{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:04:43Z","timestamp":1769159083932,"version":"3.49.0"},"reference-count":25,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:p>BACKGROUND--It has been suggested that health related job selection is a major cause of the healthy worker effect, and may result in inaccurate estimates of health risks of exposures in the working environment. Improved understanding of self selection, including the role of airway hyperresponsiveness, should improve accuracy in estimating occupational risks. METHODS--We evaluated symptoms of the respiratory tract, lung function, occupational and smoking histories, and airway responsiveness from a cross sectional survey of 478 underground bituminous coal miners and non-mining controls. Workers with abnormal spirometry were excluded from methacholine testing. RESULTS--Methacholine responsiveness (&gt; or = 15% decline in forced expiratory volume in one second) was associated in both miners and controls with reduced ventilatory lung function and an increased risk of respiratory symptoms. Miners with the longest duration of work at the coal face had a low prevalence of methacholine responsiveness, compared with miners who had never worked at the coal face (12% v 39%, P &lt; 0.01). Throughout their mining careers, miners who responded to methacholine were consistently less likely to have worked in dusty jobs than miners who did not respond to methacholine. CONCLUSIONS--These results provide evidence that workers who are employed in dusty jobs are less likely than their unexposed coworkers to show increased non-specific airway responsiveness, presumably as a result of health related job selection. Surveys of workers in which responsiveness data are unavailable may underestimate the effects of dust exposure on respiratory health.<\/jats:p>","DOI":"10.1136\/oem.52.11.745","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T00:14:48Z","timestamp":1229472888000},"page":"745-749","source":"Crossref","is-referenced-by-count":24,"title":["Airway responsiveness and job selection: a study in coal miners and non-mining controls."],"prefix":"10.1136","volume":"52","author":[{"given":"E L","family":"Petsonk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M","family":"Daniloff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Mannino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Short","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G R","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1995,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1378\/chest.88.4.608","article-title":"Chronic airflow limitation: its relationship to work in dusty occupations","volume":"88","author":"Becklake, M.R.","year":"1985","unstructured":"Becklake MR. 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Prognostic test: a prospective study. value of acetylcholine challenge Med 1984;41:267-71."},{"key":"ref_12","first-page":"167","article-title":"Prognostic value of a positive acetycholine test regarding VC and FEV, in coal-miners with a history of chronic bronchitis","volume":"14","author":"Minette, A.; Marcq, M.; Gepts, L.","year":"1978","unstructured":"Minette A, Marcq M, Gepts L. Prognostic value of a positive acetycholine test regarding VC and FEV, in coal-miners with a history of chronic bronchitis. Bulletin European de Physiopathology Respiratoire 1978;14: 167-75.","journal-title":"Bulletin European de Physiopathology Respiratoire"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/thx.44.2.116","article-title":"Relation of airway responsiveness to duration of work in a dusty environment","volume":"44","author":"Ernst, P.; Dales, R.E.; Nunes, F.; Becklake, M.R.","year":"1989","unstructured":"Ernst P, Dales RE, Nunes F, Becklake MR. Relation of airway responsiveness to duration of work in a dusty environment. Thorax 1989;44: 116-20.","journal-title":"Thorax"},{"key":"ref_14","first-page":"4","article-title":"American Thoracic Society. Standardizationof spirometry","volume":"119","year":"1979","unstructured":"American Thoracic Society. Standardizationof spirometry. Am Rev ofRespirDis 1979;119:4-11.","journal-title":"Am Rev ofRespirDis"},{"key":"ref_15","first-page":"57","article-title":"Spirometric standards for healthy non-smoking adults","volume":"103","author":"Morris, J.F.; Koski, A.; Johnson, L.C.","year":"1971","unstructured":"Morris JF, Koski A, Johnson LC. Spirometric standards for healthy non-smoking adults. Am Rev Respir Dis 1971; 103:57-67.","journal-title":"Am Rev Respir Dis"},{"key":"ref_16","first-page":"15","article-title":"A screening test for airway reactivity: an abbreviated methacholine inhalation challenge","volume":"1","author":"Chatham, M.; Bleecker, E.R.; Smith, Norman P.; PL, Mason; P.","year":"1982","unstructured":"Chatham M, Bleecker ER, Norman P. Smith PL, Mason P. A screening test for airway reactivity: an abbreviated methacholine inhalation challenge. Chest 1982;1: 15-8.","journal-title":"Chest"},{"key":"ref_17","first-page":"325","article-title":"GR Respiratory disease in coal miners","volume-title":"Environmental and occupational medicine","author":"Attfield, M.A.; Wagner","year":"1992","unstructured":"Attfield MA, Wagner GR Respiratory disease in coal miners. In: Rom WN, ed. Environmental and occupational medicine, 2nd edition. 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Am Rev Respir Dis 1992;146:46-52.","journal-title":"Am Rev Respir Dis"},{"key":"ref_20","article-title":"Characterization of the 1986 coal mining workforce","author":"Butani, S.J.; Bartholomew, A.M.","year":"9192","unstructured":"Butani SJ, Bartholomew AM. Characterization of the 1986 coal mining workforce. United States Department of Interior, Bureau of Mines, 1988. (Information Circular 9192)."},{"key":"ref_21","first-page":"43","article-title":"The host factor in bronchitis","author":"Orie, N.G.M.; Sluiter, H.J.; de Vries, K.","year":"1961","unstructured":"Orie NGM, Sluiter HJ, de Vries K, et al. The host factor in bronchitis. In: Orie NGM, Sluiter HJ, eds. Bronchitis. Assen: Royal Van Gorcum, 1961:43-59."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1378\/chest.86.1.3","article-title":"Increased levels of airway responsiveness as a risk factor for development of chronic obstructive lung disease","volume":"86","author":"Weiss, S.T.; Speizer, F.E.","year":"1984","unstructured":"Weiss ST, Speizer FE. Increased levels of airway responsiveness as a risk factor for development of chronic obstructive lung disease. Chest 1984;86:3-4.","journal-title":"Chest"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1378\/chest.85.6.782","article-title":"Host factors affecting longitudinal decline in lung spirometry among grain elevator workers","volume":"85","author":"Tabona, M.; Chan-Yeung, M.; Enarson, D.; MacLean, L.; Dorken, E.; Schulzer, M.","year":"1984","unstructured":"Tabona M, Chan-Yeung M, Enarson D, MacLean L, Dorken E, Schulzer M. Host factors affecting longitudinal decline in lung spirometry among grain elevator workers. Chest 1984;85:782-6.","journal-title":"Chest"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1378\/chest.86.1.54","article-title":"The relationship between airways responsiveness and chronic airflow limitation","volume":"86","author":"Kanner, R.E.","year":"1984","unstructured":"Kanner RE. The relationship between airways responsiveness and chronic airflow limitation. Chest 1984;86:54-7.","journal-title":"Chest"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000195837","article-title":"The 'healthy smoker': a phenomenon of health selection?","volume":"57","author":"U, Becklake M.R.Lalloo","year":"1990","unstructured":"Becklake MR. Lalloo U. The 'healthy smoker': a phenomenon of health selection? 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