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Among 238 workers, without previous occupational exposure to rats, work related symptoms, which started after first employment at the site were related to exposure intensity (expressed either in terms of dust or of aeroallergen) at the time of onset of symptoms. These relations were stronger in atopic subjects but were unrelated to smoking. Positive skin tests to rat urinary extract were also more frequent with increased exposure, a relation found in both atopic subjects and in smokers. There was a strong association between work related symptoms and specific sensitisation.<\/jats:p>","DOI":"10.1136\/oem.51.9.589","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T00:14:48Z","timestamp":1229472888000},"page":"589-592","source":"Crossref","is-referenced-by-count":123,"title":["Work related symptoms, sensitisation, and estimated exposure in workers not previously exposed to laboratory rats."],"prefix":"10.1136","volume":"51","author":[{"given":"P","family":"Cullinan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Lowson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Nieuwenhuijsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R D","family":"Tee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K M","family":"Venables","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Newman Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1994,9,1]]},"reference":[{"key":"ref_1","first-page":"292","article-title":"Occupational respiratory disease in the United Kingdom: a report to the British Thoracic Society and the Society of Occupational Medicine by the SWORD Project Group","volume":"48","author":"Meredith, S.; Taylor, V.; McDonald, J.C.","year":"1991","unstructured":"Meredith S, Taylor V, McDonald JC. Occupational respiratory disease in the United Kingdom: a report to the British Thoracic Society and the Society of Occupational Medicine by the SWORD Project Group. BrJ Ind Med 1991;48:292-8.","journal-title":"BrJ Ind Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/00043764-198910000-00010","article-title":"Allergy to laboratory animals: a prospective and cross-sectional study","volume":"31","author":"Kibby, T.; Powell, G.; Cromer, J.","year":"1989","unstructured":"Kibby T, Powell G, Cromer J. Allergy to laboratory animals: a prospective and cross-sectional study. J Occup Med 1989;31:842-6.","journal-title":"J Occup Med"},{"key":"ref_3","first-page":"660","article-title":"Laboratory animal allergy in a pharmaceutical company","volume":"45","author":"Venables, K.M.; Tee, R.D.; Hawkins, R.","year":"1988","unstructured":"Venables KM, Tee RD, Hawkins R, et al. Laboratory animal allergy in a pharmaceutical company. 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