{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:58:33Z","timestamp":1785549513516,"version":"3.56.0"},"reference-count":20,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J NeuroIntervent Surg"],"accepted":{"date-parts":[[2022,4,3]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Endovascular treatment (EVT) for basilar artery occlusions (BAO) is associated with a higher rate of futile recanalization compared with anterior circulation procedures. We aimed to identify the incidence and predictors of poor clinical outcome despite successful reperfusion in current clinical practice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used data from the ETIS (Endovascular Treatment in Ischemic Stroke) registry, a prospective multicenter observational registry of stroke treated with EVT in France. Patients undergoing EVT for acute BAO from January 2014 to May 2019 successfully treated within 8\u2009hours from onset were included. Predictors of 90-day poor outcome (modified Rankin Scale (mRS) 4\u20136) were researched within patients with successful (modified Thrombolysis In Cerebral Infarction (mTICI 2b-3)) and excellent (mTICI 2c-3) reperfusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 242 patients treated within 8\u2009hours, successful reperfusion was achieved in 195 (80.5%) and excellent reperfusion in 120 (49.5%). Poor outcome was observed in 107 (54.8%) and 60 (50%) patients, respectively. In patients with successful early reperfusion, age, higher initial National Institutes of Health Stroke Scale (NIHSS) score, lower posterior circulation Alberta Stroke Programme Early CT Score (pc-ASPECTS), and absence of prior intravenous thrombolysis were independent predictors of poor outcome. The only treatment factor with an independent predictive value was first-pass mTICI 2b-3 reperfusion (adjusted OR 0.13, 95%\u2009CI 0.05 to 0.37, p&lt;0.001). In patients with excellent early reperfusion, independent predictors were age, initial NIHSS score, first-pass mTICI 2c-3 reperfusion, and hemorrhagic transformation on post-interventional imaging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Early successful reperfusion with EVT occurred in 80.5% of patients, and the only treatment-related factor predictive of clinical outcome was first pass mTICI 2b-3 reperfusion. Further research is warranted to identify the optimal techniques and devices associated with first pass reperfusion in the posterior circulation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/neurintsurg-2022-018769","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T13:25:26Z","timestamp":1650029126000},"page":"415-421","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Poor clinical outcome despite successful basilar occlusion recanalization in the early time window: incidence and predictors"],"prefix":"10.1136","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct03776877","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct03776877","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-1496","authenticated-orcid":false,"given":"Raoul","family":"Pop","sequence":"first","affiliation":[{"name":"Interventional Neuroradiology, University Hospitals Strasbourg, Strasbourg, France"},{"name":"Interventional Radiology, Institut de Chirurgie Guid\u00e9e par l'Image, Strasbourg, France"},{"name":"University of Strasbourg, INSERM UMR-S1255, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2140-7881","authenticated-orcid":false,"given":"Stephanos Nikolaos","family":"Finitsis","sequence":"additional","affiliation":[{"name":"Radiology, University General Hospital of Thessaloniki AHEPA, Thessaloniki, Central Macedonia, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Arquizan","sequence":"additional","affiliation":[{"name":"Neurology, H\u00f4pital Gui de Chauliac, Montpellier, Languedoc-Roussillon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Elhorany","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology, Hopital Universitaire Pitie Salpetriere, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Naggara","sequence":"additional","affiliation":[{"name":"Radiology, Saint Anne Hospital Centre, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Darcourt","sequence":"additional","affiliation":[{"name":"Radiology, H\u00f4pital Purpan, Toulouse, Midi-Pyr\u00e9n\u00e9es, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Claren\u00e7on","sequence":"additional","affiliation":[{"name":"Sorbonne Universite, Paris, \u00cele-de-France, France"},{"name":"Neuroradiology, Hopital Universitaire Pitie Salpetriere, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0945-5656","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Richard","sequence":"additional","affiliation":[{"name":"Neurology Stroke Unit, University Hospital Centre Nancy, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-7753","authenticated-orcid":false,"given":"Gaultier","family":"Marnat","sequence":"additional","affiliation":[{"name":"Interventional and Diagnostic Neuroradiology, University Hospital Centre