{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:54:59Z","timestamp":1777424099454,"version":"3.51.4"},"reference-count":48,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:p>OBJECTIVES: To investigate the effects of lead and cadmium on the metabolic pathway of vitamin D3. METHODS: Blood and urinary cadmium and urinary total proteins were measured in 59 smelter workers occupationally exposed to lead and cadmium. In 19 of these workers, the plasma vitamin D3 metabolites, (25-hydroxycholecalciferol (25 OHD3), 24R, 25-dihydroxycholecalciferol (24R,25(OH)2D3) and 1 alpha,25-dihydroxycholecalciferol (1 alpha, 25(OH)2D3)) were measured together with blood lead. Vitamin D3 metabolites were measured by radioimmunoassay, (RIA), lead and cadmium by atomic absorption spectrophotometry, and total proteins with a test kit. RESULTS: Ranges for plasma 25(OH)D3, 24R,25(OH)2D3 and 1 alpha,25(OH)2D3 were 1.0-51.9 ng\/ml, 0.6-5.8 ng\/ml, and 0.1-75.7 pg\/ml, respectively. Ranges for blood lead were 1-3.7 mumol\/l, (21-76 micrograms\/dl), blood cadmium 6-145 nmol\/l, and urinary cadmium 3-161 nmol\/l. Total proteins in random urine samples were 2.1-32.6 mg\/dl. Concentrations of lead and cadmium in blood showed no correlation (correlation coefficient -0.265) but there was a highly significant correlation between blood and urinary cadmium. Concentrations for 24R,25(OH)2D3 were depressed below the normal range as blood and urinary cadmium increased, irrespective of lead concentrations. High cadmium concentrations were associated with decreased plasma 1 alpha,25(OH)2D3 when lead concentrations were &lt; 1.9 mumol\/l and with above normal plasma 1 alpha,25(OH)2D3 when lead concentrations were &gt; 1.9 mumol\/l, Kruskal-Wallis analysis of variance (K-W ANOVA) chi 2 = 10.3, p = 0.006. Plasma 25(OH)D3 was negatively correlated with both urinary total proteins and urinary cadmium, but showed no correlation with plasma 24R,25(OH)2D3, 1 alpha,25(OH)2D3, blood lead, or blood cadmium. CONCLUSION: Continuous long term exposure to cadmium may result in a state of equilibrium between blood and urinary cadmium. Cadmium concentrations in blood could be predicted from the cadmium concentration of the urine, (regression coefficient +0.35 SE 0.077). Exposure to cadmium alone decreased the concentrations of 1 alpha,25(OH)2D3 and 24R,25(OH)2D3, whereas exposure to both cadmium and lead increased the concentrations of 1 alpha,25(OH)2D3. It has been suggested that cadmium and lead interact with renal mitochondrial hydroxylases of the vitamin D3 endocrine complex. Perturbation of the vitamin D metabolic pathway by cadmium may result in health effect, such as osteoporosis or osteomalacia, risks which are possibly increased in the presence of lead.<\/jats:p>","DOI":"10.1136\/oem.55.7.446","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:13:30Z","timestamp":1230768810000},"page":"446-452","source":"Crossref","is-referenced-by-count":60,"title":["Measurement of vitamin D3 metabolites in smelter workers exposed to lead and cadmium."],"prefix":"10.1136","volume":"55","author":[{"given":"S R","family":"Chalkley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Richmond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Barltrop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0009-9120(93)90113-K","article-title":"Perspectives on lead toxicity","volume":"26","author":"Lockitch, G.","year":"1993","unstructured":"Lockitch G. Perspectives on lead toxicity [review]. Clin Biochem 1993;26:371\u201381.","journal-title":"Clin Biochem"},{"key":"ref_2","first-page":"133","article-title":"Influence of dietary iron deficiency on acute metal intoxication","volume":"6","author":"Tandon, S.K.; Khandelwal, S.; Jain, V.K.","year":"1993","unstructured":"Tandon SK, Khandelwal S, Jain VK, et al. Influence of dietary iron deficiency on acute metal intoxication. Biometals 