{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:50:34Z","timestamp":1789631434924,"version":"build-2803163510"},"reference-count":36,"publisher":"BMJ","issue":"6","funder":[{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004851","name":"New York City Department of Health and Mental Hygiene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005220","name":"Agency for Toxic Substances and Disease Registry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2017,2,15]]},"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We studied the course of lower respiratory symptoms (LRS; cough, wheeze or dyspnoea) among community members exposed to the 9\/11\/2001 World Trade Center (WTC) attacks during a period of 12\u201313 years following the attacks, and evaluated risk factors for LRS persistence, including peripheral airway dysfunction and post-traumatic stress disorder (PTSD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Non-smoking adult participants in a case-control study of post-9\/11-onset LRS (exam 1, 2008\u20132010) were recruited for follow-up (exam 2, 2013\u20132014). Peripheral airway function was assessed with impulse oscillometry measures of R<jats:sub>5<\/jats:sub> and R<jats:sub>5-20<\/jats:sub>. Probable PTSD was a PTSD checklist score <jats:underline>\u2265<\/jats:underline>44 on a 2006\u20132007 questionnaire.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 785 exam 1 participants, 545 (69%) completed exam 2. Most (321, 59%) were asymptomatic at all assessments. Among 192 participants with initial LRS, symptoms resolved for 110 (57%) by exam 2, 55 (29%) had persistent LRS and 27 (14%) had other patterns. The proportion with normal spirometry increased from 65% at exam 1 to 85% at exam 2 in the persistent LRS group (p&lt;0.01) and was stable among asymptomatic participants and those with resolved LRS. By exam 2, spirometry results did not differ across symptom groups; however, R<jats:sub>5<\/jats:sub> and R<jats:sub>5-20<\/jats:sub> abnormalities were more common among participants with persistent LRS (56% and 46%, respectively) than among participants with resolved LRS (30%, p&lt;0.01; 27%, p=0.03) or asymptomatic participants (20%, p&lt;0.001; 8.2%, p&lt;0.001). PTSD, R<jats:sub>5<\/jats:sub> at exam 1, and R<jats:sub>5-20<\/jats:sub> at exam 1 were each independently associated with persistent LRS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Peripheral airway dysfunction and PTSD may contribute to LRS persistence. Assessment of peripheral airway function detected pulmonary damage not evident on spirometry. Mental and physical healthcare for survivors of complex environmental disasters should be coordinated carefully.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/oemed-2016-104157","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T01:23:58Z","timestamp":1490405038000},"page":"449-455","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Risk factors for persistence of lower respiratory symptoms among community members exposed to the 2001 World Trade Center terrorist attacks"],"prefix":"10.1136","volume":"74","author":[{"given":"Hannah T","family":"Jordan","sequence":"first","affiliation":[{"name":"World Trade Center Health Registry, New York City Department of Health and Mental Hygiene, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Friedman","sequence":"additional","affiliation":[{"name":"World Trade Center Health 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