{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:40:51Z","timestamp":1777110051005,"version":"3.51.4"},"reference-count":34,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>In response to a previous finding of increased mortality from lymphohaematopoietic (LH) malignancies, this study examines incidence of LH malignancy in a petrochemical industry cohort. Emphasis is on chronic lymphocytic leukaemia (CLL) and on comparisons by period of first employment.<\/jats:p><\/jats:sec><jats:sec sec-type=\"methods\"><jats:title>METHOD<\/jats:title><jats:p>The study cohort consists of 8942 employees who were active in the period 1970\u201392 and alive on 31 December 1982. Record linkage with the Louisiana tumour registry (LTR) provided information on cancer for cases occurring between 1983 and 1994. Standardised incidence ratios (SIR), with the south Louisiana population as a comparison, were computed for all cancers, all LH malignancies and specific LH subtypes. Analyses were conducted for sex and race categories, and by period of first employment, job type, duration of employment, and latency.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>672 Cases of cancer were identified, including 59 LH malignancies. Women (n=1169) had an overall cancer SIR below unity and four LH malignancies versus 2.28 expected. Among the 7773 men, those first employed before 1950 had no overall cancer excess, a significant 1.4-fold increase in overall LH malignancies (43 observed versus 30.78 expected), and four CLL cases versus 3.27 expected. Findings for men first employed after 1950 are based on fewer cases, but there was no indication of excesses of overall cancer or LH malignancy. Numbers were too small in the group first employed after 1950 for meaningful analysis of LH malignancy subtypes such as CLL (one case).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>These findings do not suggest a continuing excess of CLL but do suggest a small increase in incidence of overall LH malignancy for workers first employed before 1950. This may reflect associations with earlier workplace conditions, although work related patterns are mixed. Interpretation is limited by the diverse group of diseases within LH malignancies, and the lack of control for non-work factors other than sex, age, race, and period of diagnosis. This study has a major advantage of more complete and reliable cancer ascertainment compared with the mortality investigation, and shows the feasibility and benefits of using cancer registry incidence data in an occupational cohort study.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oem.57.9.605","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:38:40Z","timestamp":1027766320000},"page":"605-614","source":"Crossref","is-referenced-by-count":25,"title":["Incidence of lymphohaematopoietic malignancies in a petrochemical industry cohort: 1983\u201394 follow up"],"prefix":"10.1136","volume":"57","author":[{"given":"Wendy W","family":"Huebner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivien W","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry R","family":"Friedlander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao C","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiyaz A","family":"Bhojani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig H","family":"Friedmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth A","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene A","family":"Sales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javed A","family":"Joy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine N","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2024052310403628000_57.9.605.1","unstructured":"Lewis RJ, Gamble JF, Jorgensen G. Mortality among three refinery\/petrochemical plant cohorts. I. 1970\u00e2\u0080\u009382 Active\/terminated workers. J Occup Environ Med (in press).."},{"key":"2024052310403628000_57.9.605.2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00043764-198505000-00016","article-title":"A retrospective mortality study of workers in three major US refineries and chemical plants. Part 1: Comparisons with US population.","volume":"27","author":"Hanis","year":"1985","journal-title":"J Occup Med"},{"key":"2024052310403628000_57.9.605.3","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-198505000-00016"},{"key":"2024052310403628000_57.9.605.4","first-page":"345","article-title":"An updated mortality study of workers in three major United States refineries and chemical plants.","volume":"49","author":"Shallenberger","year":"1992","journal-title":"Br J Ind Med"},{"key":"2024052310403628000_57.9.605.5","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199710000-00009"},{"key":"2024052310403628000_57.9.605.6","first-page":"1211","article-title":"Guidelines for good epidemiology practices for occupational and environmental epidemiologic research. Epidemiology Resource and Information Center (ERIC) Pilot Project.","volume":"33","year":"1991","journal-title":"J Occup Med"},{"key":"2024052310403628000_57.9.605.7","unstructured":"Chen VW Correa CN Wu XC (1996) Cancer Incidence in Louisiana, 1988\u00e2\u0080\u009392. (Louisiana Tumor Registry, New Orleans) . (Cancer in Louisiana 1996;8:1).."},{"key":"2024052310403628000_57.9.605.8","unstructured":"Chen VW Wu XC Andrews PA , eds (1998) Cancer incidence in North America, 1990\u00e2\u0080\u009394. Vol 1. Incidence. (North American Association of Central Cancer Registries, Sacramento, CA)."},{"key":"2024052310403628000_57.9.605.9","unstructured":"Parkin DM Muir CS Whelan SI , eds (1992) Cancer incidence in five continents. Vol 6. (International Agency for Research on Cancer, Lyon, France) . (IARC Sci Publ No 120.)."