{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:12:28Z","timestamp":1790197948701,"version":"4.1.0"},"reference-count":54,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2010,9,28]]},"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies show that exposure to air pollution damages human health, but the mechanisms are not fully understood. One suggested pathway is via oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study examines associations between exposure to air pollution and oxidative DNA damage, as indicated by urinary 8-hydroxy-2\u2032-deoxyguanosine (8-OHdG) concentrations in ageing participants during 2006\u20132008.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We fit linear regression models to examine associations between air pollutants and 8-OHdG adjusting for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      8-OHdG was significantly associated with ambient particulate matter \u22642.5\u2005\u03bcm in aerodynamic diameter (PM\n                      <jats:sub>2.5<\/jats:sub>\n                      ), nitrogen dioxide (NO\n                      <jats:sub>2<\/jats:sub>\n                      ), maximal 1\u2005h ozone (O\n                      <jats:sub>3<\/jats:sub>\n                      ), sulphate (SO\n                      <jats:sub>4<\/jats:sub>\n                      <jats:sup>2\u2212<\/jats:sup>\n                      ) and organic carbon (OC), but not with black carbon (BC), carbon monoxide (CO), the number of particles (PN) or elemental carbon (EC). Effects were more apparent with multi-week averages of exposures. Per IQR increases in 21-day averages of PM\n                      <jats:sub>2.5<\/jats:sub>\n                      , PN, BC, EC, OC, CO, SO\n                      <jats:sub>4<\/jats:sub>\n                      <jats:sup>2\u2212<\/jats:sup>\n                      , NO\n                      <jats:sub>2<\/jats:sub>\n                      and maximal 1\u2005h O\n                      <jats:sub>3<\/jats:sub>\n                      were associated with 30.8% (95% CI 9.3% to 52.2%), \u221213.1% (95% CI \u221241.7% to 15.5%), 3.0% (95% CI \u221219.8% to 25.8%), 5.3% (95% CI \u221223.6% to 34.2%), 24.4% (95% CI 1.8% to 47.1%), \u22122.0% (95% CI \u221212.4% to 8.3%), 29.8% (95% CI 6.3% to 53.3%), 32.2% (95% CI 7.4% to 56.9%) and 47.7% (95% CI 3.6% to 91.7%) changes in 8-OHdG, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that ageing participants experienced an increased risk of developing oxidative DNA injury after exposure to secondary, but not primary, ambient pollutants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/oem.2010.056358","type":"journal-article","created":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T23:10:07Z","timestamp":1288221007000},"page":"562-569","source":"Crossref","is-referenced-by-count":60,"title":["Urinary 8-hydroxy-2\u2032-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study"],"prefix":"10.1136","volume":"68","author":[{"given":"Cizao","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shona","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert 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