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On the basis of limited human evidence and sufficient evidence in experimental animals, in 2007 the International Agency for Research on Cancer (IARC) classified \u2018shift work that involves circadian disruption\u2019 as a probable human carcinogen, group 2A. A limitation of the epidemiological studies carried out to date is in the definition of \u2018shift work.\u2019 IARC convened a workshop in April 2009 to consider how \u2018shift work\u2019 should be assessed and what domains of occupational history need to be quantified for more valid studies of shift work and cancer in the future. The working group identified several major domains of non-day shifts and shift schedules that should be captured in future studies: (1) shift system (start time of shift, number of hours per day, rotating or permanent, speed and direction of a rotating system, regular or irregular); (2) years on a particular non-day shift schedule (and cumulative exposure to the shift system over the subject's working life); and (3) shift intensity (time off between successive work days on the shift schedule). The group also recognised that for further domains to be identified, more research needs to be conducted on the impact of various shift schedules and routines on physiological and circadian rhythms of workers in real-world environments.<\/jats:p>","DOI":"10.1136\/oem.2009.053512","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T02:08:52Z","timestamp":1287626932000},"page":"154-162","source":"Crossref","is-referenced-by-count":339,"title":["Considerations of circadian impact for defining \u2018shift work\u2019 in cancer studies: IARC Working Group Report"],"prefix":"10.1136","volume":"68","author":[{"given":"Richard 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