},{"key":"2024052310403628000_57.9.605.10","doi-asserted-by":"publisher","DOI":"10.2307\/2684074"},{"key":"2024052310403628000_57.9.605.11","first-page":"947","article-title":"Lung cancer mortality as related to residence and smoking histories.","volume":"28","author":"Haenszel","year":"1962","journal-title":"J Natl Cancer Inst"},{"key":"2024052310403628000_57.9.605.12","unstructured":"World Health Organisation (1976) International classification of diseases for oncology. (WHO, Geneva, Switzerland)."},{"key":"2024052310403628000_57.9.605.13","unstructured":"Percy C Van Holten V Muir C (1990) International classification of diseases for oncology, 2d ed. (World Health Organisation, Geneva, Switzerland)."},{"key":"2024052310403628000_57.9.605.14","unstructured":"World Health Organisation (1977) Ninth revision of the international statistical classification of diseases, injuries, and causes of death, 1977 ed. (WHO, Geneva), 1."},{"key":"2024052310403628000_57.9.605.15","unstructured":"(1992) SEER program code manual, appendix b. Revised June, 1992. Surveillance, epidemiology and end results, (SEER). (National Cancer Institute, Bethesda, MD)."},{"key":"2024052310403628000_57.9.605.16","first-page":"511","article-title":"A prospective study in the Australian petroleum industry. II. Incidence of cancer.","volume":"48","author":"Christie","year":"1991","journal-title":"Br J Ind Med"},{"key":"2024052310403628000_57.9.605.17","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199808000-00003"},{"key":"2024052310403628000_57.9.605.18","first-page":"455","article-title":"Epidemiologic studies of the petroleum industry.","volume":"3","author":"Delzell","year":"1988","journal-title":"Journal of Occupational Medicine: State of the Art Reviews"},{"key":"2024052310403628000_57.9.605.19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ajim.4700150305","article-title":"Critical review of cancer epidemiology in petroleum industry employees, with a quantitative meta-analysis by cancer site.","volume":"15","author":"Wong","year":"1989","journal-title":"Am J Ind Med"},{"key":"2024052310403628000_57.9.605.20","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-198110000-00012"},{"key":"2024052310403628000_57.9.605.21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/oxfordjournals.aje.a009127","article-title":"Risk of cancer and exposure to gasoline vapors.","volume":"145","author":"Lynge","year":"1997","journal-title":"Am J Epidemiol"},{"key":"2024052310403628000_57.9.605.22","first-page":"171","article-title":"Long-term mortality study of oil refinery workers: V. Comparison of workers hired before, during, and after World War II (1940\u00e2\u0080\u00935) with a discussion of the impact of study designs on cohort results.","volume":"9","author":"Wen","year":"1986","journal-title":"Am J Occup Med"},{"key":"2024052310403628000_57.9.605.23","doi-asserted-by":"crossref","first-page":"250","DOI":"10.5271\/sjweh.2469","article-title":"Environmental epidemiologic investigation of the styrene-butadiene rubber industry.","volume":"8","author":"Meinhardt","year":"1982","journal-title":"Scand J Work Environ Health"},{"key":"2024052310403628000_57.9.605.24","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1995.1044"},{"key":"2024052310403628000_57.9.605.25","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199605000-00010"},{"key":"2024052310403628000_57.9.605.26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/oem.56.3.174","article-title":"Update of the Texaco mortality study of 1947\u00e2\u0080\u009393: Part II. Analyses of specific causes of death for white men employed in refining, research, and petrochemicals.","volume":"56","author":"Divine","year":"1999","journal-title":"Occup Environ Med"},{"key":"2024052310403628000_57.9.605.27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ajim.4700050307","article-title":"An evaluation of the associations of leukemia and rubber industry solvent exposures.","volume":"5","author":"Checkoway","year":"1984","journal-title":"Am J Ind Med"},{"key":"2024052310403628000_57.9.605.28","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/oxfordjournals.aje.a115442","article-title":"Chronic lymphocytic leukemia in relation to chemical exposures.","volume":"130","author":"Malone","year":"1989","journal-title":"Am J Epidemiol"},{"key":"2024052310403628000_57.9.605.29","first-page":"136","article-title":"Comparison of methods for determining occupational exposure in a case-control interview study of chronic lymphocytic leukemia.","volume":"29","author":"Linet","year":"1987","journal-title":"J Occup Med"},{"key":"2024052310403628000_57.9.605.30","doi-asserted-by":"publisher","DOI":"10.1136\/oem.54.3.152"},{"key":"2024052310403628000_57.9.605.31","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199511000-00005"},{"key":"2024052310403628000_57.9.605.32","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.14.1065"},{"key":"2024052310403628000_57.9.605.33","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199701)31:1<21::AID-AJIM4>3.0.CO;2-#"},{"key":"2024052310403628000_57.9.605.34","unstructured":"Ries LAG Kosary CL Hankey BF , eds (1998) SEER cancer statistics review, 1973\u00e2\u0080\u009395. (National Cancer Institute, Bethesda, MD)."}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oem.57.9.605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T18:43:42Z","timestamp":1716489822000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oem.57.9.605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,1]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2000,9,1]]},"published-print":{"date-parts":[[2000,9,1]]}},"alternative-id":["10.1136\/oem.57.9.605"],"URL":"https:\/\/doi.org\/10.1136\/oem.57.9.605","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,1]]}}}