{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:04:50Z","timestamp":1759730690571},"reference-count":12,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>About 25% of greenhouse flower and\/or ornamental plant growers sensitised to workplace flowers or moulds have occupational asthma, a disease that is suffered by 8% of the growers who cultivate these crops.<\/jats:p><jats:p><jats:bold>Aim:<\/jats:bold>To document a case of occupational asthma due to IgE mediated allergy to the flower<jats:italic>Molucella laevis<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Methods and Results:<\/jats:bold>There was a history of work related seasonal asthmatic and rhinoconjunctivitis symptoms in a<jats:italic>Molucella laevis<\/jats:italic>grower. Bronchial obstruction following exposure to<jats:italic>Molucella laevis<\/jats:italic>was documented by a fall in FEV<jats:sub>1<\/jats:sub>from 89% to 73% of predicted during seasonal exposure to<jats:italic>Molucella laevis.<\/jats:italic>Daily PEF measurements showed a fall from 500 to 250 l\/min during this period following withdrawal of inhaled steroids. Bronchial reactivity to inhaled methacholine was increased (PC<jats:sub>20<\/jats:sub>1.45 mg\/ml). Confirmation of sensitisation to<jats:italic>Molucella laevis<\/jats:italic>flower pollen extract was done using an SPT and by demonstration of<jats:italic>Molucella laevis<\/jats:italic>specific serum IgE (18 IU\/ml; class 4). Specific inhalation challenge with<jats:italic>Molucella laevis<\/jats:italic>extract provoked an early and late asthmatic reaction (EAR and LAR) with a fall in FEV<jats:sub>1<\/jats:sub>compared with control day of 40% and 53% respectively, with associated 5.1-fold increase in absolute sputum eosinophil cell counts and 2.9-fold increase in neutrophil cell counts.<\/jats:p>","DOI":"10.1136\/oem.60.9.701","type":"journal-article","created":{"date-parts":[[2003,8,22]],"date-time":"2003-08-22T19:02:15Z","timestamp":1061578935000},"page":"701-703","source":"Crossref","is-referenced-by-count":11,"title":["Occupational asthma due to IgE mediated allergy to the flower<i>Molucella laevis<\/i>(Bells of Ireland): Figure 1"],"prefix":"10.1136","volume":"60","author":[{"given":"W M A J","family":"Miesen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"van der Heide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H A M","family":"Kerstjens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A E J","family":"Dubois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G R","family":"de Monchy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2003,8,22]]},"reference":[{"key":"2024052910282896000_60.9.701.1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2000.0783"},{"key":"2024052910282896000_60.9.701.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202-098OC"},{"key":"2024052910282896000_60.9.701.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012670"},{"key":"2024052910282896000_60.9.701.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1977.tb01448.x"},{"key":"2024052910282896000_60.9.701.5","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1997.0492"},{"key":"2024052910282896000_60.9.701.6","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1164\/ajrccm.163.7.2010145","volume":"163","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2024052910282896000_60.9.701.7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00383369"},{"key":"2024052910282896000_60.9.701.8","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00947.x"},{"key":"2024052910282896000_60.9.701.9","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63042-6"},{"key":"2024052910282896000_60.9.701.10","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90015-6"},{"key":"2024052910282896000_60.9.701.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70132-6"},{"key":"2024052910282896000_60.9.701.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70444-6"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oem.60.9.701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T17:29:53Z","timestamp":1717003793000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oem.60.9.701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,22]]},"references-count":12,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2003,8,22]]},"published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1136\/oem.60.9.701"],"URL":"https:\/\/doi.org\/10.1136\/oem.60.9.701","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,22]]}}}