1993;6:133\u20138","journal-title":"Biometals"},{"key":"ref_3","first-page":"339","article-title":"Lead concentrations in human tissues","volume":"27","author":"Barry, P.S.; Mossman, D.B.","year":"1970","unstructured":"Barry PS, Mossman DB. Lead concentrations in human tissues. Br J Ind Med 1970;27:339\u201351.","journal-title":"Br J Ind Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1006\/taap.1996.0209","article-title":"EVects of lead on growth-plate chondrocyte phenotype","volume":"140","author":"Hicks, D.G.; O\u2019Keefe, R.J.; Reynolds, K.J.","year":"1996","unstructured":"Hicks DG, O\u2019Keefe RJ, Reynolds KJ, et al. EVects of lead on growth-plate chondrocyte phenotype. Toxicol Appl Pharmacol 1996;140:164\u201372.","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1080\/00039899709602872","article-title":"Lead in fingerbone: a tool for retrospective exposure assessment","volume":"52","author":"Borjesson, J.; Mattsson, S.; Stromberg, U.","year":"1997","unstructured":"Borjesson J, Mattsson S, Stromberg U, et al. Lead in fingerbone: a tool for retrospective exposure assessment. Arch Environ Health 1997;52:104\u201312.","journal-title":"Arch Environ Health"},{"key":"ref_6","first-page":"301","article-title":"Mechanism and epidemiology of bone eVects of cadmium","volume":"118","author":"Kjellstrom, T.","year":"1992","unstructured":"Kjellstrom T. Mechanism and epidemiology of bone eVects of cadmium. IARC Sci Publ 1992;118:301\u2013310.","journal-title":"IARC Sci Publ"},{"key":"ref_7","first-page":"37","article-title":"Markers of early renal changes induced by industrial pollutants. III. Application to workers exposed to cadmium","volume":"50","author":"Roels, H.; Bernard, A.M.; Cardenas, A.","year":"1993","unstructured":"Roels H, Bernard AM, Cardenas A, et al. Markers of early renal changes induced by industrial pollutants. III. Application to workers exposed to cadmium. Br J Ind Med 1993;50:37\u201348.","journal-title":"Br J Ind Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0378-4274(85)90057-8","article-title":"1-Microglobulin determination in urine for the early detection of renal tubular dysfunctions caused by exposure to cadmium","volume":"24","author":"Hido, T.; Honda, R.; Yamada, Y.","year":"1985","unstructured":"Hido T, Honda R, Yamada Y, et al. 1-Microglobulin determination in urine for the early detection of renal tubular dysfunctions caused by exposure to cadmium. Toxicol Lett 1985;24:195\u2013201.","journal-title":"Toxicol Lett"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0021-9258(18)85139-0","volume":"61","author":"Steenbock, H.; Vitamin, Black A.; D.","year":"1924","unstructured":"Steenbock H, Black A. Vitamin D. J Biol Chem 1924;61:405.","journal-title":"J Biol Chem"},{"key":"ref_10","first-page":"11","article-title":"Holick MF. The cutaneous photosynthesis of pre-vitamin","volume":"62","author":"Hess, A.F.; Vitamin, Weinstock M.; D.","year":"1924","unstructured":"Hess AF, Weinstock M. Vitamin D. J Biol Chem 1924;62: 11 Holick MF. The cutaneous photosynthesis of pre-vitamin","journal-title":"J Biol Chem"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0024-3205(91)90355-F","article-title":"The existence of 25-hydroxyvitamin D3\u20131 alpha-hydroxylase in the liver of carp and bastard halibut","volume":"48","author":"Takeuchi, A.; Okano, T.; Kobayashi, T.","year":"1991","unstructured":"Takeuchi A, Okano T, Kobayashi T. The existence of 25-hydroxyvitamin D3\u20131 alpha-hydroxylase in the liver of carp and bastard halibut. 