Bordeaux, Bordeaux, Aquitaine, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Bourcier","sequence":"additional","affiliation":[{"name":"Neuroradiology, Universit\u00e9 de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Sibon","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Dargazanli","sequence":"additional","affiliation":[{"name":"Neuroradiology, Centre Hospitalier Regional Universitaire de Montpellier, Montpellier, Languedoc-Roussillon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3975-3865","authenticated-orcid":false,"given":"Rapha\u00ebl","family":"Blanc","sequence":"additional","affiliation":[{"name":"Departement of interventional neuroradiology, Fondation Rothschild, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Lapergue","sequence":"additional","affiliation":[{"name":"Neurology, Hopital Foch, Suresnes, \u00cele-de-France, France"},{"name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines, Versailles, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-8541","authenticated-orcid":false,"given":"Arturo","family":"Consoli","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Neuroradiology, Hospital Foch, Suresnes, France"},{"name":"Interventional Neurovascular Unit, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7367-8793","authenticated-orcid":false,"given":"Francois","family":"Eugene","sequence":"additional","affiliation":[{"name":"Radiologie, CHU Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Vannier","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU Rennes, Rennes, Bretagne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0029-1835","authenticated-orcid":false,"given":"Jildaz","family":"Caroff","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology - NEURI Brain Vascular Center, Bic\u00eatre Hospital, APHP, Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Denier","sequence":"additional","affiliation":[{"name":"Neurology, Hopital Bicetre, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Boulanger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Universitaire de Caen, Caen, Basse-Normandie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Gauberti","sequence":"additional","affiliation":[{"name":"Neuroradiology, Centre Hospitalier Universitaire de Caen, Caen, Basse-Normandie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-3375","authenticated-orcid":false,"given":"Aymeric","family":"Rouchaud","sequence":"additional","affiliation":[{"name":"Interventional neuroradiology, Centre Hospitalier Universitaire de Limoges, Limoges, France"},{"name":"CNRS, XLIM, UMR 7252, Limoges University, Limoges, Nouvelle-Aquitaine, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Macian","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Universitaire de Limoges, Limoges, Limousin, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Rosso","sequence":"additional","affiliation":[{"name":"Urgences c\u00e9r\u00e9bro-vasculaires, Hopital Universitaire Pitie Salpetriere, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-4095","authenticated-orcid":false,"given":"Guillaume","family":"Turc","sequence":"additional","affiliation":[{"name":"Neurology, Groupe Hospitalier Universitaire Paris psychiatrie & neurosciences, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Ozkul-Wermester","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Centre Rouen, Rouen, Normandie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Fran\u00e7ois","family":"Albucher","sequence":"additional","affiliation":[{"name":"Neurology, University Hospital Centre Toulouse, Toulouse, Midi-Pyr\u00e9n\u00e9es, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-3894","authenticated-orcid":false,"given":"Anthony","family":"Le Bras","sequence":"additional","affiliation":[{"name":"Department of Radiology, Centre Hospitalier Bretagne Atlantique, Vannes, Bretagne, France"},{"name":"CHU Rennes Service de radiologie et d'imagerie m\u00e9dicale, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Evain","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Bretagne Atlantique, Vannes, Bretagne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Wolff","sequence":"additional","affiliation":[{"name":"Neurology, University Hospitals Strasbourg, Strasbourg, Alsace, 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occlusion","volume":"28","author":"Abdelrady","year":"2022","journal-title":"J Neurointerv Surg"},{"key":"2025092911145482000_15.5.415.18","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/neuros\/nyaa179","article-title":"Thrombectomy technique predicts outcome in posterior circulation stroke\u2014Insights from the STAR collaboration","volume":"87","author":"Alawieh","year":"2020","journal-title":"Neurosurgery"},{"key":"2025092911145482000_15.5.415.19","doi-asserted-by":"crossref","unstructured":"Ravindren J , Aguilar P\u00e9rez M , Hellstern V , et al . Predictors of outcome after endovascular thrombectomy in acute basilar artery occlusion and the 6hr time window to recanalization. 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