Tours, France"},{"name":"Interventional Neuroradiology Department, Sainte Anne Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Daumas-Duport","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Bourcier","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-3125","authenticated-orcid":false,"given":"Kevin","family":"Janot","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Bretonneau Hospital, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Herbreteau","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Bretonneau Hospital, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Michelozzi","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Michallon Hospital, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Premat","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hocine","family":"Redjem","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Fondation Rothschild Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1469-3613","authenticated-orcid":false,"given":"Nicolas","family":"Bricout","sequence":"additional","affiliation":[{"name":"Department of interventional Neuroradiology, Centre Hospitalier Regional Universitaire de Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Thouant","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, F Mitterand Hospital, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Arteaga","sequence":"additional","affiliation":[{"name":"H\u00f4pital d'Instruction des Arm\u00e9es Sainte-Anne Biblioth\u00e8que, Toulon, Provence-Alpes-C\u00f4te d'Azu, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6893-661X","authenticated-orcid":false,"given":"Laurent","family":"Pierot","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Reims, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Tahon","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Grenoble University Hospital, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Boubagra","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Grenoble University Hospital, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Ikka","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Kremlin Bicetre University Hospital, Kremlin Bicetre, 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