{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:16:34Z","timestamp":1790860594420,"version":"4.1.0"},"reference-count":28,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:p>OBJECTIONS: To ascertain whether certain occupations are associated with laryngeal or hypopharyngeal cancer. METHODS: A hospital based case-control study was carried out in 15 hospitals in France. It included 528 male cases diagnosed between January 1989 and April 1991, and 305 male controls with various other types of cancer. Interviews were carried out to obtain lifetime job histories and information on potential confounders. Logistic regression was used to compute the odds ratios (OR) for each of about 80 occupations and industries. RESULTS: There was an excess risk of laryngeal and hypopharyngeal cancer among service workers (OR 2.2, 95% confidence interval (95% CI) 1.3 to 3.9), agricultural and animal husbandry workers (OR 1.6, 95% CI 0.9 to 2.8), miners and quarrymen (OR 2.0, 95% CI 0.9 to 4.3), plumbers and pipe fitters (OR 2.6, 95% CI 0.8 to 8.1), glass formers and potters (OR 4.3, 95% CI 1.0 to 18) transport equipment operators (OR 1.5, 95% CI 1.0 to 2.5), and unskilled workers (OR 1.7, 95% CI 1.0 to 2.9). Analysis by industrial branch showed an excess risk for coal mining (OR 2.1, 95% CI 1.1 to 4.1), manufacture of metal products (OR 1.9, 95% CI 1.0 to 3.3), and administration and sanitary services (OR 1.7, 95% CI 1.1 to 2.5). CONCLUSION: These results suggest that occupational exposure might have a role in generating laryngeal and hypopharyngeal cancer, and indicate the need for further evaluation of these findings, an for the identification of the carcinogens which might account for the excess risks found for certain occupations.<\/jats:p>","DOI":"10.1136\/oem.54.7.477","type":"journal-article","created":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T19:14:48Z","timestamp":1229454888000},"page":"477-482","source":"Crossref","is-referenced-by-count":43,"title":["Laryngeal and hypopharyngeal cancer and occupation: results of a case control-study."],"prefix":"10.1136","volume":"54","author":[{"given":"P","family":"Goldberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Leclerc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Luce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J F","family":"Morcet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Brug\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1997,7,1]]},"reference":[{"key":"ref_1","article-title":"Cancer incidence in five continents","author":"Parkin, D.M.; Muir, C.S.; Whelan, S.L.; Gao, Y.T.; Ferlay, J.; Powell, J.","year":"1992","unstructured":"Parkin DM, Muir CS, Whelan SL, Gao YT, Ferlay J, Powell J. Cancer incidence in five continents. Vol VI. Lyon: IARC, 1992."},{"key":"ref_2","article-title":"International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans: alcohol drinking","volume":"44","year":"1988","unstructured":"International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans: alcohol drinking. Vol 44. Lyon: IARC, 1988.","journal-title":"Vol"},{"key":"ref_3","article-title":"International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks of chemicals to humans: tobacco smoking. Vol 38","year":"1986","unstructured":"International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks of chemicals to humans: tobacco smoking. Vol 38. Lyon: IARC, 1986."