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Biochem J 1989;259:561\u20138.","journal-title":"Biochem J"},{"key":"ref_14","first-page":"1","article-title":"Monoclonal antibodies to chick renal calcium regulating hemeproteins. Biochemical and immunohistochemical interactions with mitochondrial 25-hydroxyvitamin D3 hydroxylases","volume":"31","author":"Mandel, M.L.; Moorthy, B.; Swartz, S.J.","year":"1990","unstructured":"Mandel ML, Moorthy B, Swartz SJ, et al. Monoclonal antibodies to chick renal calcium regulating hemeproteins. Biochemical and immunohistochemical interactions with mitochondrial 25-hydroxyvitamin D3 hydroxylases. J Clin Lab Immunol 1990;31:1\u201310.","journal-title":"J Clin Lab Immunol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/1523-1747.ep12378190","article-title":"Production of 1,25 dihydroxyvitamin D3 by perfused pig skin","volume":"102","author":"Bikle, D.D.; Halloran, B.P.; Riviere, J.E.","year":"1994","unstructured":"Bikle DD, Halloran BP, Riviere JE. Production of 1,25 dihydroxyvitamin D3 by perfused pig skin. J Invest Dermatol 1994;102:796\u20138.","journal-title":"J Invest Dermatol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2340\/0001555570351354","article-title":"Vitamin D metabolism in psoriasis before and after phototherapy","volume":"70","author":"Guilhou, J.J.; Colette, C.; Monpoint, S.","year":"1990","unstructured":"Guilhou JJ, Colette C, Monpoint S, et al. Vitamin D metabolism in psoriasis before and after phototherapy. Acta Derm Venereol 1990;70:351\u20134.","journal-title":"Acta Derm Venereol"},{"key":"ref_17","series-title":"Prog Clin Biol Res","first-page":"99","article-title":"Recent studies on the biological actions of vitamin D on intestinal transport and the electrophysiology of peripheral nerve and cardiac muscle","volume":"332","author":"Wasserman, R.H.; Brindak, M.E.; Buddle, M.M.","year":"1990","unstructured":"Wasserman RH, Brindak ME, Buddle MM, et al. Recent studies on the biological actions of vitamin D on intestinal transport and the electrophysiology of peripheral nerve and cardiac muscle [review]. Prog Clin Biol Res 1990;332:99\u2013 126."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/BF02207080","article-title":"Calcium and vitamin D metabolism in granulomatous diseases","volume":"11","author":"Fuss, M.; Pepersack, T.; Gillet, C.","year":"1992","unstructured":"Fuss M, Pepersack T, Gillet C, et al. Calcium and vitamin D metabolism in granulomatous diseases. Clin Rheumatol 1992;11:28\u201336.","journal-title":"Clin Rheumatol"},{"key":"ref_19","first-page":"893","article-title":"Vitamin D","volume":"51","author":"Miyaura, C.; Suda, T.","year":"1993","unstructured":"Miyaura C, Suda T. Vitamin D [review]. Jap J Clin Med 1993;51:893\u2013900. [Japanese]","journal-title":"Jap J Clin Med"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0169-6009(91)90127-L","article-title":"24,25(OH)2D3 aVects the calcemic eVects of 1,25(OH)2D3 by mechanisms independent of intestinal calcium absorption","volume":"15","author":"Rubinger, D.; Krause, I.; Alkoby-Gibbs, M.","year":"1991","unstructured":"Rubinger D, Krause I, Alkoby-Gibbs M, et al. 24,25(OH)2D3 aVects the calcemic eVects of 1,25(OH)2D3 by mechanisms independent of intestinal calcium absorption. Bone and Mineral 1991;15:219\u201326.","journal-title":"Bone and Mineral"},{"key":"ref_21","first-page":"161","article-title":"EVect of 24,25- dihydroxyvitamin","volume-title":"D3 in osteoclasts. Proc Soc Exp Biol Med","author":"Matsumoto, T.; Yamato, H.; Okazaki, R.","year":"1992","unstructured":"Matsumoto T, Yamato H, Okazaki R, et al. EVect of 24,25- dihydroxyvitamin D3 in osteoclasts. Proc Soc Exp Biol Med 1992;200:161\u20134."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF00298729","article-title":"EVect of 24R,25dihydroxyvitamin D3 on the formation and function of osteoclastic cells","volume":"52","author":"Yamato, H.; Okazaki, R.; Ishii, T.","year":"1993","unstructured":"Yamato H, Okazaki R, Ishii T, et al. EVect of 24R,25dihydroxyvitamin D3 on the formation and function of osteoclastic cells. Calcif Tissue Int 1993;52:255\u201360.","journal-title":"Calcif Tissue Int"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/jbmr.5650080906","article-title":"Oscillations in inositol 1,4,5-trisphosphate and diacyglycerol induced