{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:03:40Z","timestamp":1784610220761,"version":"3.55.0"},"reference-count":16,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Bendit Technologies, LTD","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2022,2,22]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Endovascular treatment of intracranial vascular diseases, such as aneurysms, is often challenged by unfavorable vascular anatomy. The Bendit Steerable Microcatheter (Bendit Technologies, Tel Aviv, Israel) has bending and torqueing capabilities designed to improve navigation and stability during device delivery, with or without a guidewire. We describe our preclinical experience with the Bendit 17 and Bendit 21 microcatheters in a rabbit aneurysm model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bifurcation and side wall aneurysms were created surgically in six New Zealand rabbits. We attempted to navigate Bendit devices through the vasculature and enter the aneurysms without a guidewire. Various positions within the aneurysm were selectively explored. Angiographic imaging was used to visualize catheterization, navigation, vascular manipulations, and placement of coils, stents, and intrasaccular devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We successfully navigated the Bendit microcatheters to all aneurysms without a guidewire. We successfully recanalized a nearly occluded carotid artery and navigated the Bendit through a braided stent. In contrast, we were unable to navigate a comparator device with a guidewire as effectively as the Bendit. Coils were introduced at different locations within the aneurysm and could be pushed, pulled, and repositioned with the Bendit tip. Finally, we used the Bendit to deliver intrasaccular devices designed for terminal aneurysms to treat side wall aneurysms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bendit\u2019s bending and torqueing abilities, combined with its stability in the bent position, enable quick navigation and optimal deployment of devices. Clinical studies are necessary to determine whether these navigation advantages lead to more efficient treatment of intracranial and peripheral aneurysms.<\/jats:p><\/jats:sec>","DOI":"10.1136\/neurintsurg-2022-018644","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T17:29:14Z","timestamp":1647365354000},"page":"172-175","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["New concept in neurovascular navigation: technical description and preclinical experience with the Bendit 17 and Bendit 21 microcatheters in a rabbit aneurysm model"],"prefix":"10.1136","volume":"15","author":[{"given":"Alejandro","family":"Berenstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oz","family":"Cabiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-2427","authenticated-orcid":false,"given":"Erasmia","family":"Broussalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Hufnagl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-7694","authenticated-orcid":false,"given":"Monika","family":"Killer-Oberpfalzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"2024052309440181000_15.2.172.1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014623"},{"key":"2024052309440181000_15.2.172.2","doi-asserted-by":"crossref","DOI":"10.1126\/scirobotics.abf0601","article-title":"Soft robotic steerable microcatheter for the endovascular treatment of cerebral disorders","volume":"6","author":"Gopesh","year":"2021","journal-title":"Sci Robot"},{"key":"2024052309440181000_15.2.172.3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/13645706.2019.1606018","article-title":"Use of a steerable triaxial system for challenging catheterization","volume":"29","author":"Shimohira","year":"2020","journal-title":"Minim Invasive Ther Allied Technol"},{"key":"2024052309440181000_15.2.172.4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/1591019918824012","article-title":"Precision microcatheter shaping in vertebrobasilar aneurysm coiling","volume":"25","author":"Namba","year":"2019","journal-title":"Interv Neuroradiol"},{"key":"2024052309440181000_15.2.172.5","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014259"},{"key":"2024052309440181000_15.2.172.6","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015346"},{"key":"2024052309440181000_15.2.172.7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1591019917689926","article-title":"Microcatheter shaping using intravascular placement during intracranial aneurysm coiling","volume":"23","author":"Yamaguchi","year":"2017","journal-title":"Interv Neuroradiol"},{"key":"2024052309440181000_15.2.172.8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s42155-019-0078-9","article-title":"Use of a steerable microcatheter during superselective angiography: impact on radiation exposure and procedural efficiency","volume":"2","author":"Hoffmann","year":"2019","journal-title":"CVIR Endovasc"},{"key":"2024052309440181000_15.2.172.9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/24699322.2018.1526972","article-title":"Steerable catheters for minimally invasive surgery: a review and future directions","volume":"23","author":"Hu","year":"2018","journal-title":"Comput Assist Surg"},{"key":"2024052309440181000_15.2.172.10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.radcr.2017.04.006","article-title":"Coil embolization of reversed-curve hepatointestinal collaterals in radioembolization: potential solutions for a challenging task","volume":"12","author":"Hinrichs","year":"2017","journal-title":"Radiol Case Rep"},{"key":"2024052309440181000_15.2.172.11","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1007\/s00270-017-1789-8","article-title":"Experiments for the development of a steerable microcatheter","volume":"40","author":"Inaba","year":"2017","journal-title":"Cardiovasc Intervent Radiol"},{"key":"2024052309440181000_15.2.172.12","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00270-017-1579-3","article-title":"The steerable microcatheter: a new device for selective catheterisation","volume":"40","author":"Soyama","year":"2017","journal-title":"Cardiovasc Intervent Radiol"},{"key":"2024052309440181000_15.2.172.13","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-012094"},{"key":"2024052309440181000_15.2.172.14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1252059"},{"key":"2024052309440181000_15.2.172.15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3171\/2016.10.JNS162024","article-title":"Physiological remodeling of bifurcation aneurysms: preclinical results of the eCLIPs device","volume":"128","author":"Marotta","year":"2018","journal-title":"J Neurosurg"},{"key":"2024052309440181000_15.2.172.16","doi-asserted-by":"crossref","DOI":"10.3791\/2718-v","article-title":"Microsurgical venous pouch arterial-bifurcation aneurysms in the rabbit model: technical aspects","author":"Sherif","year":"2011","journal-title":"J Vis Exp"}],"container-title":["Journal of NeuroInterventional Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/neurintsurg-2022-018644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T16:44:21Z","timestamp":1716482661000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnis.bmj.com\/lookup\/doi\/10.1136\/neurintsurg-2022-018644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,15]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1,11]]},"published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1136\/neurintsurg-2022-018644"],"URL":"https:\/\/doi.org\/10.1136\/neurintsurg-2022-018644","relation":{},"ISSN":["1759-8478","1759-8486"],"issn-type":[{"value":"1759-8478","type":"print"},{"value":"1759-8486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,15]]}}}