},{"key":"ref_4","first-page":"483","article-title":"Cancer of the larynx\/hypopharynx, tobacco and alcohol: IARC international case-control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain)","volume":"41","author":"Tuyns, A.J.; Esteve, J.; Raymond, L.; Berrino, F.; Benhamou, E.; Blanchet, F.","year":"1988","unstructured":"Tuyns AJ, Esteve J, Raymond L, Berrino F, Benhamou E, Blanchet F, et al. Cancer of the larynx\/hypopharynx, tobacco and alcohol: IARC international case-control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain), Geneva (Switzerland), and Calvados (France). Int _7 Cancer 1988;41:483-91.","journal-title":"Geneva (Switzerland), and Calvados (France). Int _7 Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/jech.42.4.350","article-title":"A study of the interaction of alcohol drinking and tobacco smoking among French cases of laryngeal cancer","volume":"42","author":"JF, Gubnel P.Chastang; D, Luce; A, Leclerc; J, Brughre","year":"1988","unstructured":"Gubnel P. Chastang JF, Luce D, Leclerc A, Brughre J. A study of the interaction of alcohol drinking and tobacco smoking among French cases of laryngeal cancer. 7 Epidemiol Community Health 1988;42:350-4.","journal-title":"7 Epidemiol Community Health"},{"key":"ref_6","first-page":"211923","article-title":"Alcohol and cancer","volume":"52","author":"Blot, W.J.","year":"1992","unstructured":"Blot WJ. Alcohol and cancer. Cancer Res 1992;52:S211923.","journal-title":"Cancer Res"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ajim.4700200404","article-title":"Alcohol, smoking, and occupational factors in cancer of the larynx: a case-control study","volume":"20","author":"Ahrens, W.; Jockel, K.H.; Patzak, W.; Elsner, G.","year":"1991","unstructured":"Ahrens W, Jockel KH, Patzak W, Elsner G. Alcohol, smoking, and occupational factors in cancer of the larynx: a case-control study. Am. Ind Med 1991;20:477-93.","journal-title":"Am. Ind Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/oxfordjournals.aje.a116484","article-title":"Diet and other risk factors for laryngeal cancer in Shanghai, China","volume":"136","author":"Zheng, W.; Wj, Blot; Shu, X.O.; Gao, Y.T.; Ji, B.T.; Ziegler, R.G.; Fraumeni, J.F.","year":"1992","unstructured":"Zheng W, Blot Wj, Shu XO, Gao YT, Ji BT, Ziegler RG, Fraumeni JF. Diet and other risk factors for laryngeal cancer in Shanghai, China. Am j Epidemiol 1992;136:178-91.","journal-title":"Am j Epidemiol"},{"key":"ref_9","first-page":"1219","article-title":"and nickel in the etiology of cancer of the larynx: a case-control study","volume":"67","author":"Burch, J.D.; Howe, G.R.; Miller, A.B.; Tobacco, Semenciw R.; alcohol, asbestos","year":"1981","unstructured":"Burch JD, Howe GR, Miller AB, Semenciw R. Tobacco, alcohol, asbestos, and nickel in the etiology of cancer of the larynx: a case-control study. _7 Natl Cancer Inst 1981;67: 1219-24."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/oxfordjournals.aje.a114371","article-title":"Occupational risk factors for laryngeal carcinoma: Connecticut","volume":"124","author":"Zagraniski, R.T.; Kelsey, J.L.; Walter, S.D.","year":"1975","unstructured":"Zagraniski RT, Kelsey JL, Walter SD. Occupational risk factors for laryngeal carcinoma: Connecticut, 1975-80. Am J Epidemiol 1986;124:67-76.","journal-title":"Am J Epidemiol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1002\/1097-0142(19920501)69:9<2244::AID-CNCR2820690906>3.0.CO;2-O","article-title":"and occupational risk factors for laryngeal cancer","volume":"69","author":"Muscat, J.E.; Tobacco, Wynder E.L.; alcohol, asbestos","year":"1992","unstructured":"Muscat JE, Wynder EL. Tobacco, alcohol, asbestos, and occupational risk factors for laryngeal cancer. Cancer 1992; 69:2244-51.","journal-title":"Cancer"},{"key":"ref_12","first-page":"837","article-title":"A case-control study of occupational risk factors for laryngeal cancer","volume":"49","author":"Wortley, P.; Vaughan, T.L.; Davis, S.; Morgan, M.S.; Thomas, D.B.","year":"1992","unstructured":"Wortley P, Vaughan TL, Davis S, Morgan MS, Thomas DB. A case-control study of occupational risk factors for laryngeal cancer. BrJt Ind Med 1992;49:837-44.","journal-title":"BrJt Ind Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00001648-199207000-00005","article-title":"Oral and pharyngeal cancer and occupation: a case-control study","volume":"3","author":"Huebner, W.W.; Schoenberg, J.B.; Kelsey, J.L.; Wilcox, H.B.; McLaughlin, J.K.; Greenberg, R.S.","year":"1992","unstructured":"Huebner WW, Schoenberg JB, Kelsey JL, Wilcox HB, McLaughlin JK, Greenberg RS, et al. Oral and pharyngeal cancer and occupation: a case-control study. Epidemiology 1992;3:300-9.","journal-title":"Epidemiology"},{"key":"ref_14","first-page":"530","article-title":"Berufliche Risikofaktoren fuir Rachenkrebs","volume":"42","author":"Maier, H.; Fisher, G.; Sennewald, E.; Heller, W.D.","year":"1994","unstructured":"Maier H, Fisher G, Sennewald E, Heller WD. Berufliche Risikofaktoren fuir Rachenkrebs. HNO 1994;42:530-40.","journal-title":"HNO"},{"key":"ref_15","first-page":"81","article-title":"Occupational factors of upper respiratory tract cancers","volume-title":"Prevention of respiratory diseases. Lung biology in health and disease 68","author":"Berrino, F.","year":"1993","unstructured":"Berrino F. Occupational factors of upper respiratory tract cancers. In: Hirsch A, Goldberg M, Martin JP, Masse R, eds. Prevention of respiratory diseases. Lung biology in health and disease 68. New York: M Dekker, 1993:81-96."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/1047322X.1991.10387918","article-title":"The occupational questionnaire in retrospective epidemiologic studies: recent approaches in community-based studies","volume":"6","author":"Grin, M.; Siemiatycki, J.","year":"1991","unstructured":"Grin M, Siemiatycki J. The occupational questionnaire in retrospective epidemiologic studies: recent approaches in community-based studies. Appl Occup Environ Hyg 1991;6: 495-501.","journal-title":"Appl Occup Environ Hyg"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ajim.4700210206","article-title":"Occupational risk factors for sinonasal cancer: a case-control study in France","volume":"21","author":"Luce, D.; Leclerc, A.; Morcet, J.F.; Casal-Lareo, A.; Gerin, M.; Brugere, J.","year":"1992","unstructured":"Luce D, Leclerc A, Morcet JF, Casal-Lareo A, Gerin M, Brugere J, et al. Occupational risk factors for sinonasal cancer: a case-control study in France. Anm 7 Ind Med 1992;21:163-75.","journal-title":"Anm 7 Ind Med"},{"key":"ref_18","article-title":"International standard classification of occupations. Revised 1968","author":"Office, International Labour","year":"1969","unstructured":"International Labour Office. International standard classification of occupations. Revised 1968. Geneva: BIT, 1969."},{"key":"ref_19","article-title":"Statistical Office of the United Nations","volume-title":"papers series M, number 4, revision 2","year":"1968","unstructured":"Statistical Office of the United Nations. International standard industrial classification of all economic activities.NewYork: United Nations, 1968. (Statistical papers series M, number 4, revision 2.)"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/oxfordjournals.aje.a117737","article-title":"Multiple comparisons and related issues in the interpretation of epidemiologic data","volume":"142","author":"Savitz, D.A.; Olshan, A.F.","year":"1995","unstructured":"Savitz DA, Olshan AF. Multiple comparisons and related issues in the interpretation of epidemiologic data. Am 7 Epidemiol 1995;142:904-8.","journal-title":"Am 7 Epidemiol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5271\/sjweh.1585","article-title":"Occupational exposure to sulfuric acid in Southern Ontario","volume":"18","author":"Soskolne, C.L.; Jhangri, G.S.; Siemiatycki, J.; Lakhani, R.; Dewar, R.; Burch, J.D.","year":"1992","unstructured":"Soskolne CL, Jhangri GS, Siemiatycki J, Lakhani R, Dewar R, Burch JD, et al. Occupational exposure to sulfuric acid in Southern Ontario, Canada, in association with laryngeal cancer. Scandj7 Work Environ Health 1992;18:225-32.","journal-title":"Work Environ Health"},{"key":"ref_22","first-page":"44","article-title":"Kehlkopfkarzinom und Berufstatigkeit Ergebnisse der Heidelberger Kehlkopfkrebsstudie","volume":"40","author":"Maier, H.; Gewelke, U.; Dietz, A.; Thamm, H.; Heller, W.D.; Weidauer, H.","year":"1992","unstructured":"Maier H, Gewelke U, Dietz A, Thamm H, Heller WD, Weidauer H. Kehlkopfkarzinom und Berufstatigkeit Ergebnisse der Heidelberger Kehlkopfkrebsstudie. HNO 1992; 40:44-51.","journal-title":"HNO"},{"key":"ref_23","first-page":"380","article-title":"Occupational risk factors for upper respiratory tract and upper digestive tract cancers","volume":"47","author":"Haguenoer, J.M.; Cordier, S.; Morel, C.; Lefebvre, J.L.; Hemon, D.","year":"1990","unstructured":"Haguenoer JM, Cordier S, Morel C, Lefebvre JL, Hemon D. Occupational risk factors for upper respiratory tract and upper digestive tract cancers. Br.7Ind Med 1990;47:380-3.","journal-title":"Br.7Ind Med"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/00043764-199006000-00005","article-title":"Epidemiological evidence indicates asbestos causes laryngeal cancer","volume":"32","author":"Smith, A.H.; Handley, M.A.; Wood, R.","year":"1990","unstructured":"Smith AH, Handley MA, Wood R. Epidemiological evidence indicates asbestos causes laryngeal cancer.. Occup Med 1990;32:499-507.","journal-title":"Occup Med"},{"key":"ref_25","first-page":"810","article-title":"An update of cancer mortality among chrysotile asbestos miners in Balangero, nothern Italy","volume":"47","author":"Piolatto, G.; Negri, E.; La Vecchia, C.; Pira, E.; Decarli, A.; Peto, J.","year":"1990","unstructured":"Piolatto G, Negri E, La Vecchia C, Pira E, Decarli A, Peto J. An update of cancer mortality among chrysotile asbestos miners in Balangero, nothern Italy. Br.7 Ind Med 1990;47: 810-4.","journal-title":"Br.7 Ind Med"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/ajim.4700220604","article-title":"Mortality studies of machining fluid exposure in the automobile industry I: a standardized mortality ratio analysis","volume":"22","author":"Eisen, E.A.; Tolbert, P.E.; Monson, R.R.; Smith, T.J.","year":"1992","unstructured":"Eisen EA, Tolbert PE, Monson RR, Smith TJ. Mortality studies of machining fluid exposure in the automobile industry I: a standardized mortality ratio analysis. Am.7 Ind Med 1992;22:809-24.","journal-title":"Am.7 Ind Med"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/ajim.4700260205","article-title":"Mortality studies of machining fluid exposure in the automobile industry III: a case-control study of larynx cancer","volume":"26","author":"Eisen, E.A.; Tolbert, P.E.; Hallock, M.F.; Monson, R.R.; Smith, T.J.; Woskie, SR","year":"1994","unstructured":"Eisen EA, Tolbert PE, Hallock MF, Monson RR, Smith TJ, Woskie SR. Mortality studies of machining fluid exposure in the automobile industry III: a case-control study of larynx cancer. Am j Ind Med 1994;26:185-202.","journal-title":"Am j Ind Med"},{"key":"ref_28","first-page":"473","article-title":"Laryngeal cancer in Denmark: a nationwide longitudinal study based on register linkage data","volume":"47","author":"Guknel, P.; Engholm, G.; Lynge, E.","year":"1990","unstructured":"Guknel P, Engholm G, Lynge E. Laryngeal cancer in Denmark: a nationwide longitudinal study based on register linkage data. Br7 Ind Med 1990;47:473-9.","journal-title":"Br7 Ind Med"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oem.54.7.477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T12:35:29Z","timestamp":1716467729000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oem.54.7.477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":28,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1997,7,1]]},"published-print":{"date-parts":[[1997,7]]}},"alternative-id":["10.1136\/oem.54.7.477"],"URL":"https:\/\/doi.org\/10.1136\/oem.54.7.477","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,7]]}}}