{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:05:23Z","timestamp":1762160723175},"reference-count":12,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:p>OBJECTIVE--The purpose of this study was to evaluate the risk of spontaneous abortion among the wives of male workers occupationally exposed to benzene. METHODS--The wives of 823 men working in two chemical plants at the time of the study were asked to complete a questionnaire describing their pregnancies. The analysis of the 1739 pregnancies that ended in a spontaneous abortion or a birth is presented. The firms' payroll records provided all workers' employment history, including dates. Benzene exposure, graded at two levels (&lt; 5, &gt; or = 5 ppm), was determined for every job, so that benzene exposure for each worker's entire professional life (at these companies) could be assessed. This information was linked to the dates of the pregnancies reported in the questionnaires to enable the exposure status of each pregnancy to be defined (1270 non-exposed and 274 exposed). The frequency of spontaneous abortion, defined as the number of spontaneous abortions divided by the total of spontaneous abortions and births was evaluated. RESULTS--When adjusted for tobacco consumption, mother's age and pregnancy order, the odds ratio of the association between paternal exposure to approximately 5 ppm of benzene and the risk of spontaneous abortion was close to and statistically not different from unity (OR = 1.1; 95% CI (0.7-1.8). CONCLUSION--In this study paternal exposure to benzene did not increase the risk of spontaneous abortion.<\/jats:p>","DOI":"10.1136\/oem.51.7.475","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T00:14:48Z","timestamp":1229472888000},"page":"475-478","source":"Crossref","is-referenced-by-count":12,"title":["Occupational paternal exposure to benzene and risk of spontaneous abortion."],"prefix":"10.1136","volume":"51","author":[{"given":"I","family":"Str\u00fccker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Mandereau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Aubert-Berleur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"D\u00e9plan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Paris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Richard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"H\u00e9mon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1994,7,1]]},"reference":[{"key":"ref_1","first-page":"93","article-title":"Research on Cancer (IARC). Benzene. IARC Monogr Eval Carcinog Risks Hum","volume":"29","author":"International Agency of","year":"1987","unstructured":"International Agency of Research on Cancer (IARC). Benzene. IARC Monogr Eval Carcinog Risks Hum 1987; 29:93-148."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/10408448709089859","article-title":"Recent advances in the metabolism and toxicity of benzene","volume":"18","author":"Kalf, G.F.","year":"1987","unstructured":"Kalf GF. Recent advances in the metabolism and toxicity of benzene. Crit Rev Toxicol 1987;18:141-59.","journal-title":"Crit Rev Toxicol"},{"key":"ref_3","first-page":"127","article-title":"Cytogenetic analysis of peripheral blood lymphocytes in workers exposed to benzene","volume":"31","author":"Jablonicka, A.; Vargova, M.; Karelova, J.","year":"1987","unstructured":"Jablonicka A, Vargova M, Karelova J. Cytogenetic analysis of peripheral blood lymphocytes in workers exposed to benzene. J Hyg Epidemiol Microbiol Immunol 1987;31: 127-32.","journal-title":"J Hyg Epidemiol Microbiol Immunol"},{"key":"ref_4","first-page":"694","article-title":"Genotoxic effects in peripheral blood and urine of workers exposed to low level benzene","volume":"45","author":"Yardley-Jones, A.; Anderson, D.; Jenkison, P.C.; Lovell, D.P.; Blowers, S.D.; Davies, M.J.","year":"1988","unstructured":"Yardley-Jones A, Anderson D, Jenkison PC, Lovell DP, Blowers SD, Davies MJ. Genotoxic effects in peripheral blood and urine of workers exposed to low level benzene. BrJt Ind Med 1988;45:694-700.","journal-title":"BrJt Ind Med"},{"key":"ref_5","first-page":"48","article-title":"Analysis