by vitamin D3 metabolites in confluent mouse osteoblasts","volume":"8","author":"Grosse, B.; Bourdeau, A.; Lieberherr, M.","year":"1993","unstructured":"Grosse B, Bourdeau A, Lieberherr M. Oscillations in inositol 1,4,5-trisphosphate and diacyglycerol induced by vitamin D3 metabolites in confluent mouse osteoblasts. J Bone Miner Res 1993;8:1059\u201369.","journal-title":"J Bone Miner Res"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0013-9351(05)80185-9","article-title":"EVect of dietary calcium and lead status on intestinal calcium absorption","volume":"51","author":"Fullmer, C.S.; Rosen, J.F.","year":"1990","unstructured":"Fullmer CS, Rosen JF. EVect of dietary calcium and lead status on intestinal calcium absorption. Environ Res 1990;51:91\u20139.","journal-title":"Environ Res"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0041-008X(90)90246-Q","article-title":"Lead impairs the production of osteocalcin by rat osteosarcoma (ROS 17\/2.8) cells","volume":"106","author":"Long, G.J.; Rosen, J.F.; Pounds, J.G.","year":"1990","unstructured":"Long GJ, Rosen JF, Pounds JG. Lead impairs the production of osteocalcin by rat osteosarcoma (ROS 17\/2.8) cells. Toxicol Appl Pharmacol 1990;106:270\u20137.","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1289\/ehp.919117","article-title":"Cellular and molecular toxicity of lead in bone","volume":"91","author":"Pounds, J.G.; Long, G.J.; Rosen, J.F.","year":"1991","unstructured":"Pounds JG, Long GJ, Rosen JF. Cellular and molecular toxicity of lead in bone, [review]. Environ Health Perspect 1991; 91:17\u201332.","journal-title":"Environ Health Perspect"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1016\/S0021-9258(18)88853-6","article-title":"Lead-binding properties of intestinal calcium-binding proteins","volume":"260","author":"Fullmer, C.S.; Edelstein, S.; Wasserman, R.H.","year":"1985","unstructured":"Fullmer CS, Edelstein S, Wasserman RH. Lead-binding properties of intestinal calcium-binding proteins. J Biol Chem 1985;260:6816\u20139.","journal-title":"J Biol Chem"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1056\/NEJM198005153022006","article-title":"Reduction in 1,25-dihydroxyvitamin D in children with increased lead absorption","volume":"302","author":"Rosen, J.F.; Chesney, R.W.; Hamstra, A.","year":"1980","unstructured":"Rosen JF, Chesney RW, Hamstra A, et al. Reduction in 1,25-dihydroxyvitamin D in children with increased lead absorption. N Engl J Med 1980;302:1128\u201331.","journal-title":"N Engl J Med"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/00039896.1975.10666776","article-title":"Bone and kidney lesions in experimental cadmium intoxication","volume":"30","author":"Yoshiki, S.; Yanagisawa, T.; Kimura, M.","year":"1975","unstructured":"Yoshiki S, Yanagisawa T, Kimura M, et al. Bone and kidney lesions in experimental cadmium intoxication. Arch Environ Health 1975;30:559\u201362.","journal-title":"Arch Environ Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1289\/ehp.8454193","article-title":"Renal function in relation to low levels of cadmium exposure in a group of smelter workers","volume":"54","author":"Kazantzis, G.; Armstrong, B.G.","year":"1984","unstructured":"Kazantzis G, Armstrong BG. Renal function in relation to low levels of cadmium exposure in a group of smelter workers. Environ Health Perspect 1984;54:193\u20139.","journal-title":"Environ Health Perspect"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"220","DOI":"10.5271\/sjweh.1929","article-title":"Mortality of cadmiumexposed workers. A five-year update","volume":"14","author":"Kazantzis, G.; Lam, T.H.; Sullivan, K.R.","year":"1988","unstructured":"Kazantzis G, Lam TH, Sullivan KR. Mortality of cadmiumexposed workers. A five-year update. Scand J Work Environ Health 1988;14:220\u20133.","journal-title":"Scand J Work Environ Health"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/BF00308324","article-title":"Decrease