{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:40:04Z","timestamp":1790361604010,"version":"4.1.0"},"reference-count":45,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2010,9,27]]},"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Chronic beryllium disease (CBD) is a hypersensitivity granulomatous pulmonary disease caused by exposure to the metal beryllium (Be\n                      <jats:sup>2+<\/jats:sup>\n                      ). Our objective was to extend current knowledge of the genetics of beryllium disease by examining all HLA-DPB1 and HLA-DPR1 gene polymorphisms and the interactions between them.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>DNA-based typing of HLA-DPB1 and HLA-DRB1 loci at the allele level was performed on 65 CBD, 44 beryllium sensitised (BeS) but without CBD and 288 non-affected, beryllium exposed controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The DP\u03b2E69 residue regardless of zygosity, but particularly if present on non-*0201 alleles, was of primary importance for the development of CBD and BeS, while other negatively charged residues DP\u03b2DE55, 56 and DP\u03b2DE84, 85 incrementally increased, although not independently, the risk. The DP\u03b2E69 positive alleles with charge \u22127 or \u22129 were associated with both CBD and BeS. The polymorphic residues DP\u03b2E69, DP\u03b2DE55, 56 and DP\u03b2DE84, 85 were responsible for the \u22129 charge and the first two residues for the \u22127 charge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In the absence of DP\u03b2E69, DR\u03b2E71 is a risk factor for CBD and BeS. DP\u03b2E69 and DR\u03b2E71 are adjacent to other amino acids that are also negatively charged, suggesting that the positively charged Be\n                      <jats:sup>2+<\/jats:sup>\n                      modifies the local environment of the epitopes in a way that promotes interactions between peptides and T cells and results in CBD. Finally, the protective effect of the DPB1*0201 positive haplotype may involve particular polymorphisms outside of the DPB1 gene.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/oem.2010.055046","type":"journal-article","created":{"date-parts":[[2010,12,24]],"date-time":"2010-12-24T20:35:50Z","timestamp":1293222950000},"page":"487-493","source":"Crossref","is-referenced-by-count":35,"title":["HLA class II DPB1 and DRB1 polymorphisms associated with genetic susceptibility to beryllium toxicity"],"prefix":"10.1136","volume":"68","author":[{"given":"K D","family":"Rosenman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Hertzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Kanterakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Monos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,12,23]]},"reference":[{"key":"2024052300322654000_68.7.487.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-190OC"},{"key":"2024052300322654000_68.7.487.2","first-page":"123","article-title":"Epidemiology of beryllium intoxication","volume":"4","author":"Sterner","year":"1951","journal-title":"Arch Ind Hyg Occup Med"},{"key":"2024052300322654000_68.7.487.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.8105536"},{"key":"2024052300322654000_68.7.487.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(01)00410-3"},{"key":"2024052300322654000_68.7.487.5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.6.2104002"},{"key":"2024052300322654000_68.7.487.6","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.12.6910"},{"key":"2024052300322654000_68.7.487.7","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20045"},{"key":"2024052300322654000_68.7.487.8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199710)32:4<337::AID-AJIM3>3.0.CO;2-R"},{"key":"2024052300322654000_68.7.487.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.00106201"},{"key":"2024052300322654000_68.7.487.10","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.4049\/jimmunol.163.3.1647","article-title":"Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and - DPA1 alleles","volume":"163","author":"Wang","year":"1999","journal-title":"J Immunol"},{"key":"2024052300322654000_68.7.487.11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.7029"},{"key":"2024052300322654000_68.7.487.12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.3874"},{"key":"2024052300322654000_68.7.487.13","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.5.3549"},{"key":"2024052300322654000_68.7.487.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00261-0"},{"key":"2024052300322654000_68.7.487.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.03000.x"},{"key":"2024052300322654000_68.7.487.16","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg001"},{"key":"2024052300322654000_68.7.487.17","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-94"},{"key":"2024052300322654000_68.7.487.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2007.00944.x"},{"key":"2024052300322654000_68.7.487.19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.6.4255"},{"key":"2024052300322654000_68.7.487.20","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0626-0"},{"key":"2024052300322654000_68.7.487.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.10.028"},{"key":"2024052300322654000_68.7.487.22","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e31803b9499"},{"key":"2024052300322654000_68.7.487.23","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1289\/ehp.7845","article-title":"Chronic beryllium disease and sensitization at a beryllium processing facility","volume":"113","author":"Rosenman","year":"2005","journal-title":"Environ Health Perspect"},{"key":"2024052300322654000_68.7.487.24","unstructured":"Rosenman KD Monos D Hertzberg VS . 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