of chromosomal aberrations in workers exposed to low level benzene","volume":"47","author":"Yardley-Jones, A.; Anderson, D.; Lovell, D.P.; Jenkison, P.C.","year":"1990","unstructured":"Yardley-Jones A, Anderson D, Lovell DP, Jenkison PC. Analysis of chromosomal aberrations in workers exposed to low level benzene. BrJTInd Med 1990;47:48-51.","journal-title":"BrJTInd Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF00383594","article-title":"Sister chromatid exchange in peripheral lymphocytes of workers exposed to benzene, trichloroethylene, with references to smoking habits","volume":"62","author":"Seiji, K.; Jin, C.; Watanabe, T.; Nakatsuka, H.; Ikeda, M.","year":"1990","unstructured":"Seiji K, Jin C, Watanabe T, Nakatsuka H, Ikeda M. Sister chromatid exchange in peripheral lymphocytes of workers exposed to benzene, trichloroethylene, with references to smoking habits. Int Arch Occup Environ Health 1990;62: 171-6.","journal-title":"Int Arch Occup Environ Health"},{"key":"ref_7","first-page":"199","article-title":"Spontaneous abortions among women working in the pharmaceutical industry","volume":"43","author":"Taskinen, H.K.; Lindbohm, M.L.; Hemminki, K.","year":"1986","unstructured":"Taskinen HK, Lindbohm ML, Hemminki K. Spontaneous abortions among women working in the pharmaceutical industry. BrJ Ind Med 1986;43:199-205.","journal-title":"BrJ Ind Med"},{"key":"ref_8","first-page":"297","article-title":"Effects of parental occupational exposures on spontaneous abortion and congenital malformation. Scandj3 Work Environ","volume":"16","author":"Taskinen, H.K.","year":"1990","unstructured":"Taskinen HK. Effects of parental occupational exposures on spontaneous abortion and congenital malformation. Scandj3 Work Environ Health 1990;16:297-314.","journal-title":"Health"},{"key":"ref_9","first-page":"449","article-title":"Parental occupational exposure and spontaneous abortions in Finland","volume":"120","author":"Lindbohm, M.L.; Hemminki, K.; Kyyronen, P.","year":"1984","unstructured":"Lindbohm ML, Hemminki K, Kyyronen P. Parental occupational exposure and spontaneous abortions in Finland. Am J Epidemiol 1984;120:449-63.","journal-title":"Am J Epidemiol"},{"key":"ref_10","first-page":"193","article-title":"Paternal employment in solvent related occupations and adverse pregnancy outcomes","volume":"45","author":"Daniell, W.E.; Vaughan, T.L.","year":"1988","unstructured":"Daniell WE, Vaughan TL. Paternal employment in solvent related occupations and adverse pregnancy outcomes. Br J Ind Med 1988;45:193-7.","journal-title":"Br J Ind Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5271\/sjweh.1839","article-title":"Spontaneous abortions and congenital malformations among the wives of men occupationally exposed to organic solvents","volume":"15","author":"Taskinen, H.K.; Anttila, A.; Lindbohm, M.L.; Sallmen, M.; Hemminki, K.","year":"1989","unstructured":"Taskinen HK, Anttila A, Lindbohm ML, Sallmen M, Hemminki K. Spontaneous abortions and congenital malformations among the wives of men occupationally exposed to organic solvents. Scand J Work Environ Health 1989;15:345-52.","journal-title":"Scand J Work Environ Health"},{"key":"ref_12","first-page":"375","article-title":"Paternal exposure to mercury and spontaneous abortions","volume":"48","author":"Cordier, S.; Deplan, F.; Mandereau, L.; Hemon, D.","year":"1991","unstructured":"Cordier S, Deplan F, Mandereau L, Hemon D. Paternal exposure to mercury and spontaneous abortions. Br Y Ind Med 1991;48:375-81.","journal-title":"Br Y Ind Med"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oem.51.7.475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T13:43:34Z","timestamp":1716471814000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oem.51.7.475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":12,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1994,7,1]]},"published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1136\/oem.51.7.475"],"URL":"https:\/\/doi.org\/10.1136\/oem.51.7.475","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}