{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:57:44Z","timestamp":1790621864426,"version":"4.1.0"},"reference-count":37,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the association between occupational polycyclic aromatic hydrocarbon (PAH) exposure and female breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lifetime work histories for 1130 cases and 1169 controls from British Columbia and Ontario (Canada) were assessed for PAH exposure using a job-exposure matrix based on compliance measurements obtained during US Occupational Safety and Health Administration workplace safety inspections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exposure to any level of PAHs was associated with an increased risk of breast cancer (OR=1.32, 95%\u2009CI: 1.10 to 1.59), as was duration at high PAH exposure (for &gt;7.4 years: OR=1.45, 95%\u2009CI: 1.10 to 1.91; p<jats:sub>trend<\/jats:sub>=0.01), compared with women who were never exposed. Increased risk of breast cancer was most strongly associated with prolonged duration at high occupational PAH exposure among women with a family history of breast cancer (for &gt;7.4 years: OR=2.79, 95%\u2009CI: 1.25 to 6.24; p<jats:sub>trend<\/jats:sub>&lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that prolonged occupational exposure to PAH may increase breast cancer risk, especially among women with a family history of breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2018-105261","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T18:15:19Z","timestamp":1544638519000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Women\u2019s occupational exposure to polycyclic aromatic hydrocarbons and risk of breast cancer"],"prefix":"10.1136","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0079-8385","authenticated-orcid":false,"given":"Derrick G","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-4478","authenticated-orcid":false,"given":"Igor","family":"Burstyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes S","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Grundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa C","family":"Friesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristan J","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Spinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"2020050723120181000_76.1.22.1","unstructured":"IARC. 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