in bone levels of 1,25-dihydroxyvitamin D in women with subcapital fracture of the femur","volume":"52","author":"Lidor, C.; Sagiv, P.; Amdur, B.","year":"1993","unstructured":"Lidor C, Sagiv P, Amdur B, et al. Decrease in bone levels of 1,25-dihydroxyvitamin D in women with subcapital fracture of the femur. Calcif Tissue Int 1993;52: 146\u20138.","journal-title":"Calcif Tissue Int"},{"key":"ref_33","first-page":"231","article-title":"Competitive protein-binding assay for 25-hydroxycholecalciferol","volume":"46","author":"Edelstein, S.; Charman, M.; Lawson, D.E.","year":"1974","unstructured":"Edelstein S, Charman M, Lawson DE, et al. Competitive protein-binding assay for 25-hydroxycholecalciferol. Clin Sci Mol Med 1974;46:231\u201340.","journal-title":"Clin Sci Mol Med"},{"issue":"77","key":"ref_34","first-page":"40","article-title":"An improvement of the Coomassie blue dye binding method allowing an equal sensitivity to various proteins: application to cerebrospinal fluid. Clin Chim Acta 1982; 122: 93 39 Macart M, Gerbaut L. Evaluation of an improved Coomassie blue dye binding method for urinary protein assay","volume":"141","author":"Macart, M.; Gerbaut, L.","year":"1984","unstructured":"Macart M, Gerbaut L. An improvement of the Coomassie blue dye binding method allowing an equal sensitivity to various proteins: application to cerebrospinal fluid. Clin Chim Acta 1982;122:93 39 Macart M, Gerbaut L. Evaluation of an improved Coomassie blue dye binding method for urinary protein assay. Clin Chim Acta 1984;141:77 40 Rosen JF, Chesney RW. Medical progress: circulating calcitriol concentrations in health and disease. J Pediatr 1983;103:1\u201317.","journal-title":"Clin Chim Acta; Medical progress: circulating calcitriol concentrations in health and disease"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1001\/jama.1994.03520040039038","article-title":"Blood lead levels in the US population. Phase I of the third National Health and Nutrition Examination Study (NHANES III 1988 to","volume":"272","author":"Brody, D.J.; Pirkle, J.L.; Kramer, R.A.","year":"1991","unstructured":"Brody DJ, Pirkle JL, Kramer RA, et al. Blood lead levels in the US population. Phase I of the third National Health and Nutrition Examination Study (NHANES III 1988 to 1991). JAMA 1994;272:277\u201383.","journal-title":"JAMA"},{"key":"ref_36","first-page":"195","article-title":"Health eVects of environmental exposure to cadmium in a population study","volume":"7","author":"Staessen, J.; Lauwerys, R.","year":"1993","unstructured":"Staessen J, Lauwerys R. Health eVects of environmental exposure to cadmium in a population study. J Hum Hypertens 1993;7:195\u20139.","journal-title":"J Hum Hypertens"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/ajcn\/35.6.1327","article-title":"Association between age, blood lead concentration, and serum 1,25-dihydroxycholecalciferol levels in children","volume":"35","author":"MahaVey, K.R.; Rosen, J.F.; Chesney, R.W.","year":"1982","unstructured":"MahaVey KR, Rosen JF, Chesney RW, et al. Association between age, blood lead concentration, and serum 1,25-dihydroxycholecalciferol levels in children. Am J Clin Nutr 1982;35:1327\u201331.","journal-title":"Am J Clin Nutr"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/jbmr.5650050902","article-title":"The renal mitochondrial hydroxylases of the vitamin D3 endocrine complex: how are they regulated at the molecular level?","volume":"5","author":"Ghazarian, J.G.","year":"1990","unstructured":"Ghazarian JG. The renal mitochondrial hydroxylases of the vitamin D3 endocrine complex: how are they regulated at the molecular level? [review]. J Bone Miner Res 1990;5: 897\u2013903.","journal-title":"J Bone Miner Res"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/BF00296777","article-title":"Lead intoxication alters basal and parathyroid hormone-regulated