{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:56:30Z","timestamp":1790621790654,"version":"4.1.0"},"reference-count":47,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether exposures in the workplace to organic solvents and to other agents, such as polycyclic aromatic hydrocarbons, are associated with increased risks of developing postmenopausal breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 1996 and 1997 a case\u2013control study was conducted in Montreal, Quebec. Cases comprised 556 women, aged 50\u201375\u2005years, with incident malignant breast cancer, and their controls were 613 women with other cancers, frequency matched for age, date of diagnosis and hospital. An expert team of chemists and industrial hygienists translated their job histories into exposure to about 300 agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Odds ratios (ORs) were increased for the usual risk factors for breast cancer and, adjusting for these, risks increased with occupational exposure to several agents, and were highest for exposures occurring before age 36\u2005years. Increased ORs were found for each 10-year increment in duration of exposure, before age 36\u2005years (OR<jats:sub>&lt;36<\/jats:sub>), to acrylic fibres (OR<jats:sub>&lt;36<\/jats:sub>=7.69) and to nylon fibres (OR<jats:sub>&lt;36<\/jats:sub>=1.99). For oestrogen-positive and progesterone-negative tumours, the OR doubled or more for each 10-year increase in exposure to monoaromatic hydrocarbons, and to acrylic and rayon fibres. The OR<jats:sub>&lt;36<\/jats:sub>also doubled for exposure to organic solvents that metabolise into reactive oxygen species, and to acrylic fibres. A threefold increase was found for oestrogen- and progesterone-positive tumours, with exposure to polycyclic aromatic hydrocarbons from petroleum sources.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Certain occupational exposures appear to increase the risk of developing postmenopausal breast cancer, although some findings might be due to chance or to undetected bias. Our findings are consistent with the hypothesis that breast tissue is more sensitive to adverse effects if exposure occurs when breast cells are still proliferating. More refined analyses, adjusting for hormonal receptor subtypes and studies focusing on certain chemical exposures are required to further our understanding of the role of chemicals in the development of breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oem.2009.049817","type":"journal-article","created":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T11:29:26Z","timestamp":1270121366000},"page":"263-269","source":"Crossref","is-referenced-by-count":65,"title":["Postmenopausal breast cancer and occupational exposures"],"prefix":"10.1136","volume":"67","author":[{"given":"France","family":"Labr\u00e8che","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-France","family":"Valois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Nadon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"2024052300222381000_67.4.263.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1075-122X.2006.00205.x"},{"key":"2024052300222381000_67.4.263.2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm059"},{"key":"2024052300222381000_67.4.263.3","unstructured":"Canadian Cancer Society\/National Cancer Institute of Canada. Canadian Cancer Statistics 2008. Toronto, Canada: Canadian Cancer Society, National Cancer Institute of Canada, Statistics Canada, Provincial\/Territorial Cancer Registries, Public Health Agency of Canada, 2008:11\u201312, 24\u20135. 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