{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:48:20Z","timestamp":1777110500300,"version":"3.51.4"},"reference-count":26,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>OBJECTIVE--This is an update of an earlier study on the relation between exposure to arsenic in air and deaths from respiratory cancer. The purpose was to verify earlier findings of a supralinear dose response relation and to examine relations with other cancers, particularly those reported in studies on drinking water. METHODS--An earlier study of 2802 men who worked at a copper smelter for a year or more during the period 1940-64 and who were followed up for deaths during the period 1941-76 was updated until 1986. Estimates of exposure for the period 1977-1984 were added. RESULTS AND CONCLUSIONS--The additional follow up confirms the earlier finding that at low doses the increments in death rates for respiratory cancer for a given increment in dose are greater than at high doses. The additional follow up also shows significant increases in cancer of the large intestine and bone, and SMRs &gt; 150 for cancer of the buccal cavity and pharynx, rectal cancer, and kidney cancer. There was a positive relation between exposure to arsenic in air and kidney and bone cancer, but none for the other cancers, except respiratory.<\/jats:p>","DOI":"10.1136\/oem.52.1.28","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T00:14:48Z","timestamp":1229472888000},"page":"28-32","source":"Crossref","is-referenced-by-count":116,"title":["Cancers related to exposure to arsenic at a copper smelter."],"prefix":"10.1136","volume":"52","author":[{"given":"P E","family":"Enterline","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"key":"ref_1","first-page":"251","article-title":"Mortality study of copper smelter workers","volume":"1","author":"Enterline, P.E.; Marsh, G.M.","year":"1980","unstructured":"Enterline PE, Marsh GM. 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Osaka City MedJ7 1960; 9:2083-8.","journal-title":"Osaka City MedJ7"},{"key":"ref_26","first-page":"310","article-title":"Estimation of the body burden of arsenic in a child fatally poisoned by arsenite weed killer","volume":"13","author":"Jj, Saady; RV, Blanke; A, Poklis","year":"1989","unstructured":"Saady Jj, Blanke RV, Poklis A. Estimation of the body burden of arsenic in a child fatally poisoned by arsenite weed killer. 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