{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:11:59Z","timestamp":1788304319055,"version":"build-2803163510"},"reference-count":7,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p>Sulphuric acid vapour has been suspected of being an industrial carcinogen. In this study, a cluster is presented of three patients with nasopharyngeal carcinoma (NPC) who worked in the same building of a telecommunications conveyance station in southern Taiwan with long term exposure to sulphuric acid vapour concentrations as high as 0.18 mg\/m3. All three workers were diagnosed with NPC within a 5 month period between September 1992, and March 1993. Compared with 19 other healthy workers from the same building, these three workers with NPC had worked significantly longer in this building than had the others (mean (SD) (years): 12.7 (0.6) v 7.4 (4.4); p = 0.01). With an in situ nucleic acid hybridisation and immunostaining method for colocalised Epstein-Barr virus (EBV) and secretory component (SC) protein among biopsy specimens of these three patients with NPCs, it was found that some tumour cells did not contain EBV and SC protein staining signals. These results indicate that EBV infection is not the only risk factor for NPC and long term exposure to relatively low concentrations of sulphuric acid vapour may be associated with the development of NPC.<\/jats:p>","DOI":"10.1136\/oem.56.6.426","type":"journal-article","created":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:13:30Z","timestamp":1230768810000},"page":"426-428","source":"Crossref","is-referenced-by-count":24,"title":["Suspected nasopharyngeal carcinoma in three workers with long-term exposure to sulphuric acid vapour."],"prefix":"10.1136","volume":"56","author":[{"given":"C K","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W C","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D C","family":"Christiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C T","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,6,1]]},"reference":[{"key":"ref_1","article-title":"International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans. Vol 54. Occupational exposures to mists and vapors from strong inorganic acid and other industrial chemicals","year":"1992","unstructured":"International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans. Vol 54. Occupational exposures to mists and vapors from strong inorganic acid and other industrial chemicals. Lyon: IARC, 1992."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1136\/oem.53.7.445","article-title":"Upper aerodigestive cancer in battery manufacturers and steel workers exposed to mineral acid mists","volume":"53","author":"Coggon, D.; Pannett, B.; Wield, G.","year":"1996","unstructured":"Coggon D, Pannett B, Wield G. Upper aerodigestive cancer in battery manufacturers and steel workers exposed to mineral acid mists. 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Epidemiol Rev 1993;15:466\u201385.","journal-title":"Epidemiol Rev"},{"key":"ref_7","first-page":"793","article-title":"Clonal versus polygonal Epstein-Barr virus infection in nasopharyngeal carcinoma cell lines","volume":"76","author":"Lin, C.T.; Chan, W.S.; Hsu, M.M.","year":"1997","unstructured":"Lin CT, Chan WS, Hsu MM, et al. Clonal versus polygonal Epstein-Barr virus infection in nasopharyngeal carcinoma cell lines. Lab Invest 1997;76:793\u20138.","journal-title":"Lab Invest"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oem.56.6.426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T17:14:36Z","timestamp":1716484476000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oem.56.6.426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":7,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1999,6,1]]},"published-print":{"date-parts":[[1999,6]]}},"alternative-id":["10.1136\/oem.56.6.426"],"URL":"https:\/\/doi.org\/10.1136\/oem.56.6.426","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}