{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T22:13:37Z","timestamp":1785104017021,"version":"3.55.0"},"reference-count":25,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Evidence from toxicological studies indicates that the risk of respiratory diseases varies with asbestos fibre length and width. However, there is a total lack of epidemiological evidence concerning this question.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Data were obtained from a cohort mortality study of 3072 workers from an asbestos textile plant which was recently updated for vital status through 2001. A previously developed job exposure matrix based on phase contrast microscopy (PCM) was modified to provide fibre size-specific exposure estimates using data from a re-analysis of samples by transmission electron microscopy (TEM). Cox proportional hazards models were fit using alternative exposure metrics for single and multiple combinations of fibre length and diameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>TEM-based cumulative exposure estimates were found to provide stronger predictions of asbestosis and lung cancer mortality than PCM-based estimates. Cumulative exposures based on individual fibre size-specific categories were all found to be highly statistically significant predictors of lung cancer and asbestosis. Both lung cancer and asbestosis were most strongly associated with exposure to thin fibres (&lt;0.25 \u03bcm). Longer (&gt;10 \u03bcm) fibres were found to be the strongest predictors of lung cancer, but an inconsistent pattern with fibre length was observed for asbestosis. Cumulative exposures were highly correlated across all fibre size categories in this cohort (0.28\u20130.99, p values &lt;0.001), which complicates the interpretation of the study findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Asbestos fibre dimension appears to be an important determinant of respiratory disease risk. Current PCM-based methods may underestimate asbestos exposures to the thinnest fibres, which were the strongest predictor of lung cancer or asbestosis mortality in this study. Additional studies are needed of other asbestos cohorts to further elucidate the role of fibre dimension and type.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oem.2007.035584","type":"journal-article","created":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T01:59:34Z","timestamp":1198202374000},"page":"613-619","source":"Crossref","is-referenced-by-count":81,"title":["An epidemiological study of the role of chrysotile asbestos fibre dimensions in determining respiratory disease risk in exposed workers"],"prefix":"10.1136","volume":"65","author":[{"given":"L","family":"Stayner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Kuempel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Dement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,12,20]]},"reference":[{"key":"2024052223445812000_65.9.613.1","first-page":"965","article-title":"Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals.","volume":"67","author":"Stanton","year":"1981","journal-title":"J Natl Cancer Inst"},{"issue":"(5)","key":"2024052223445812000_65.9.613.2","first-page":"717","article-title":"Comparisons of the pathogenicity of long and short fibres of chrysotile asbestos in rats.","volume":"69","author":"Davis","year":"1988","journal-title":"Br J Exp Pathol"},{"key":"2024052223445812000_65.9.613.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1539-6924.1995.tb00312.x"},{"key":"2024052223445812000_65.9.613.4","unstructured":"NIOSH. Asbestos and other fibers by PCM. Method 7400, Issue 2. In: NIOSH manual of analytical methods, 4th edn. DHHS (NIOSH) Publication No. 2003-154. Cincinnati, OH: National Institute for Occupational Safety and Health, 1994."},{"key":"2024052223445812000_65.9.613.5","unstructured":"Dement JM . Estimation of dose and evaluation of dose\u2013response in a retrospective cohort mortality study of chrysotile asbestos textile workers. Doctoral dissertation. North Carolina: University of North Carolina at Chapel Hill, 1980."},{"key":"2024052223445812000_65.9.613.6","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/26.8.869"},{"key":"2024052223445812000_65.9.613.7","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700040303"},{"issue":"(4)","key":"2024052223445812000_65.9.613.8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/ajim.4700260402","article-title":"Follow-up study of chrysotile asbestos textile workers: cohort mortality and case-control analyses.","volume":"26","author":"Dement","year":"1994","journal-title":"Am J Ind Med"},{"issue":"(8)","key":"2024052223445812000_65.9.613.9","first-page":"882","article-title":"Mortality patterns among female and male chrysotile asbestos textile workers.","volume":"36","author":"Brown","year":"1994","journal-title":"J Occup Med"},{"key":"2024052223445812000_65.9.613.10","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2006.031005"},{"key":"2024052223445812000_65.9.613.11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320310041026"},{"key":"2024052223445812000_65.9.613.12","doi-asserted-by":"crossref","unstructured":"Dement JM Kuempel E Gilbert S . Development of an airborne fiber size specific job-exposure. Occup Environ Med;65:605\u201312.","DOI":"10.1136\/oem.2007.033712"},{"key":"2024052223445812000_65.9.613.13","unstructured":"ISO. Ambient air \u2013 determination of asbestos fibres \u2013 direct-transfer electron microscopy method. ISO 10312. Geneva, Switzerland: International Standards Organization, 1995."},{"key":"2024052223445812000_65.9.613.14","first-page":"103","article-title":"Biologically-based indices of fiber exposure for use in epidemiology.","volume":"3","author":"Quinn","year":"1996","journal-title":"Occup Hyg"},{"key":"2024052223445812000_65.9.613.15","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0274(200008)38:2<132::AID-AJIM3>3.0.CO;2-P"},{"key":"2024052223445812000_65.9.613.16","doi-asserted-by":"publisher","DOI":"10.1080\/15459620590898108"},{"key":"2024052223445812000_65.9.613.17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables.","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Assoc Series B"},{"key":"2024052223445812000_65.9.613.18","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9088311"},{"issue":"(1)","key":"2024052223445812000_65.9.613.19","first-page":"1","article-title":"Fiber as a carcinogenic agent [in German].","volume":"184","author":"Pott","year":"1987","journal-title":"Zentralbl Bakteriol Mikrobiol Hyg [B]"},{"key":"2024052223445812000_65.9.613.20","first-page":"11","article-title":"Dust exposure and mortality in chrysotile mining, 1910\u201375.","volume":"37","author":"McDonald","year":"1980","journal-title":"Br J Ind Med"},{"key":"2024052223445812000_65.9.613.21","doi-asserted-by":"publisher","DOI":"10.1136\/oem.54.9.646"},{"issue":"(6)","key":"2024052223445812000_65.9.613.22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/0002889758507271","article-title":"Physical parameters of airborne asbestos fibres in various work environments\u2013preliminary findings.","volume":"36","author":"Gibbs","year":"1975","journal-title":"Am Ind Hyg Assoc J"},{"key":"2024052223445812000_65.9.613.23","unstructured":"Gibbs GW Hwang CY . Dimensions of airborne asbestos fibres. In: Wagner JC , ed. Biological effects of mineral fibers. Lyon, France: IARC Scientific Publications, 1980:69\u201378."},{"key":"2024052223445812000_65.9.613.24","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyh151"},{"key":"2024052223445812000_65.9.613.25","doi-asserted-by":"publisher","DOI":"10.1136\/oem.55.10.651"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oem.2007.035584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T08:14:02Z","timestamp":1716452042000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oem.2007.035584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,20]]},"references-count":25,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2008,8,29]]},"published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1136\/oem.2007.035584"],"URL":"https:\/\/doi.org\/10.1136\/oem.2007.035584","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,20]]}}}