{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:32:38Z","timestamp":1774125158275,"version":"3.50.1"},"reference-count":30,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:p>OBJECTIVE--The aim was to determine the prevalence of persistent respiratory symptoms and bronchial hyper-responsiveness due to reactive airways dysfunction syndrome in a population of construction workers at moderate to high risk of developing the syndrome, at an interval of 18 to 24 months after multiple exposures to chlorine gas during renovations to a pulp and paper mill. DESIGN AND PARTICIPANTS--71 of 289 exposed workers (25%) were identified on the basis of an exposure and the onset of respiratory symptoms shortly after this event (moderate to high risk). A standardised respiratory questionnaire was first presented, followed by spirometry and a methacholine inhalation test on those whose questionnaire suggested the persistence of respiratory symptoms. RESULTS--64 of 71 (90%) subjects completed the respiratory questionnaire at the time of the follow up. The questionnaire suggested a persistence of respiratory symptoms in 58 of the 64 workers (91%). Of the 58 subjects, 51 underwent spirometry and assessment of bronchial responsiveness. All of them used bronchodilators as required (not regularly) and four required inhaled anti-inflammatory preparations. Sixteen had bronchial obstruction (forced expiratory volume in one second) (FEV1 &lt; 80% predicted) and 29 showed significant bronchial hyper-responsiveness. CONCLUSION--Of the subjects (n = 71) who were at moderate to high risk of developing reactive airways dysfunction syndrome after being exposed to chlorine and were seen 18 to 24 months after exposure ended, 58 (82%) still had respiratory symptoms, 16 (23%) had evidence of bronchial obstruction, and 29 (41%) had bronchial hyper-responsiveness.<\/jats:p>","DOI":"10.1136\/oem.51.4.225","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T00:14:48Z","timestamp":1229472888000},"page":"225-228","source":"Crossref","is-referenced-by-count":59,"title":["Survey of construction workers repeatedly exposed to chlorine over a three to six month period in a pulpmill: II. Follow up of affected workers by questionnaire, spirometry, and assessment of bronchial responsiveness 18 to 24 months after exposure ended."],"prefix":"10.1136","volume":"51","author":[{"given":"L","family":"Bh\u00e9rer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Cushman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Courteau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Qu\u00e9villon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Bourbeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"L'Archev\u00eaque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Cartier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Malo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,4,1]]},"reference":[{"key":"ref_1","first-page":"26","article-title":"Prevalence of chronic respiratory disease in a pulp mill and a paper mill in the United States","volume":"24","author":"Ferris, B.G.; Burgess, W.A.; Worcester, J.","year":"1967","unstructured":"Ferris BG, Burgess WA, Worcester J. Prevalence of chronic respiratory disease in a pulp mill and a paper mill in the United States. BrJIInd Med 1967;24:26-37.","journal-title":"BrJIInd Med"},{"key":"ref_2","first-page":"127","article-title":"Mortality and morbidity in a pulp and a paper mill in the United States: a ten year follow up","volume":"36","author":"Ferris, B.G.; Puleo, S.; Chen, H.Y.","year":"1979","unstructured":"Ferris BG, Puleo S, Chen HY. Mortality and morbidity in a pulp and a paper mill in the United States: a ten year follow up. BrJtInd Med 1979;36:127-34.","journal-title":"BrJtInd Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1378\/chest.88.3.376","article-title":"Reactive airways dysfunction syndrome (RADS). Persistent asthma syndrome after high level irritant exposures","volume":"88","author":"Brooks, S.M.; Weiss, M.A.; Bernstein, I.L.","year":"1985","unstructured":"Brooks SM, Weiss MA, Bernstein IL. Reactive airways dysfunction syndrome (RADS). 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J Allergy Clin Immunol (in press).","journal-title":"J Allergy Clin Immunol"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oem.51.4.225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T13:39:18Z","timestamp":1716471558000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oem.51.4.225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1994,4,1]]},"published-print":{"date-parts":[[1994,4]]}},"alternative-id":["10.1136\/oem.51.4.225"],"URL":"https:\/\/doi.org\/10.1136\/oem.51.4.225","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}