{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:55:15Z","timestamp":1790934915086,"version":"4.1.0"},"reference-count":15,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:p>OBJECTIVE--To measure the incidence of platinum salt sensitivity (PSS) in refinery workers and examine the influence of cigarette smoking and exposure to platinum salts on sensitisation. DESIGN--A prospective cohort study with examination of workers at quarterly intervals for 18 months, and again at 24 months. SETTING--A South African primary platinum refinery. SUBJECTS--78 new recruits, selected by the refinery's usual procedure, without apparent atopy and in good respiratory health. RESULTS--After 24 months 32 (41%) subjects had been diagnosed PSS and were subsequently medically separated. Twenty two (28%) cases were confirmed by positive skin prick test to platinum salts, 10 (13%) cases were symptomatic but skin prick negative. Incidence of cases per 100 person-months was 1.9 skin prick positive and 0.8 negative. Risk of sensitisation was about eight times greater for smokers than non-smokers, and six times greater for high exposure than low exposure. CONCLUSION--Smoking and intensity of exposure were definitely associated with development of PSS. Positive responses to platinum salt skin prick test had a 100% positive predictive value for symptoms and signs of PSS if exposure continued.<\/jats:p>","DOI":"10.1136\/oem.52.10.661","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T00:14:48Z","timestamp":1229472888000},"page":"661-666","source":"Crossref","is-referenced-by-count":104,"title":["Platinum salt sensitivity in refinery workers: incidence and effects of smoking and exposure."],"prefix":"10.1136","volume":"52","author":[{"given":"A E","family":"Calverley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Dowdeswell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Linnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kielkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1995,10,1]]},"reference":[{"key":"ref_1","first-page":"92","article-title":"Asthma caused by the complex salts of platinum","volume":"2","author":"Hunter, D.; Milton, R.; Perry, K.M.A.","year":"1945","unstructured":"Hunter D, Milton R, Perry KMA. 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Clin ImmunolAlergy 1984;4:131-57.","journal-title":"Clin ImmunolAlergy"},{"key":"ref_4","first-page":"37","article-title":"IgE antibody responses to platinum group metals: a large scale refinery survey","volume":"43","author":"Murdoch, R.D.; Pepys, J.; Hughes, E.G.","year":"1986","unstructured":"Murdoch RD, Pepys J, Hughes EG. IgE antibody responses to platinum group metals: a large scale refinery survey. BrJ Ind Med 1986;43:37-43.","journal-title":"BrJ Ind Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/ajim.4700180604","article-title":"Cross-sectional study of platinum salts sensitization among precious metals refinery workers","volume":"18","author":"Baker, D.B.; Gann, P.H.; Brooks, M.D.; Gallagher, J.; Bernstein, I.L.","year":"1990","unstructured":"Baker DB, Gann PH, Brooks MD, Gallagher J, Bernstein IL. Cross-sectional study of platinum salts sensitization among precious metals refinery workers. 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Journal of the Mine Medical Officers Association of South Africa 1987;63: 24-8.","journal-title":"Journal of the Mine Medical Officers Association of South Africa"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/occmed\/30.1.27","article-title":"Medical surveillance of platinum refinery workers","volume":"30","author":"Hughes, E.G.","year":"1980","unstructured":"Hughes EG. Medical surveillance of platinum refinery workers. I Soc Occup Med 1980;30:27-30.","journal-title":"I Soc Occup Med"},{"key":"ref_13","article-title":"Health and Safety Executive Occupational Medicine and Hygiene Laboratories. Platinum metal and soluble inorganic compounds ofplatinum in air. Methods for the deteination of hazardous substances MDHS 46","year":"1985","unstructured":"Health and Safety Executive Occupational Medicine and Hygiene Laboratories. Platinum metal and soluble inorganic compounds ofplatinum in air. Methods for the deteination of hazardous substances MDHS 46. London: HSE, 1985."},{"key":"ref_14","article-title":"Epi Info, Version 5","author":"Dean, A.D.; Dean, J.A.; Burton, J.H.; Dicker, R.C.","year":"1990","unstructured":"Dean AD, Dean JA, Burton JH, Dicker RC. Epi Info, Version 5. Atlanta, Georgia: Centres for Disease Control, USA, 1990."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1378\/chest.97.6.1401","article-title":"Cold air challenge and platinum skin reactivity in platinum refinery workers","volume":"97","author":"Brooks, S.M.; Baker, D.B.; Gann, P.H.; Jarabek, A.M.; Herzberg, V.; Gallagher, J.","year":"1990","unstructured":"Brooks SM, Baker DB, Gann PH, Jarabek AM, Herzberg V, Gallagher J, et al. Cold air challenge and platinum skin reactivity in platinum refinery workers. 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