{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:12:47Z","timestamp":1782515567152,"version":"3.54.5"},"reference-count":12,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"OBJECTIVE<\/jats:title>To give the observed and expected deaths due to cancer at all separate sites in asbestos workers in east London, and to analyse these for overall effect and exposure-response trend.<\/jats:p><\/jats:sec>METHODS<\/jats:title>The mortality experience of a cohort of over 5000 men and women followed up for over 30 years since first exposure to asbestos has been extracted.<\/jats:p><\/jats:sec>RESULTS<\/jats:title>There was a large excess of deaths due to cancer (537 observed, 222 expected). Most of these were due to cancer of the lung (232 observed, 77 expected) and pleural (52) and peritoneal (48) mesothelioma. The exposure-response trend for all these three causes was highly significant. There was also an excess of cancer of the colon (27 observed, 15 expected) which was significantly related to exposure. There were significant excesses of cancer of the ovary, of the liver, and of the oesophagus but with no consistent relation to exposure.<\/jats:p><\/jats:sec>CONCLUSIONS<\/jats:title>The excess risk of cancer after exposure to asbestos was mainly due to cancer of the lung and mesothelioma. An exposure related excess of cancer of the colon was also detected but the possibility that some of these deaths may have been peritoneal mesotheliomas could not be excluded. There was no consistent evidence of exposure related excesses at any other site.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oem.57.11.782","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:38:40Z","timestamp":1027766320000},"page":"782-785","source":"Crossref","is-referenced-by-count":74,"title":["Mortality from all cancers of asbestos factory workers in east London 1933\u201380"],"prefix":"10.1136","volume":"57","author":[{"given":"G","family":"Berry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Newhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"2024052310252968000_57.11.782.1","first-page":"294","article-title":"A study of the mortality of workers in an asbestos factory.","volume":"26","author":"Newhouse","year":"1969","journal-title":"Br J Ind Med"},{"key":"2024052310252968000_57.11.782.2","first-page":"302","article-title":"Validation of death certificates in asbestos workers.","volume":"26","author":"Newhouse","year":"1969","journal-title":"Br J Ind Med"},{"key":"2024052310252968000_57.11.782.3","first-page":"134","article-title":"A study of the mortality of female asbestos workers.","volume":"29","author":"Newhouse","year":"1972","journal-title":"Br J Ind Med"},{"key":"2024052310252968000_57.11.782.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)90126-2"},{"key":"2024052310252968000_57.11.782.5","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0140-6736(73)92438-0","article-title":"Asbestos and laryngeal carcinoma [letter].","volume":"ii","author":"Newhouse","year":"1973","journal-title":"Lancet"},{"key":"2024052310252968000_57.11.782.6","first-page":"147","article-title":"Predictions of mortality from mesothelial tumours in asbestos factory workers.","volume":"33","author":"Newhouse","year":"1976","journal-title":"Br J Ind Med"},{"key":"2024052310252968000_57.11.782.7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1749-6632.1979.tb18709.x","article-title":"Patterns of mortality in asbestos factory workers in London.","volume":"330","author":"Newhouse","year":"1979","journal-title":"Ann NY Acad Sci"},{"key":"2024052310252968000_57.11.782.8","first-page":"4","article-title":"Mortality of factory workers in east London 1933\u00e2\u0080\u009380.","volume":"42","author":"Newhouse","year":"1985","journal-title":"Br J Ind Med"},{"key":"2024052310252968000_57.11.782.9","first-page":"12","article-title":"Combined effect of asbestos and smoking on mortality from lung cancer and mesothelioma in factory workers.","volume":"42","author":"Berry","year":"1985","journal-title":"Br J Ind Med"},{"key":"2024052310252968000_57.11.782.10","unstructured":"Armitage P Berry G (1994) Statistical methods in medical research (Blackwell, Oxford), 3rd ed. p 410."},{"key":"2024052310252968000_57.11.782.11","unstructured":"Cytel Software Corporation (1991) StatXact: statistical software for exact non-parametric inference, user manual version 2. 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