{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:18:56Z","timestamp":1758961136140,"version":"3.37.3"},"reference-count":12,"publisher":"BMJ","issue":"6","funder":[{"name":"Danish Working Environment Research Fund"},{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal adenocarcinoma is a rare disease expected to have rare causes and potential for strong risk factors as reflected by the strong association with occupational wood dust exposure. High level styrene exposure is a rare and suspected carcinogen, and this study examines the exposure\u2013response relation between occupational styrene exposure, sinonasal adenocarcinoma and other subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed 73\u2009092 styrene-exposed workers from 1968 to 2011 and identified sinonasal cancers in the Danish Cancer Registry. We modelled cumulative styrene exposure and estimated incidence rates and age, sex and wood-industry adjusted ORs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 1 585 772 person-years, we observed nine cases of adenocarcinoma, corresponding to a fivefold non-significantly increased OR for estimates of high versus low cumulative styrene exposure (OR 5.11, 95% CI 0.58 to 45.12). The increased risk was confined to exposure received during the recent 15 years. The other histological subtypes showed no increased risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests increased risk of sinonasal adenocarcinoma following styrene exposure. The observations are, however, few, confounding from wood dust exposure cannot be ruled out, and additional studies are needed before firm conclusions can be drawn.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2017-104974","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T16:21:25Z","timestamp":1521044485000},"page":"412-414","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Sinonasal adenocarcinoma following styrene exposure in the reinforced plastics industry"],"prefix":"10.1136","volume":"75","author":[{"given":"Mette Schou","family":"Nissen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zara Ann","family":"Stokholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette Skovgaard","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivi","family":"Schl\u00fcnssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper Medom","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge Brosb\u00f8l","family":"Iversen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6535-4323","authenticated-orcid":false,"given":"Henrik Albert","family":"Kolstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"2020050723010140000_75.6.412.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5605.587"},{"key":"2020050723010140000_75.6.412.2","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700280202"},{"issue":"Pt C","key":"2020050723010140000_75.6.412.3","first-page":"11","article-title":"Arsenic, metals, fibres, and dusts","volume":"100","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"2020050723010140000_75.6.412.4","first-page":"390","article-title":"A brief history of scrotal cancer","volume":"40","author":"Waldron","year":"1983","journal-title":"Br J Ind Med"},{"key":"2020050723010140000_75.6.412.5","first-page":"150","article-title":"Angiosarcoma of liver in the manufacture of polyvinyl chloride","volume":"16","author":"Creech","year":"1974","journal-title":"J Occup Med"},{"key":"2020050723010140000_75.6.412.6","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/oxfordjournals.aje.a112335","article-title":"Causes","volume":"104","author":"Rothman","year":"1976","journal-title":"Am J Epidemiol"},{"key":"2020050723010140000_75.6.412.7","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000608"},{"key":"2020050723010140000_75.6.412.8","first-page":"1","article-title":"Some traditional herbal medicines, some mycotoxins, naphthalene and styrene","volume":"82","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2002","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"2020050723010140000_75.6.412.9","unstructured":"Christensen MS , Vestergaard JM , d\u2019Amore F , et al . Styrene exposure and risk of lymphohematopoietic malignancies in 73,036 reinforced plastics workers. Epidemiology. In Press."},{"key":"2020050723010140000_75.6.412.10","unstructured":"National Academy of Sciences. Committee to review the styrene assessment in the national toxicology program 12th report on carcinogens, board on environmental studies and toxicology, division on earth and life studies, national research council. Washington (DC): National Academy of Sciences, 2014."},{"issue":"Pt F","key":"2020050723010140000_75.6.412.11","first-page":"9","article-title":"Chemical agents and related occupations","volume":"100","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"2020050723010140000_75.6.412.12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/(SICI)1097-0274(199907)36:1<101::AID-AJIM14>3.0.CO;2-A","article-title":"Sinonasal cancer, occupation, and tobacco smoking in European women and men","volume":"36","author":"\u2019t Mannetje","year":"1999","journal-title":"Am J Ind Med"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oemed-2017-104974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T07:41:00Z","timestamp":1601106060000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oemed-2017-104974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,14]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,5,17]]},"published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1136\/oemed-2017-104974"],"URL":"https:\/\/doi.org\/10.1136\/oemed-2017-104974","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"type":"print","value":"1351-0711"},{"type":"electronic","value":"1470-7926"}],"subject":[],"published":{"date-parts":[[2018,3,14]]}}}