{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:46:15Z","timestamp":1780706775340,"version":"3.54.1"},"reference-count":22,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2022,1,9]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Carotid webs (CaW) are now recognized as a cause of ischemic stroke in young patients. The thromboembolic potential appears related to the CaW\u2019s morphology and consequent impact on local flow dynamics. We aim to evaluate the reliability of different measurement methods for the quantification of CaW and their relationship to symptomatic status, presence of large vessel occlusion stroke (LVOS), clot burden and final infarct volume.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective analysis of the local comprehensive stroke center CaW database (September 2014\u2013July 2019). CT angiograms (CTAs) were reviewed independently by two raters, blinded to the clinical information and laterality of the stroke\/transient ischemic attack. CaW were quantified with 1-D (length), 2-D (area) and 3-D (volume) measurements via Osirix software. Final infarct volume was calculated on MRI. Patients with superimposed CaW thrombus and no repeat imaging were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty-eight CaW (37 symptomatic and 11 contralateral\/asymptomatic) in 38 patients were included. Mean age (\u00b1SD) was 48.7 (\u00b18.5) years, 78.9% were women and 77.1% were black. Inter-rater agreement was 0.921 (p&lt;0.001) for 1-D, 0.930 (p&lt;0.001) for 2-D, and 0.937 (p&lt;0.001) for 3-D CaW measurements. When comparing symptomatic with asymptomatic CaW, mean web length was 3.2 mm versus 2.5 mm (p&lt;0.02), median area was 5.8 versus 5.0 mm<jats:sup>2<\/jats:sup> (p=0.35) and median volume was 15.0 versus 10.6 mm<jats:sup>3<\/jats:sup> (p&lt;0.04), respectively. CaW with a thinner profile (longer intraluminal projection compared with the base) were more likely to be symptomatic (0.67\u00b10.17 vs 0.88\u00b10.37; p=0.01). Average CaW 1-D and final infarct volume had a weak but positive association (\u039a=0.230, p&lt;0.05), while no association among web measurements and the presence of LVOS or clot burden was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CaW dimension quantification (1-D, 2-D and 3-D) is highly reproducible. Linear and volumetric measurements were more strongly associated with symptoms. The impact of CaW size on the presence of LVOS, clot burden and final infarct volume is unclear.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2021-018192","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T13:21:53Z","timestamp":1645017713000},"page":"153-156","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Comparative analysis between 1-D, 2-D and 3-D carotid web quantification"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9353-1219","authenticated-orcid":false,"given":"Catarina","family":"Perry da Camara","sequence":"first","affiliation":[{"name":"Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA"},{"name":"Department of Neuroradiology, Centro Hospitalar Universit\u00e1rio Lisboa Central, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul G","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-1930","authenticated-orcid":false,"given":"Alhamza R","family":"Al-Bayati","sequence":"additional","affiliation":[{"name":"Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0300-6355","authenticated-orcid":false,"given":"Leonardo","family":"Pisani","sequence":"additional","affiliation":[{"name":"Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Mohammaden","sequence":"additional","affiliation":[{"name":"Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason W","family":"Allen","sequence":"additional","affiliation":[{"name":"Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Nahab","sequence":"additional","affiliation":[{"name":"Neurology, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4637-1598","authenticated-orcid":false,"given":"Marta","family":"Olive Gadea","sequence":"additional","affiliation":[{"name":"Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA"},{"name":"Department of Neurology, Hospital Vall d'Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Frankel","sequence":"additional","affiliation":[{"name":"Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo C","family":"Haussen","sequence":"additional","affiliation":[{"name":"Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"2025092913324237000_15.2.153.1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007313"},{"key":"2025092913324237000_15.2.153.2","doi-asserted-by":"crossref","unstructured":"Coutinho JM , Derkatch S , Potvin ARJ . Carotid artery web and ischemic stroke: a case-control study. Neurology 2017.","DOI":"10.1212\/WNL.0000000000003464"},{"key":"2025092913324237000_15.2.153.3","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021907"},{"key":"2025092913324237000_15.2.153.4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/jamaneurol.2018.3366","article-title":"Current understanding and gaps in research of carotid webs in ischemic strokes: a review","volume":"76","author":"Kim","year":"2019","journal-title":"JAMA Neurol"},{"key":"2025092913324237000_15.2.153.5","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019020"},{"key":"2025092913324237000_15.2.153.6","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5946"},{"key":"2025092913324237000_15.2.153.7","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2019.00220","article-title":"Multimodality imaging in carotid web","volume":"10","author":"Madaelil","year":"2019","journal-title":"Front Neurol"},{"key":"2025092913324237000_15.2.153.8","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4431"},{"key":"2025092913324237000_15.2.153.9","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017170094"},{"key":"2025092913324237000_15.2.153.10","doi-asserted-by":"crossref","first-page":"104402","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104402","article-title":"Carotid webs in cryptogenic ischemic strokes: a matched case-control study","volume":"28","author":"Kim","year":"2019","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2025092913324237000_15.2.153.11","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2021.1101","article-title":"Assessment of recurrent stroke risk in patients with a carotid web","volume":"78","author":"Guglielmi","year":"2021","journal-title":"JAMA Neurol"},{"key":"2025092913324237000_15.2.153.12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1159\/000489710","article-title":"Multicenter experience with stenting for symptomatic carotid web","volume":"7","author":"Haussen","year":"2018","journal-title":"Interv Neurol"},{"key":"2025092913324237000_15.2.153.13","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-019-0786-4"},{"key":"2025092913324237000_15.2.153.14","first-page":"703-708","article-title":"Flow patterns in carotid webs: a patient-based computational fluid dynamics study","volume":"40","author":"Compagne","year":"2019","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025092913324237000_15.2.153.15","doi-asserted-by":"crossref","first-page":"105823","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105823","article-title":"Baseline characteristics of patients with symptomatic carotid webs: a matched case control study","volume":"30","author":"Landzberg","year":"2021","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2025092913324237000_15.2.153.16","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"2025092913324237000_15.2.153.17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2008.00221.x"},{"key":"2025092913324237000_15.2.153.18","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5208"},{"key":"2025092913324237000_15.2.153.19","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013918"},{"key":"2025092913324237000_15.2.153.20","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2017-000129"},{"key":"2025092913324237000_15.2.153.21","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6012"},{"key":"2025092913324237000_15.2.153.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00786-4"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2021-018192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:32:48Z","timestamp":1759177968000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2021-018192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,16]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1,11]]},"published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1136\/neurintsurg-2021-018192"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2021-018192","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,16]]}}}