{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:33:23Z","timestamp":1792794803549,"version":"4.5.0"},"reference-count":39,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2010,6,3]]},"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate changes in blood pressure, blood lipids, blood sugar and haematological markers of inflammation associated with changes in long-term exposure to ambient air pollutants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted secondary analyses of data on blood pressure and blood biochemistry markers from the Social Environment and Biomarkers of Aging Study in Taiwan and air pollution data from the Taiwan Environmental Protection Administration in 2000. Associations of 1-year averaged criteria air pollutants (particulate matter with aerodynamic diameters &lt;10\u2005\u03bcm (PM<jats:sub>10<\/jats:sub>) and &lt;2.5\u2005\u03bcm (PM<jats:sub>2.5<\/jats:sub>), ozone (O<jats:sub>3<\/jats:sub>), nitrogen dioxide (NO<jats:sub>2<\/jats:sub>), sulfur dioxide and carbon monoxide) with systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol, fasting glucose, haemoglobin A1c (HbA1c), interleukin 6 (IL-6) and neutrophils were explored by applying generalised additive models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After controlling for potential confounders, we observed that increased 1-year averaged particulate air pollutants (PM<jats:sub>10<\/jats:sub>and PM<jats:sub>2.5<\/jats:sub>) and NO<jats:sub>2<\/jats:sub>were associated with elevated blood pressure, total cholesterol, fasting glucose, HbA1c, IL-6 and neutrophils. Associations of increased 1-year averaged O<jats:sub>3<\/jats:sub>with elevated blood pressure, total cholesterol, fasting glucose, HbA1c and neutrophils were also observed. In particular, our two-pollutant models showed that PM<jats:sub>2.5<\/jats:sub>was more significantly associated with end-point variables than two gaseous pollutants, O<jats:sub>3<\/jats:sub>and NO<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Changes in blood pressure, blood lipids, blood sugar and haematological markers of inflammation are associated with long-term exposure to ambient air pollutants. This might provide a link between air pollution and atherosclerotic cardiovascular diseases.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oem.2009.052704","type":"journal-article","created":{"date-parts":[[2010,9,11]],"date-time":"2010-09-11T02:20:40Z","timestamp":1284171640000},"page":"64-68","source":"Crossref","is-referenced-by-count":273,"title":["Long-term air pollution exposure and risk factors for cardiovascular diseases among the elderly in Taiwan"],"prefix":"10.1136","volume":"68","author":[{"given":"Kai-Jen","family":"Chuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Horng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Yi","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsun-Jen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,9,10]]},"reference":[{"key":"2024052300281186000_68.1.64.1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1515\/REVEH.2007.22.2.115","article-title":"Is air pollution a cause of cardiovascular disease? Updated review and controversies","volume":"22","author":"Brook","year":"2007","journal-title":"Rev Environ Health"},{"key":"2024052300281186000_68.1.64.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/151.3_Pt_1.669"},{"key":"2024052300281186000_68.1.64.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.9.1132"},{"key":"2024052300281186000_68.1.64.4","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9201"},{"key":"2024052300281186000_68.1.64.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000108927.80044.7F"},{"key":"2024052300281186000_68.1.64.6","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10565"},{"key":"2024052300281186000_68.1.64.7","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800362"},{"key":"2024052300281186000_68.1.64.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000128587.30041.C8"},{"key":"2024052300281186000_68.1.64.9","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318190ea3f"},{"key":"2024052300281186000_68.1.64.10","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj186"},{"key":"2024052300281186000_68.1.64.11","unstructured":"Taiwan Provincial Institute of Family Planning. Population Studies Center and Institute of Gerontology, University of Michigan. 1989 survey of health and living status of the elderly in Taiwan: questionnaire and survey design. Comparative study of the elderly in four Asia countries, research report No. 1. Ann Arbor, MI: Population Studies Center, University of Michigan, 1989."},{"key":"2024052300281186000_68.1.64.12","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.3.B201"},{"key":"2024052300281186000_68.1.64.13","unstructured":"Hastie TJ Tibshirani RJ . Generalized additive models. Chapman & Hall\/CRC Monographs on Statistics & Applied Probability, Vol. 43. London: Chapman and Hall\/CRC, 1989."},{"key":"2024052300281186000_68.1.64.14","doi-asserted-by":"publisher","DOI":"10.2307\/3315405"},{"key":"2024052300281186000_68.1.64.15","unstructured":"R Development Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2008."},{"key":"2024052300281186000_68.1.64.16","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90203-2"},{"key":"2024052300281186000_68.1.64.17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"2024052300281186000_68.1.64.18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000136809.55141.3B"},{"key":"2024052300281186000_68.1.64.19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480090101035"},{"key":"2024052300281186000_68.1.64.20","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.8.758"},{"key":"2024052300281186000_68.1.64.21","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.5.500"},{"key":"2024052300281186000_68.1.64.22","doi-asserted-by":"publisher","DOI":"10.1253\/circj.72.867"},{"key":"2024052300281186000_68.1.64.23","doi-asserted-by":"publisher","DOI":"10.2307\/3434788"},{"key":"2024052300281186000_68.1.64.24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jea.7500408"},{"key":"2024052300281186000_68.1.64.25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.15.1767"},{"key":"2024052300281186000_68.1.64.26","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.17.2107"},{"key":"2024052300281186000_68.1.64.27","first-page":"33","article-title":"Clinical aspects of assessment of endothelial function","volume":"58","author":"Kasprzak","year":"2006","journal-title":"Pharmacol Rep"},{"key":"2024052300281186000_68.1.64.28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/10473289.1999.10463890","article-title":"Day-to-day particulate exposures and health changes in Los Angeles area residents with severe lung disease","volume":"49","author":"Linn","year":"1999","journal-title":"J Air Waste Manag Assoc"},{"key":"2024052300281186000_68.1.64.29","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7785"},{"key":"2024052300281186000_68.1.64.30","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.116-a486"},{"key":"2024052300281186000_68.1.64.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61778-4"},{"key":"2024052300281186000_68.1.64.32","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9499"},{"key":"2024052300281186000_68.1.64.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01715-1"},{"key":"2024052300281186000_68.1.64.34","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.23.3003"},{"key":"2024052300281186000_68.1.64.35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/153537020422900411","article-title":"Nitrogen dioxide air pollution near ambient levels is an atherogenic risk primarily in obese subjects: a brief communication","volume":"229","author":"Takano","year":"2004","journal-title":"Exp Biol Med (Maywood)"},{"key":"2024052300281186000_68.1.64.36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.1999.00169.x"},{"issue":"Suppl 2","key":"2024052300281186000_68.1.64.37","first-page":"S35","article-title":"Mechanism by which hyperglycemia plays a role in the setting of acute cardiovascular illness","volume":"7","author":"Zarich","year":"2006","journal-title":"Rev Cardiovasc Med"},{"key":"2024052300281186000_68.1.64.38","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093661.90582.c4"},{"key":"2024052300281186000_68.1.64.39","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108419"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oem.2009.052704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T09:08:00Z","timestamp":1716455280000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oem.2009.052704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,10]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,12,10]]},"published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1136\/oem.2009.052704"],"URL":"https:\/\/doi.org\/10.1136\/oem.2009.052704","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,10]]}}}