cellular calcium homeostasis in rat osteosarcoma (ROS 17\/2.8) cells","volume":"50","author":"Long, G.J.; Pounds, J.G.; Rosen, J.F.","year":"1992","unstructured":"Long GJ, Pounds JG, Rosen JF. Lead intoxication alters basal and parathyroid hormone-regulated cellular calcium homeostasis in rat osteosarcoma (ROS 17\/2.8) cells. Calcif Tissue Int 1992;50:451\u20138.","journal-title":"Calcif Tissue Int"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/taap.1994.1090","article-title":"Cadmiuminduced osteomalacic and osteopetrotic lesions in ovariectomized rats","volume":"126","author":"Katsuta, O.; Hiratsuka, H.; Matsumoto, J.","year":"1994","unstructured":"Katsuta O, Hiratsuka H, Matsumoto J, et al. Cadmiuminduced osteomalacic and osteopetrotic lesions in ovariectomized rats. Toxicol Appl Pharmacol 1994;126:58\u201368.","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/15287399509531994","article-title":"EVect of cadmium on bone repair in young rats","volume":"45","author":"Gur, E.; Waner, T.; Barushka Eizik, O.","year":"1995","unstructured":"Gur E, Waner T, Barushka Eizik O, et al. EVect of cadmium on bone repair in young rats. J Toxicol Environ Health 1995; 45:249\u201360.","journal-title":"J Toxicol Environ Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0300-483X(92)90097-X","article-title":"Lead nephrotoxicity and associated disorders: biochemical mechanisms","volume":"73","author":"Nolan, C.V.; Shaikh, Z.A.","year":"1992","unstructured":"Nolan CV, Shaikh ZA. Lead nephrotoxicity and associated disorders: biochemical mechanisms, [review]. Toxicology 1992;73:127\u201346.","journal-title":"Toxicology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/path.1711120404","article-title":"Intracellular inclusions in the lead-poisoned cultured kidney cell","volume":"112","author":"Walton, JR","year":"1974","unstructured":"Walton JR. Intracellular inclusions in the lead-poisoned cultured kidney cell. J Pathol 1974;112:213.","journal-title":"J Pathol"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1289\/ehp.9089101","article-title":"Transplacental transport of lead","volume":"89","author":"Goyer, R.A.","year":"1990","unstructured":"Goyer RA. Transplacental transport of lead, [review]. Environ Health Perspect 1990;89:101\u20135.","journal-title":"Environ Health Perspect"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/10408449009089864","article-title":"Neuropsychological eVect of lead in occupationally exposed workers: a critical review","volume":"20","author":"Ehle, A.L.; McKee, D.C.","year":"1990","unstructured":"Ehle AL, McKee DC. Neuropsychological eVect of lead in occupationally exposed workers: a critical review. Crit Rev Toxicol 1990;20:237\u201355.","journal-title":"Crit Rev Toxicol"},{"key":"ref_46","first-page":"290","article-title":"Calcium and vitamin D homeostasis in patients with heavy proteinuria","volume":"41","author":"Saha, H.H.","year":"1994","unstructured":"Saha HH. Calcium and vitamin D homeostasis in patients with heavy proteinuria. Clin Nephrol 1994;41:290\u20136.","journal-title":"Clin Nephrol"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0009-8981(92)90189-W","article-title":"Bone metal content in patients with chronic renal failure","volume":"211","author":"Navarro, J.A.; Granadillo, V.A.; Salgado, O.","year":"1992","unstructured":"Navarro JA, Granadillo VA, Salgado O, et al. Bone metal content in patients with chronic renal failure. Clin Chim Acta 1992;211:133\u201342.","journal-title":"Clin Chim Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF00379430","article-title":"Serum vitamin D metabolites in cadmium-exposed persons with renal damage","volume":"62","author":"Nogawa, K.; Tsuritani, I.; Kido, T.","year":"1990","unstructured":"Nogawa K, Tsuritani I, Kido T, et al. Serum vitamin D metabolites in cadmium-exposed persons with renal damage. 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