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Bearing in mind that the non-antigenic histamine-releasing agents are rather inactive in producing bronchospasm, that other signs of histamine-release are not seen in byssinosis, and that an antihistamine does not relieve the symptoms of byssinosis when given to cotton workers, we have concluded that this action can hardly be supposed to contribute to the clinical picture. The nature of the histamine-releasing factor is obscure, although our finding that it can be extracted with acetone suggests that it is a fatty, perhaps somewhat surfaceactive, material. Histamine-releasing activity and surface-activity are sometimes associated","year":"1957","unstructured":"quite close to our estimate based on rat experiments (Table 4), giving a potency ratio of the order of 10,000. Bearing in mind that the non-antigenic histamine-releasing agents are rather inactive in producing bronchospasm, that other signs of histamine-release are not seen in byssinosis, and that an antihistamine does not relieve the symptoms of byssinosis when given to cotton workers, we have concluded that this action can hardly be supposed to contribute to the clinical picture. The nature of the histamine-releasing factor is obscure, although our finding that it can be extracted with acetone suggests that it is a fatty, perhaps somewhat surfaceactive, material. Histamine-releasing activity and surface-activity are sometimes associated (Paton, 1957b)."},{"key":"ref_5","first-page":"303","volume":"9","author":"Cayton, H.R.; Furness, G.; Jackson, D.S.; Maitland, H.B.","year":"1952","unstructured":"Cayton, H. R., Furness, G., Jackson, D. S., and Maitland, H. B. (1952). Brit. J. industr. Med., 9, 303.","journal-title":"Brit. J. industr. 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[Home Office.] H.M.S.O., London."},{"key":"ref_16","first-page":"\"35P.\" # \"269.\"","volume":"137","author":"Paton, W.D.M.","year":"1957","unstructured":"Paton, W. D. M. (1957a). J. Physiol. (Lond.), 137, 35P. (1957b). Pharmacol. Rev., 9, 269.","journal-title":"J. Physiol. (Lond.)"},{"key":"ref_17","volume":"212","author":"Prausnitz, C.","year":"1936","unstructured":"Prausnitz, C. (1936). Spec. Rep. Ser. med. Res. Coun. (Lond.), No. 212.","journal-title":"Spec. Rep. Ser. med. Res. Coun. (Lond.)"},{"key":"ref_18","first-page":"1","volume":"17","author":"Roach, S.A.; Schilling, R.S.F.","year":"1960","unstructured":"Roach, S. A., and Schilling, R. S. F. (1960). Brit. J. industr. Med. 17, 1. Rocha e Silva, M., Beraldo, W. T., and Rosenfeld, G. (1949). Amer. J. Physiol., 156, 261.","journal-title":"Brit. J. industr. 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